“…How can we start closing this gap and rationally guide the translation of tDCS into the field of obesity? In this mini-review I summarize some of the challenges and questions ahead, related to basic science and technical aspects, and suggest future directions.…”
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“…We developed workflow models for a translational research study in psychiatry and the clinic where its data collection was carried out. …”
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“…BACKGROUND: Knowledge translation (KT) aims to close the research-practice gap in order to realize and maximize the benefits of research within the practice setting. …”
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“…In this article, we review what is currently known about RAN translation and recent progress toward understanding its contribution to disease.…”
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“…The systems biology methods and applications covered in this review provide a framework for addressing disease mechanism and approaching drug discovery, which will facilitate the translation of research findings into clinical benefits such as novel biomarkers and promising therapies.…”
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“…Activation of the PI3K/Akt/mTOR and MEK/ERK pathways mediated the effect of EGF-induced translational up-regulation. Besides, only the splicing variants containing exon 2 of Aurora-A mRNA showed increased interaction with the translational complex to synthesize Aurora-A protein under EGF stimulus. …”
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“…These recent developments are reviewed in the current Special Issues Series on “Current concepts in Alzheimer's disease research: molecules, models and translational perspectives” in a number of state-of-the-art manuscripts.…”
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“…These findings have implications for how we understand the translation of new knowledge into practice and its transfer across different clinical communities and settings. …”
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“…Given the fact that efficient translation of valuable information embedded in brain scans into clinical application is of paramount scientific and public health importance, a strategy is needed to bridge the current gap between imaging and molecular biology, particularly in neurodegenerative diseases. …”
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“…Namely, recent experimental approaches mixing neural units and local field potentials recordings have demonstrated a spike timing dependent plasticity by which the cerebellum remains at a strategic crossroad for deciphering fundamental and translational mechanisms from cellular to network levels.…”
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“…Interestingly, the p53 level is controlled by post-translational regulation rather than transcriptional regulation in this feedback mechanism. …”
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“…This study using social network analysis to ask: (1) Who are the key players of a new translational research network (TRN)? (2) Do they have characteristics in common? …”
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“…We are at the dawn of predictive, preventive, personalized, and participatory (P4) medicine, the fully implementation of which requires marrying basic and clinical researches through advanced systems thinking and the employment of high-throughput technologies in genomics, proteomics, nanofluidics, single-cell analysis, and computation strategies in a highly-orchestrated discipline we termed translational systems medicine.…”
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“…The precursor protein, pro-opiomelanocortin (POMC) undergoes extensive post-translational processing in a tissue-specific manner to yield various biologically active peptides involved in diverse cellular functions. …”
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“…BACKGROUND: Given that toxicology studies the potential adverse effects of environmental exposures on various forms of life and that clinical toxicology typically focuses on human health effects, what can and should the relatively new term of "translational toxicology" be taken to mean? DISCUSSION: Our assertion is that the core concept of translational toxicology must incorporate existing principles of toxicology and epidemiology, but be driven by the aim of developing safe and effective interventions beyond simple reduction or avoidance of exposure to prevent, mitigate or reverse adverse human health effects of exposures. …”
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“…MATERIALS AND METHODS: The SRPB facets were translated into Hindi using the World Health Organisation's translation methodology. …”
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“…The International Society for Stem Cell Research hosted an exciting meeting on stem cell-based translational medicine in Florence, Italy in September 2013. …”
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“…Protein translation is the most expensive operation in dividing cells from bacteria to humans. …”
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“…OBJECTIVES: To understand the formal roles of community representatives (CRs) in Clinical and Translational Science Awardee (CTSA) activities, to evaluate the extent of integration into the organizational and governance structures and to identify barriers to effective integration. …”
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