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3401por Montpetit-Tourangeau, Katherine, Kairy, Dahlia, Ahmed, Sara, Anaby, Dana, Bussières, André, Lamontagne, Marie-Ève, Rochette, Annie, Shikako-Thomas, Keiko, Thomas, Aliki“…A strategic initiative that ensures the relevance of the research and its implementation in the context of rehabilitation could 1) help improve the coordination of knowledge translation (KT) research and 2) enhance the delivery of evidence-based rehabilitation services offered to patients with physical disabilities. …”
Publicado 2020
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3402
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3403por Packialakshmi, Balamurugan, Stewart, Ian J., Burmeister, David M., Chung, Kevin K., Zhou, Xiaoming“…While extensive research using animal models has improved the understanding of acute kidney injury (AKI), this knowledge has not been translated into effective treatments. Many promising interventions for AKI identified in mice and rats have not been validated in subsequent clinical trials. …”
Publicado 2020
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3404por Cecchetti, Alfred A, Bhardwaj, Niharika, Murughiyan, Usha, Kothakapu, Gouthami, Sundaram, Uma“…CONCLUSIONS: The platform provides an inexpensive yet seamless way to translate clinical and translational research ideas into clinical applications for regions similar to Appalachia that have limited resources and a largely rural population.…”
Publicado 2020
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3405por Harsanyi, Szilvia, Balogh, Nandor, Kolozsvari, Laszlo Robert, Mezes, Laszlo, Papp, Csaba, Zsuga, Judit“…BACKGROUND: Translating clinical guidelines into routine clinical practice is mandatory to achieve population level improvement of health. …”
Publicado 2020
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3406“…In this review, we discuss the significant translational and clinical advances in the field which have evolved based on a better understanding of transplant immunology. …”
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3407por Wood, Henry P., Cruz-Navarrete, F. Aaron, Baxter, Nicola J., Trevitt, Clare R., Robertson, Angus J., Dix, Samuel R., Hounslow, Andrea M., Cliff, Matthew J., Waltho, Jonathan P.“…Herein, we describe allomorphy, a post-translational control mechanism of enzyme activity. In βPGM, isomerisation of the K145-P146 peptide bond results in the population of two conformers that have different activities owing to repositioning of the K145 sidechain. …”
Publicado 2020
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3408por Absmeier, Eva, Chandrasekaran, Viswanathan, O’Reilly, Francis J, Stowell, James AW, Rappsilber, Juri, Passmore, Lori A“…Translation impacts mRNA stability and, in yeast, this is mediated by the Ccr4-Not deadenylation complex. …”
Publicado 2023
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3409por Hao, Peiqi, Yu, Jiaojiao, Ward, Richard, Liu, Yin, Hao, Qiao, An, Su, Xu, Tianrui“…The regulation of the translation of messenger RNA (mRNA) in eukaryotic cells is critical for gene expression, and occurs principally at the initiation phase which is mainly regulated by eukaryotic initiation factors (eIFs). eIFs are fundamental for the translation of mRNA and as such act as the primary targets of several signaling pathways to regulate gene expression. …”
Publicado 2020
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3410“…This article is an abridged and translated version of the guideline published in Nervenarzt: Diener, HC., für die Deutsche Gesellschaft für Neurologie (DGN), Grau, A.J. et al. …”
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3411por Puray-Chavez, Maritza, Lee, Nakyung, Tenneti, Kasyap, Wang, Yiqing, Vuong, Hung R., Liu, Yating, Horani, Amjad, Huang, Tao, Gunsten, Sean P., Case, James B., Yang, Wei, Diamond, Michael S., Brody, Steven L., Dougherty, Joseph, Kutluay, Sebla B.“…SARS-CoV-2 utilizes a number of strategies to modulate viral and host mRNA translation. Here, we used ribosome profiling in SARS-CoV-2 infected model cell lines and primary airway cells grown at the air-liquid interface to gain a deeper understanding of the translationally regulated events in response to virus replication. …”
Publicado 2021
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3412“…The first part included a translation and a cultural-linguistic adaptation of the Bulgarian version of BCTQ. …”
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3413“…Recently, various post-translational modifications (PTMs) of cGAS have been reported, such as phosphorylation, ubiquitination, acetylation, glutamylation, and sumoylation. …”
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3414
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3415
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3416“…Translation initiation is a key step in the protein synthesis stage of the gene expression pathway of all living cells. …”
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3417“…Conclusion: Ours is the first translation and cross-cultural adaptation of the CMS into Arabic. …”
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3418“…Like other post-translational modifications (PTMs) of proteins, S-nitrosylation has been considered a key regulatory mechanism of multiple cellular functions in many physiological and disease conditions. …”
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3419por Guerra-Castellano, Alejandra, Márquez, Inmaculada, Pérez-Mejías, Gonzalo, Díaz-Quintana, Antonio, De la Rosa, Miguel A., Díaz-Moreno, Irene“…Such a dual role of cytochrome c in cell life and death is indeed fine-regulated by a wide variety of protein post-translational modifications. In this work, we show how these modifications can alter cytochrome c structure and functionality, thus emerging as a control mechanism of cell metabolism but also as a key element in development and prevention of pathologies.…”
Publicado 2020
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3420por Adhikari, Abhinav, Vilkhovoy, Michael, Vadhin, Sandra, Lim, Ha Eun, Varner, Jeffrey D.“…Transcription and translation are at the heart of metabolism and signal transduction. …”
Publicado 2020
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