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3041por Hosmillo, Myra, Sweeney, Trevor R., Chaudhry, Yasmin, Leen, Eoin, Curry, Stephen, Goodfellow, Ian, Cho, Kyoung-Oh“…Here, we investigated the role of eIF4A in porcine sapovirus VPg-dependent translation. Using inhibitors and dominant-negative mutants, we found that eIF4A is required for viral translation and infectivity, suggesting that despite the presence of a very short 5′ UTR, eIF4A is required to unwind RNA structure in the sapovirus genome to facilitate virus translation.…”
Publicado 2016
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3042por Almeida, Carlos Manuel Torres, Almeida, Filipe Nuno Alves dos Santos, Escola, Joaquim José Jacinto, Rodrigues, Vitor Manuel Costa Pereira“…METHODS: the following methodological steps were taken: bibliographic review, selection of the scales, translation and cultural adaptation and analysis of psychometric properties. …”
Publicado 2016
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3043“…Hence, this theoretical article draws attention to the clinical applicability of studies about maternal behavior in animals to psychobiology, taking into account a translational perspective.…”
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3044
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3045
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3046“…Pathogens, especially viruses, evolve abilities to utilize cellular machineries to facilitate their survival and propagation. Post-translational modifications (PTMs), especially phosphorylation and SUMOylation, that reversibly modulate the function and interactions of target proteins are among the most important features in cell signaling pathways. …”
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3047por Luce, Mikael-Jonathan, Akpawu, Anna Akuvi, Tucunduva, Daniel C., Mason, Spencer, Scott, Michelle S.“…While the use of protein targeting motifs is modulated in a post-translational manner, mainly by protein conformational changes and post-translational modifications, the presence of these motifs in proteins can also be regulated in a pre-translational manner. …”
Publicado 2016
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3048
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3049por Liu, Yuchen, Chen, Zhicong, He, Anbang, Zhan, Yonghao, Li, Jianfa, Liu, Li, Wu, Hanwei, Zhuang, Chengle, Lin, Junhao, Zhang, Qiaoxia, Huang, Weiren“…Recently CRISPR-Cas9 system has been reported to be capable of targeting a viral RNA, and this phenomenon thus raises an interesting question of whether Cas9 can also influence translation of cellular mRNAs. Here, we show that both natural and catalytically dead Cas9 can repress mRNA translation of cellular genes, and that only the first 14 nt in the 5′ end of sgRNA is essential for this process. …”
Publicado 2016
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3051por Couvillion, Mary T., Soto, Iliana C., Shipkovenska, Gergana, Churchman, L. Stirling“…Furthermore, the coordinated translation programs are controlled unidirectionally through the intricate and dynamic control of cytosolic translation. …”
Publicado 2016
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3052“…Evidence now reveals that the ability of RIP1 and RIP3 to modulate this key cellular event is tightly controlled by post-translational modifications, including ubiquitination, phosphorylation, caspase 8-mediated cleavage and GlcNAcylation. …”
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3054por Battersby, Anna J., Khara, Jasmeet, Wright, Victoria J., Levy, Ofer, Kampmann, Beate“…Further studies should characterize the ontogeny of antimicrobial activity in mucosal and systemic compartments, and examine the efficacy of exogenous-APP formulations to inform translational development of APPs for infant groups.…”
Publicado 2016
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3055“…It is generally believed that introns are not translated; therefore, the potential intronic features that may be related to the translation step (occurring after splicing) have yet to be thoroughly studied. …”
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3056“…The present longitudinal study was intended to investigate whether the two bilingual experiences of written translation and consecutive interpreting (featured with similar language switching experience but different processing demands) would produce different cognitive control effects in young adults. …”
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3057por Wong, Connie HYEnlace del recurso
Publicado 2016
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3058por Griffith, May, Islam, Mohammad M., Edin, Joel, Papapavlou, Georgia, Buznyk, Oleksiy, Patra, Hirak K.“…Therefore, now it is of utmost importance to develop integrative biomaterials based on multifunctional biopolymers and nanosystem for their practical and successful clinical translation.…”
Publicado 2016
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3059“…Translation is carefully regulated to control protein levels and allow quick responses to changes in the environment. …”
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3060por Westfall, Margaret V.“…Secondary shifts develop in post-translational phosphorylation of sarcomeric proteins in multiple animal models of inherited cardiomyopathy. …”
Publicado 2016
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