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3641por Caplan, Arnold I.“…Mesenchymal stem cells were developed as a cell-based therapeutic in the 1990’s. The translation of culture expanded mesenchymal stem cells from a basic science focus into a modern therapeutic has taken 30 years. …”
Publicado 2021
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3642por Li, Yuan, Li, Yucong, Li, Linlong, Wang, Haixing, Wang, Bin, Feng, Lu, Lin, Sien, Li, Gang“…The challenges and future perspectives of GDF11-based therapy for chronic wound care are also discussed. The Translational Potential of this Article: This review summarized the significance of GDF11 in the modulation of inflammation, vascularization, cell proliferation, and remodeling, which are important physiological processes of chronic wound healing. …”
Publicado 2022
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3643“…Recent evidence suggests that LDI can reprogramme the tumor microenvironment, induce inflammation and turn cold tumors susceptible to immunecheckpoint blockade therapy. Translating immuno-radiation preclinical findings in the clinic is more challenging than expected. …”
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3644“…In either scenario, post-translational modifications (PTMs) on DPCs play essential and versatile roles in orchestrating the repair routes. …”
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3645“…Moreover, the review provides some considerations and perspectives in the research and development of nanomedicines to facilitate their translations in clinic.…”
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3646
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3647por Komar, Anton A.“…Protein folding in the cell is largely a co-translational process occurring during protein synthesis on the ribosome. …”
Publicado 2022
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3648“…Due to the experimental challenges to pinpoint translation events and to detect the produced peptides, translational regulation through regulatory RNAs is not well studied yet. …”
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3649por Sadekar, Shraddha S., Bowen, Mayumi, Cai, Hao, Jamalian, Samira, Rafidi, Hanine, Shatz‐Binder, Whitney, Lafrance‐Vanasse, Julien, Chan, Pamela, Meilandt, William J., Oldendorp, Amy, Sreedhara, Alavattam, Daugherty, Ann, Crowell, Susan, Wildsmith, Kristin R., Atwal, Jasvinder, Fuji, Reina N., Horvath, Joshua“…Such models can facilitate delivery device design and pharmacokinetic/pharmacodynamic translation from preclinical species to humans in order to optimize CSF drug delivery to brain regions of interest.…”
Publicado 2022
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3650“…In central nervous system drug discovery programs, early development of new chemical entities (NCEs) requires a multidisciplinary strategy and a translational approach to obtain proof of distribution, proof of occupancy, and proof of function in specific brain circuits. …”
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3651“…While big data has translated to benefit for some patients, it has also created new problems. …”
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3652por Petkova, Stela P., Adhikari, Anna, Berg, Elizabeth L., Fenton, Timothy A., Duis, Jessica, Silverman, Jill L.“…Our hypothesis is that gait presents a strong opportunity for a reliable, quantitative, and translational metric that can serve to evaluate novel pharmacological, dietary, and genetic therapies. …”
Publicado 2022
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3654
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3655
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3656por Fosse, Vibeke, Oldoni, Emanuela, Gerardi, Chiara, Banzi, Rita, Fratelli, Maddalena, Bietrix, Florence, Ussi, Anton, Andreu, Antonio L., McCormack, Emmet“…To achieve a broad implementation of predictive translational models in personalized medicine, these fundamental deficits must be addressed.…”
Publicado 2022
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3657por Walker, Suellen M.“…Though it is clear that multiple psychosocial, family, and environmental factors may influence CPSP, this review will focus on parallels between clinical observations and translational laboratory studies investigating the acute and long-term effects of surgical injury on nociceptive pathways. …”
Publicado 2021
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3658“…BACKGROUND: While the evolutionary divergence of cis-regulatory sequences impacts translation initiation sites (TISs), the implication of tandem repeats (TRs) in TIS selection remains largely elusive. …”
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3659“…In order to alleviate the problem of over translation and missing translation in NMT, based on the consistency and complementarity of information stored in different covering models, a multicoverage fusion model is proposed, which uses coverage vector and coverage score to guide the attention mechanism at the same time. …”
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3660“…However, the development of novel bioresorbable stents accompanied by clinical translation remains time-consuming and challenging. …”
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