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  1. 2281
    por Jacques, Erik, Suuronen, Erik J.
    Publicado 2020
    “…This may be linked to the novelty of these technologies and their disruptive nature, which has brought an increasing level of complexity to translation. Therefore, we look at how the historical development of the RM field has changed the translational strategy. …”
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    The Progression of Regenerative Medicine and its Impact on Therapy Translation
  2. 2282
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    Cancer stemness in hepatocellular carcinoma: mechanisms and translational potential
  3. 2283
    “…These findings highlight the challenges of translating AAV delivery via lumbar puncture to humans and suggest that delivery into the cisterna magna may represent a more feasible alternative.…”
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    Translational Feasibility of Lumbar Puncture for Intrathecal AAV Administration
  4. 2284
    “…Here, we explore this “parameter geography” for bistability in post-translational modification (PTM) systems. We use the previously developed “linear framework” for timescale separation to describe the steady-states of a two-site PTM system as the solutions of two polynomial equations in two variables, with eight non-dimensional parameters. …”
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    Robustness and parameter geography in post-translational modification systems
  5. 2285
    “…Furthermore, the obstacles in the way of clinical translation of optogenetic stimulation are discussed, and suggestions on how they could be overcome are provided. …”
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    Towards the clinical translation of optogenetic skeletal muscle stimulation
  6. 2286
    “…METHODS: The English version of the PISI was translated into Swedish, translated back into English, and agreed upon before use. …”
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    Swedish translation and validation of the Pediatric Insomnia Severity Index
  7. 2287
    “…However, the mission of translating novel HDP-derived molecules from bench to bedside has yet to be fully accomplished, primarily attributed to their intricate structure-activity relationship, toxicity, instability in host and microbial environment, lack of correlation between in vitro and in vivo efficacies, and dwindling interest from large pharmaceutical companies. …”
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    Strategies in Translating the Therapeutic Potentials of Host Defense Peptides
  8. 2288
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    Time-Restricted Eating: Benefits, Mechanisms, and Challenges in Translation
  9. 2289
    por Hiramoto, Masaki, Cline, Hollis T.
    Publicado 2020
    “…Reducing NMDAR responses by 50% inverts the spatial distribution of branch dynamics along the rostrocaudal axis in response to temporal patterns of input, suggesting that the magnitude of NMDAR signaling encodes the temporal sequence of inputs and translates the temporal code into a directional spatial map using structural plasticity-based branch dynamics. …”
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    NMDARs Translate Sequential Temporal Information into Spatial Maps
  10. 2290
    por Ali, Levi, Haynes, Cole M.
    Publicado 2020
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    Mitochondrial translation, dynamics, and lysosomes combine to extend lifespan
  11. 2291
    “…In this review, we illustrate the state of art of phage therapy and examine the role of animal models to translate these treatments to humans.…”
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    Animal Models to Translate Phage Therapy to Human Medicine
  12. 2292
    “…Translation initiation in human mitochondria relies upon specialized mitoribosomes and initiation factors, mtIF2 and mtIF3, which have diverged from their bacterial counterparts. …”
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    Distinct pre-initiation steps in human mitochondrial translation
  13. 2293
    por Cavalieri, Vincenzo
    Publicado 2020
    “…Undoubtedly, the issues addressed in this review take on particular importance in the emerging field of comparative biology of epigenetics, as well as in translational research.…”
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    Histones, Their Variants and Post-translational Modifications in Zebrafish Development
  14. 2294
    por Chen, Ling, Liu, Shuang, Tao, Yongguang
    Publicado 2020
    “…We here review the necessity, characteristics, and mechanisms of each kind of post-translational modification on Rb, p53, PTEN, and its influence on the precise and selective function. …”
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    Regulating tumor suppressor genes: post-translational modifications
  15. 2295
    “…We demonstrate that both endogenous genes and reporter sequences containing long polyA runs are efficiently and accurately translated in P. falciparum cells. We show that polyA runs do not elicit any response from No Go Decay (NGD) or result in the production of frameshifted proteins. …”
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    Plasmodium falciparum translational machinery condones polyadenosine repeats
  16. 2296
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    Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery
  17. 2297
    “…Here we demonstrate a role of translational reprogramming in the survival of asparagine-restricted cancer cells. …”
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    Translational Reprogramming Marks Adaptation to Asparagine Restriction in Cancer
  18. 2298
    por Tobiasson, Victor, Amunts, Alexey
    Publicado 2020
    “…To understand the steps involved in the evolution of translation, we used Tetrahymena thermophila, a ciliate with high coding capacity of the mitochondrial genome, as the model organism and characterized its mitochondrial ribosome (mitoribosome) using cryo-EM. …”
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    Ciliate mitoribosome illuminates evolutionary steps of mitochondrial translation
  19. 2299
    “…RESULTS: Early stage translational researchers reported engagement with a broad array of stakeholders. …”
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    Facilitating stakeholder engagement in early stage translational research
  20. 2300
    “…Control of mRNA translation is a crucial regulatory mechanism used by bacteria to respond to their environment. …”
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    Control of mRNA translation by dynamic ribosome modification
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