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3061por Bertolin, Agustina P., Katz, Maximiliano J., Yano, Masato, Pozzi, Berta, Acevedo, Julieta M., Blanco-Obregón, Dalmiro, Gándara, Lautaro, Sorianello, Eleonora, Kanda, Hiroshi, Okano, Hideyuki, Srebrow, Anabella, Wappner, Pablo“…Genetic interaction assays suggested that dMusashi participates of the HIF pathway, and molecular studies carried out in Drosophila cell cultures showed that dMusashi recognizes a Musashi Binding Element in the 3′ UTR of the HIFα transcript, thereby mediating its translational repression in normoxia. In hypoxic conditions dMusashi is downregulated, lifting HIFα repression and contributing to trigger HIF-dependent gene expression. …”
Publicado 2016
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3062“…Precision Medicine may be considered as another strategic effort of “from-bench-to-beside” translation. In order to have a maximal impact on population health, the translation must go further. …”
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3063por Lewis, Kevin M., Munske, Gerhard R., Byrd, Samuel S., Kang, Jeehoon, Cho, Hyun-Jai, Ríos, Eduardo, Kang, ChulHee“…To determine the significance and universal profile of these post-translational modifications to mammalian calsequestrin, we characterized, via mass spectrometry, the glycosylation and phosphorylation of skeletal muscle calsequestrin from cattle (B. taurus), lab mice (M. musculus) and lab rats (R. norvegicus) and cardiac muscle calsequestrin from cattle, lab rats and humans. …”
Publicado 2016
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3068An epigenomics approach to individual differences and its translation to neuropsychiatric conditionsMaterias: “…Translational Research…”
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3069por Oliveira, Camila, Carvalho, Paulo Costa, Alves, Lysangela Ronalte, Goldenberg, Samuel“…In summary, the results indicate that TcNRBD1 is associated with different parts of the translation process, either by regulating mRNAs that encode ribosomal proteins or by acting in some step of ribosome assembly in T. cruzi.…”
Publicado 2016
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3076“…RESULTS: Research in the last decade indicates that RNA-binding proteins (RBPs) responsible for mRNA localization, stability and translation mediate local expression control. Among others, they are affected by mTOR and MAPK to guide expression of epileptic factors. …”
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3078“…There is therefore an identified need to model co-morbidities preclinically to allow better translation from bench to bedside. In preclinical studies, both diet-induced and genetically obese rodents have worse stroke outcome, characterised by increased ischaemic damage and an altered inflammatory response. …”
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3079por Gold, E. Richard“…Translational research is often afflicted by a fundamental problem: a limited understanding of disease mechanisms prevents effective targeting of new treatments. …”
Publicado 2016
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3080