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3441por Moldogazieva, Nurbubu T., Mokhosoev, Innokenty M., Zavadskiy, Sergey P., Terentiev, Alexander A.“…We show that currently available computational platforms for big data analysis and AI technologies can both enhance proteomic profiling and improve imaging techniques to enhance the translational application of proteomics data into precision medicine.…”
Publicado 2021
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3442
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3443por Minati, Luca, Firrito, Claudia, Del Piano, Alessia, Peretti, Alberto, Sidoli, Simone, Peroni, Daniele, Belli, Romina, Gandolfi, Francesco, Romanel, Alessandro, Bernabo, Paola, Zasso, Jacopo, Quattrone, Alessandro, Guella, Graziano, Lauria, Fabio, Viero, Gabriella, Clamer, Massimiliano“…Using AHARIBO in mouse embryonic stem cells during neuronal differentiation, we isolated ribosome-protected RNA fragments, translated RNAs, and corresponding de novo synthesized peptides. …”
Publicado 2021
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3444
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3445“…riboCIRC is a translatome data-oriented circRNA database specifically designed for hosting, exploring, analyzing, and visualizing translatable circRNAs from multi-species. The database provides a comprehensive repository of computationally predicted ribosome-associated circRNAs; a manually curated collection of experimentally verified translated circRNAs; an evaluation of cross-species conservation of translatable circRNAs; a systematic de novo annotation of putative circRNA-encoded peptides, including sequence, structure, and function; and a genome browser to visualize the context-specific occupant footprints of circRNAs. …”
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3446
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3447por Lee, David S. M., Park, Joseph, Kromer, Andrew, Baras, Aris, Rader, Daniel J., Ritchie, Marylyn D., Ghanem, Louis R., Barash, Yoseph“…Ribosome-profiling has uncovered pervasive translation in non-canonical open reading frames, however the biological significance of this phenomenon remains unclear. …”
Publicado 2021
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3448“…In this review, we discuss how OCM impacts the translation apparatus (composed of ribosome, tRNA, mRNA, and translation factors) and regulates crucial steps in protein synthesis. …”
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3449
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3450
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3451
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3452por Bugyi, Fanni, Szabó, Dániel, Szabó, Győző, Révész, Ágnes, Pape, Veronika F. S., Soltész-Katona, Eszter, Tóth, Eszter, Kovács, Orsolya, Langó, Tamás, Vékey, Károly, Drahos, László“…[Image: see text] Comprehensive analysis of post-translation modifications (PTMs) is an important mission of proteomics. …”
Publicado 2021
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3453“…In humans and other eukaryotes, histone post-translational modifications (hPTMs) play an essential role in the epigenetic control of gene expression. …”
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3454por Grewal, Thomas, Rentero, Carles, Enrich, Carlos, Wahba, Mohamed, Raabe, Carsten A., Rescher, Ursula“…Traits that are only associated with advanced developmental stages can now be investigated within a living organism, and the in vivo analysis of corresponding phenotypes and functions advances the translation into the clinical setting. The annexins, a family of closely related calcium (Ca(2+))- and lipid-binding proteins, are found at various intra- and extracellular locations, and interact with a broad range of membrane lipids and proteins. …”
Publicado 2021
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3455por Liu, Shanshan, Zhou, Guangjin, Xu, Nanfang, Mai, Shuo, Wang, Qi, Zeng, Lin, Du, Chaojun, Du, Yaoxu, Zeng, Yan, Yu, Miao, Liu, Zhongjun“…The current study aimed to culturally adapt and psychometrically validate the BrQ in contemporary Chinese used in mainland China. METHODS: Translation of the BrQ from the original Greek into Chinese was performed. …”
Publicado 2021
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3456
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3457por Moaddel, Ruin, Ubaida‐Mohien, Ceereena, Tanaka, Toshiko, Lyashkov, Alexey, Basisty, Nathan, Schilling, Birgit, Semba, Richard D, Franceschi, Claudio, Gorospe, Myriam, Ferrucci, Luigi“…Circulating proteins are ideal translational “omics” since they are final effectors of physiological pathways and because physicians are accustomed to use information of plasma proteins as biomarkers for diagnosis, prognosis, and tracking the effectiveness of treatments. …”
Publicado 2021
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3458por Yagi, Mikako, Toshima, Takahiro, Amamoto, Rie, Do, Yura, Hirai, Haruka, Setoyama, Daiki, Kang, Dongchon, Uchiumi, Takeshi“…Mitochondrial translation dysfunction is associated with neurodegenerative and cardiovascular diseases. …”
Publicado 2021
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3459por Senerat, Araliya M., Manemann, Sheila M., Clements, Nicholas S., Brook, Robert D., Hassett, Leslie C., Roger, Véronique L.“…CONCLUSIONS: This review will guide the selection of biomarkers for translational studies evaluating the impact of indoor air pollutants on human health.…”
Publicado 2020
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3460“…INTRODUCTION: Rigor and reproducibility are two important cornerstones of medical and scientific advancement. Clinical and translational research (CTR) contains four phases (T1–T4), involving the translation of basic research to humans, then to clinical settings, practice, and the population, with the ultimate goal of improving public health. …”
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