“…One proposed role for biomolecular condensates that contain RNA is translation regulation. In several specific contexts, translation has been shown to be modulated by the presence of a phase-separating protein and under conditions which promote phase separation, and likely many more await discovery. …”
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“…In this symposium, translational researchers in geriatric medicine and gerontology will present current work to elucidate biologic underpinnings of aging and potential intervention targets. …”
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“…Kuakini Medical Center (Kuakini) is establishing an interdisciplinary Hawai’i-based Center of Biomedical Research Excellence (COBRE) for clinical and translational research on aging. - Specific Aim 1: Create a world class, innovative, interdisciplinary Center for Translational Research on Aging by building on the existing rare and valuable Kuakini Honolulu Heart Program (Kuakini HHP) and its related studies and research infrastructure. - Specific Aim 2: Advance the genomic, biological and clinical science of aging, and enhance the world class character of our Center, by enlisting accomplished senior scientists to mentor promising Hawaii-based new investigators in interdisciplinary aging research and career development. - Specific Aim 3: Elevate the capacity of our Center by: i) creating a state-of-the-art Clinical and Translational Core, and ii) collaborating with other Centers of Biomedical Research Excellence. …”
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“…We anticipate that this will translate cardiac reprogramming-based heart therapy into clinical applications. …”
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“…“Translational Research” has traditionally been defined as taking basic scientific findings and developing new diagnostic tools, drugs, devices and treatment options for patients, that are translated into practice, reach the people and populations for whom they are intended and are implemented correctly. …”
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“…The purpose of this study was to translate and conduct psychometric testing of the MISSCARE Survey. …”
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“…Here we reveal linezolid, an oxazolidinone antibiotic that inhibits microbial translation, is also herbicidal. To validate the herbicidal mode of action of linezolid we confirmed its micromolar inhibition is specific to chloroplast translation and did not affect photosynthesis directly. …”
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“…Polygenic risk scores (PRSs) are heralded as useful tools for risk stratification and personalized preventive care, but they are clinically useful only if they can be translated into action. The risk information conveyed by a PRS must be contextualized to enable this. …”
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“…AIM: To validate the Croatian translation of the Body Image Scale in breast cancer and chronic kidney disease patients. …”
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“…Mechanistically, cisplatin inhibits cellular translation to promote disassembly of polysomes and aggregation of ribosomal subunits. …”
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“…A blueprint for engineering the next generation of bioinks that satisfy the aforementioned performance criteria for various translational levels (TRL1‐5) and a characterization tool kit is presented.…”
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“…The amplitudes of perceived tilt and translation were expressed in terms of gain, i.e., the ratio of perceived tilt to equivalent tilt angle, and the ratio of perceived translation to equivalent linear displacement. …”
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“…However, it is not trivial to visualize post-translational modifications in a protein- and site-specific manner, especially in a living-cell context. …”
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“…ABSTRACT IMPACT: Leverage community engagement to continue moving translational science and research forward. OBJECTIVES/GOALS: Engaging community in translational research improves innovation and speeds the movement of evidence into practice. …”
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