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3361“…This article reviews stakeholder engagement, provides several examples of its application across the range of translational research, and recommends that Clinical Translational Science Awards, with their unique geographical, systems, and historical characteristics, actively participate in deepening our understanding of stakeholder engagement science and methods within implementation and dissemination research. …”
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3362“…Since these events occur in the absence of transcription, they require cascades of successive unmasking, translation, and discarding of these mRNAs, implying a fine regulation of the timing of specific translation. …”
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3363“…These processes are tightly regulated by coordinated mechanisms, including post-translational modifications (PTMs). The fine-tuning modulation of the balance between the proteins, responsible for PTMs, is essential to maintain genome integrity and to prevent tumorigenesis. …”
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3364por Ede, James D., Lobaskin, Vladimir, Vogel, Ulla, Lynch, Iseult, Halappanavar, Sabina, Doak, Shareen H., Roberts, Megan G., Shatkin, Jo AnneEnlace del recurso
Publicado 2020
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3365“…Recent work has begun to focus on the regulation of Smurf2 itself, and emerging evidence indicates that Smurf2 is regulated by post-translational modifications (PTMs) mechanisms. These mechanisms predominantly regulate the expression level and E3 ligase activity of Smurf2, strongly suggesting that this protein contributes to complicated roles under multiple pathophysiological conditions. …”
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3366por Ninomiya, Kota, Takatsuki, Terue, Kushida, Tatsuya, Yamamoto, Yasunori, Ogishima, Soichi“…For clinicians who are not fluent in English, the HPO has been translated into many languages, and there have been four initiatives to develop Japanese translations. …”
Publicado 2020
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3367por Deutschman, Clifford S., Hellman, Judith, Ferrer Roca, Ricard, De Backer, Daniel, Coopersmith, Craig M.“…OBJECTIVES: Expound upon priorities for basic/translational science identified in a recent paper by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine. …”
Publicado 2020
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3368por Deutschman, Clifford S., Hellman, Judith, Roca, Ricard Ferrer, De Backer, Daniel, Coopersmith, Craig M.“…OBJECTIVES: Expound upon priorities for basic/translational science identified in a recent paper by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine. …”
Publicado 2020
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3369“…One of the challenges in translating new therapeutic approaches to the patient bedside lies in bridging the gap between scientists who are conducting basic laboratory research and medical practitioners who are not exposed to highly specialized journals. …”
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3370Determinants of translation efficiency in the evolutionarily-divergent protist Trichomonas vaginalis“…The specific mechanisms adopted by T. vaginalis to fine-tune the translation efficiency (TE) of mRNAs remain largely unknown. …”
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3371por López García de Lomana, Adrián, Kusebauch, Ulrike, Raman, Arjun V., Pan, Min, Turkarslan, Serdar, Lorenzetti, Alan P. R., Moritz, Robert L., Baliga, Nitin S.“…In order to generate proteins for the new quiescent physiological state, we hypothesized that the translation machinery must selectively translate upregulated transcripts in an intracellular milieu crowded with considerably higher abundance transcripts from the previous active growth state. …”
Publicado 2020
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3372
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3373por Sun, Li, Zhang, Wenjie, Zhao, Yanfang, Wang, Fengge, Liu, Shan, Liu, Lei, Zhao, Lin, Lu, Wei, Li, Minghui, Xu, YuekangEnlace del recurso
Publicado 2020
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3374“…How does cyberculture impact legal translation?…”
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3375
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3376“…Therefore, identifying biomarkers involved in tumorigenesis and progression represents a challenge for cancer diagnosis and therapeutic strategy development. The eukaryotic translation factor 5A (eIF5A), originally identified as an initiation factor, was later shown to promote translation elongation of iterated proline sequences. …”
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3377por Botting, K. J., Skeffington, K. L., Niu, Y., Allison, B. J., Brain, K. L., Itani, N., Beck, C., Logan, A., Murray, A. J., Murphy, M. P., Giussani, D. A.“…However, research in species with developmental milestones comparable to humans is lacking, preventing translation of this knowledge to clinical contexts. …”
Publicado 2020
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3378
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3379“…Modular parts for tuning translation are prevalent in prokaryotic synthetic biology but lacking for eukaryotic synthetic biology. …”
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3380“…CONCLUSION: Further translational work is needed to identify the causal relationship between circadian physiology abnormalities and mental disorders and related psychopathology, and to develop sound pharmacologic interventions.…”
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