“…This work explores the solution of translating the reports to English before applying the Text Mining tools, probing the question of what translation approach should be used. …”
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“…To prevent the assembly of the MSL dosage compensation complex in female flies, Sxl acts as a repressor of male-specific lethal-2 (msl-2) mRNA translation. It uses two distinct and mutually reinforcing blocks to translation that operate on the 5′ and 3′ untranslated regions (UTRs) of msl-2 mRNA, respectively. …”
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“…Comparison of the profile of aberrant mt-tRNA (Phe) containing mitoribosomes with those of controls that integrate mt-tRNA (Val) revealed that the impaired translation seen in the latter was not due to stalling on triplets encoding either of these amino acids. …”
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“…Experimental data indicate that stochastic effects exerted at the level of translation contribute substantially to the variation in abundance of proteins expressed at moderate to high levels. …”
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“…Regulation of protein translation constitutes a crucial step in control of gene expression. …”
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“…Here we have generated a system that allows direct monitoring of mitochondrial translation in unperturbed cells. A recoded gene for superfolder GFP was inserted into the yeast (Saccharomyces cerevisiae) mitochondrial genome and enabled the detection of translation through fluorescence microscopy and flow cytometry in functional mitochondria. …”
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“…In this work, we present a review of the current landscape of existing tools designed to facilitate the visualization of multidimensional data in translational research platforms. Specifically, we reviewed the biomedical literature for translational platforms allowing the visualization and exploration of clinical and omics data, and identified 11 platforms: cBioPortal, interactive genomics patient stratification explorer, Igloo-Plot, The Georgetown Database of Cancer Plus, tranSMART, an unnamed data-cube-based model supporting heterogeneous data, Papilio, Caleydo Domino, Qlucore Omics, Oracle Health Sciences Translational Research Center and OmicsOffice(®) powered by TIBCO Spotfire. …”
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“…MOTIVATION: Translation initiation is a key step in the regulation of gene expression. …”
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“…In these studies, we have translated MICA to a pre-clinical ovine model of bone injury to evaluate functional bone repair. …”
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Materias: “…Translational Research, Design and Analysis…”
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“…The canonical molecular machinery required for global mRNA translation and its control has been well defined, with distinct sets of proteins involved in the processes of translation initiation, elongation and termination. …”
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“…Translation is a key step in the regulation of gene expression and one of the most energy-consuming processes in the cell. …”
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“…After 40 years of research, it appears more and more clearly that p53 is strongly implicated in translational regulation as well as in the control of the production and activity of the translational machinery. …”
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