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2061
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2062
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2063“…Dysregulated translation of specific RNA groups could underlie feedback effects that connect and reinforce disease manifestations. …”
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2064por van Wijlick, Lasse, Geissen, René, Hilbig, Jessica S., Lagadec, Quentin, Cantero, Pilar D., Pfeifer, Eugen, Juchimiuk, Mateusz, Kluge, Sven, Wickert, Stephan, Alepuz, Paula, Ernst, Joachim F.“…In eukaryotes, Dom34 upregulates translation by securing levels of activatable ribosomal subunits. …”
Publicado 2016
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2065“…This dynamic process of migration requires the coordination of large numbers of cytosolic and transmembrane proteins whose functional activities are typically regulated by post-translational modifications (PTMs). Our recent studies have shown that the lysine methyltransferase, Ezh2, critically regulates integrin signalling and governs the adhesion dynamics of leukocytes via direct methylation of talin, a key molecule that controls these processes by linking integrins to the actin cytoskeleton. …”
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2066“…The structured process involved forward and backward translations by two independent certified translators, input from an in-country linguistic consultant, the developers, and three respiratory physicians. …”
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2067
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2068por Müller, Karolina, Edvall, Niklas K., Idrizbegovic, Esma, Huhn, Robert, Cima, Rilana, Persson, Viktor, Leineweber, Constanze, Westerlund, Hugo, Langguth, Berthold, Schlee, Winfried, Canlon, Barbara, Cederroth, Christopher R.“…In Sweden, only a few instruments are available for assessing tinnitus, and the existing tools lack validation. Therefore, we translated a set of questionnaires into Swedish and evaluated their reliability and validity in a group of tinnitus subjects. …”
Publicado 2016
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2069“…Trans-translation is a ubiquitous bacterial mechanism for ribosome rescue in the event of translation stalling. …”
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2070
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2071por Kanematsu, Akihiro“…This review provides a comprehensive view of translational research aimed at elucidating the pathophysiology of pediatric lower urinary tract dysfunction (LUTD). …”
Publicado 2016
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2072“…Moreover, accumulating reports suggest that RNA G-quadruplexes regulate translation in cap-dependent and -independent manner. …”
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2073
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2074Publicado 2017“…The BIG Data Center is dedicated to constructing and maintaining biological databases through big data integration and value-added curation, conducting basic research to translate big data into big knowledge and providing freely open access to a variety of data resources in support of worldwide research activities in both academia and industry. …”
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2075
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2076“…This review article focuses on the various aspects of translational research, where research on human subjects can ultimately enhance the diagnosis and treatment of future patients. …”
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2077“…Therefore, it is fundamental to research for computational methods aiming to help the patterns discovery for identification of the Translation Initiation Sites (TIS). In the field of Bioinformatics, machine learning methods have been widely applied based on the inductive inference, as Inductive Support Vector Machine (ISVM). …”
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2078por Hirata, Yusuke, Takahashi, Miki, Morishita, Tohru, Noguchi, Takuya, Matsuzawa, Atsushi“…Interestingly, recent evidence indicates the importance of post-translational modifications (PTMs) of TAK1 and TABs in the regulation of TAK1 activation. …”
Publicado 2017
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2079por Demuth, Hans-Ulrich, Dijkhuizen, Rick M., Farr, Tracy D., Gelderblom, Mathias, Horsburgh, Karen, Iadecola, Costantino, Mcleod, Damian D., Michalski, Dominik, Murphy, Tim H., Orbe, Josune, Otte, Willem M., Petzold, Gabor C., Plesnila, Nikolaus, Reiser, Georg, Reymann, Klaus G., Rueger, Maria A., Saur, Dorothee, Savitz, Sean I., Schilling, Stephan, Spratt, Neil J., Turner, Renée J., Vemuganti, Raghu, Vivien, Denis, Yepes, Manuel, Zille, Marietta, Boltze, Johannes“…Taken together, these current advances offer the potential to overcome almost two decades of marginally successful translational research on stroke and dementia, thereby spurring the entire field of translational neuroscience. …”
Publicado 2017
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2080por Andreev, Dmitry E., O'Connor, Patrick B. F., Loughran, Gary, Dmitriev, Sergey E., Baranov, Pavel V., Shatsky, Ivan N.“…This review will focus on how recent findings made with RiboSeq have revealed important details of the molecular mechanisms of translation in eukaryotes. These include mRNA translation sensitivity to drugs affecting translation initiation and elongation, the roles of upstream ORFs in response to stress, the dynamics of elongation and termination as well as details of intrinsic ribosome behavior on the mRNA after translation termination. …”
Publicado 2017
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