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  1. 2221
    “…In 13 of 14 cases, translation of both genes is strictly coupled. Mutational analysis of SD motifs located upstream of the downstream genes indicate that the contribution of the SD to translational coupling widely varies from gene to gene. …”
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    Translational coupling via termination-reinitiation in archaea and bacteria
  2. 2222
    “…However, some CSD features do not match the clinical features of migraine headache and there are gaps in translating CSD to migraine with aura. Clinical features of migraine headache and results from research are critically evaluated; and consistent and inconsistent findings are discussed according to the known basic features of canonical CSD: typical SD limited to the cerebral cortex as it was originally defined. …”
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    Aura and Head pain: relationship and gaps in the translational models
  3. 2223
    por Seligmann, Hervé, Warthi, Ganesh
    Publicado 2019
    “…Frameshifting protein translation occasionally results from insertion of amino acids at isolated mono- or dinucleotide-expanded codons by tRNAs with expanded anticodons. …”
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    Chimeric Translation for Mitochondrial Peptides: Regular and Expanded Codons
  4. 2224
    “…Accelerating innovation translation is a priority for improving healthcare and health. …”
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    Designing for Accelerated Translation (DART) of emerging innovations in health
  5. 2225
    por O’Donnell, Marie Anne
    Publicado 2019
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    Brajendra Tripathi: Keeping an eye out for translational research
  6. 2226
    “…We provide our perspective on the who, what, where, why, and how for establishing therapeutic and translational research collaborations between academic and industry scientists.…”
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    How to develop therapeutic and translational research collaborations with industry
  7. 2227
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    MLL is required for miRNA-mediated translational repression
  8. 2228
    “…We reviewed the model with microbiome domain experts for its accuracy and completeness, and with translational researchers for its utility in different studies, and iteratively refined it. …”
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    3399 Systematically Integrating Microbiomes and Exposomes for Translational Research
  9. 2229
    “…Increasingly, project leaders (PLs) who possess this expertise are being employed in academic settings to support clinical and preclinical translational research team science. Duke University’s clinical and translational science enterprise has been an early adopter of project management to support clinical and preclinical programs. …”
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    Facilitating translational team science: The project leader model
  10. 2230
    por Kotarba, Joseph A.
    Publicado 2018
    “…OBJECTIVES/SPECIFIC AIMS: This report describes the evolution of scientific culture since the NIH/translational science (TS) mandate. The transition of the conduct of science to an increasingly translational model involves 2 dimensions of change. …”
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    2124: Three stages of cultural change in translational science
  11. 2231
    “…Our results provide evidence of translational regulation of PTBP1 protein levels during the cell cycle, which may affect downstream regulation of alternative splicing and translation mediated by PTBP1 protein isoforms.…”
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    PTBP1 mRNA isoforms and regulation of their translation
  12. 2232
    “…Peroxisomes are involved in the perception of environmental changes, which is a complex process involving the regulation of gene expression and protein functionality by protein post-translational modifications (PTMs). Although there has been a growing interest in individual PTMs in peroxisomes over the last ten years, their role and cross-talk in the whole peroxisomal proteome remain unclear. …”
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    Multilevel Regulation of Peroxisomal Proteome by Post-Translational Modifications
  13. 2233
    “…Functional decline of cardiac muscle is greatly aggravated by increased oxidative stress and damage of proteins. Oxidative post-translational modifications occur already at early stages of tissue damage and are thus regarded as potential up-coming disease markers. …”
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    Irreversible oxidative post-translational modifications in heart disease
  14. 2234
    “…Advances in fluorescence microscopy have introduced new assays to quantify live-cell translation dynamics at single-RNA resolution. We introduce a detailed, yet efficient sequence-based stochastic model that generates realistic synthetic data for several such assays, including Fluorescence Correlation Spectroscopy (FCS), ribosome Run-Off Assays (ROA) after Harringtonine application, and Fluorescence Recovery After Photobleaching (FRAP). …”
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    Computational design and interpretation of single-RNA translation experiments
  15. 2235
    “…Translational research applies scientific techniques to achieve practical outcomes, connecting pure research and pure practice. …”
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    Adapting Translational Research Methods to Water, Sanitation, and Hygiene
  16. 2236
    “…By listing necroptosis-modulated human diseases and cataloging the currently available drug-repertoire to modify necroptosis intensity, we hope to kick-start approaches with immediate translational potential. We also indicate where necroptosis regulating capacity should be considered in the current applications of these drugs.…”
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    Current translational potential and underlying molecular mechanisms of necroptosis
  17. 2237
    “…Although many hurdles remain, owing to the complexity of EV populations, translation of this “subcellular therapy” platform into reality is at hand and may soon change the landscape of the therapeutic arsenal in place to treat human degenerative and metabolic pathologies as well as diseases like cancer. …”
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    Extracellular Vesicles As Nanomedicine: Hopes And Hurdles In Clinical Translation
  18. 2238
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    DRUG REPURPOSING—Overcoming the translational hurdles to clinical use
  19. 2239
    “…The discovery of non-invasive, sensitive, and specific biomarkers is an urgent need, and translational proteomics play a key role in this process, as they enable better comprehension of colorectal carcinogenesis, identification of potential markers, and subsequent validation. …”
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    Biomarkers in Colorectal Cancer: The Role of Translational Proteomics Research
  20. 2240
    “…BACKGROUND: This study assessed the psychometric profile of 10 questionnaires (every 6 months, from 6 to 60 months) from the Japanese translation of the Ages and Stages Questionnaires, third edition (J‐ASQ‐3). …”
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    Psychometric profile of the Ages and Stages Questionnaires, Japanese translation
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