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702“…BACKGROUND: The growing consensus that most valuable data source for biomedical discoveries is derived from human samples is clearly reflected in the growing number of translational medicine and translational sciences departments across pharma as well as academic and government supported initiatives such as Clinical and Translational Science Awards (CTSA) in the US and the Seventh Framework Programme (FP7) of EU with emphasis on translating research for human health. …”
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703“…However, to increase the use of SBGN, tools for editing, validating and translating SBGN maps are desirable. Results: We present SBGN-ED, a tool which allows the creation of all three types of SBGN maps from scratch or the editing of existing maps, the validation of these maps for syntactical and semantical correctness, the translation of networks from the KEGG and MetaCrop databases into SBGN and the export of SBGN maps into several file and image formats. …”
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704“…We find that the cloud-based analysis compares favorably in both performance and cost in comparison to a local computational cluster, suggesting that cloud computing technologies might be a viable resource for facilitating large-scale translational research in genomic medicine.…”
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705“…In developing an integrated framework for translational bioinformatics, we consider bioimaging in the NIH Roadmap that exploits high-resolution genomic imaging for clinical applications to the diagnosis and treatment of genetic disorders/diseases. …”
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706
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707por Basu, Utpal, Lozynska, Olga, Moorwood, Catherine, Patel, Gopal, Wilton, Steve D., Khurana, Tejvir S.“…METHODOLOGY/PRINCIPAL FINDINGS: Using a variety of bioinformatic, molecular and cell biology techniques, we show that the muscle isoform utrophin-A is predominantly suppressed at the translational level in C2C12 myoblasts. The extent of translational inhibition is estimated to be ∼99% in C2C12 cells and is mediated by both the 5′- and 3′-UTRs of the utrophin-A mRNA. …”
Publicado 2011
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708por Chiong, M, Wang, Z V, Pedrozo, Z, Cao, D J, Troncoso, R, Ibacache, M, Criollo, A, Nemchenko, A, Hill, J A, Lavandero, S“…In addition, we highlight the involvement of these mechanisms in cardiac pathology and discuss potential translational implications.…”
Publicado 2011
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709“…The present article elucidates some of the difficulties in translating research from bench to bedside.…”
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710
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711“…Viruses have adapted a broad range of unique mechanisms to modulate the cellular translational machinery to ensure viral translation at the expense of cellular protein synthesis. …”
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712por Frank, Joachim“…The recently solved X-ray crystal structures of the ribosome have provided opportunities for studying the molecular basis of translation with a variety of methods including cryo-electron microscopy - where maps give the first glimpses of ribosomal evolution - and fluorescence spectroscopy techniques.…”
Publicado 2003
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713
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714
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715
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716“…Neuropathic pain develops from a lesion or disease affecting the somatosensory system. Translational investigations of neuropathic pain by using different animal models reveal that peripheral sensitization, spinal and cortical plasticity may play critical roles in neuropathic pain. …”
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717“…Recent studies on the molecular mechanisms of inflammatory responses and haematological disorders indicate clearly that the regulation of mRNA translation at the level of translation initiation, mRNA stability, and protein isoform synthesis is implicated in the tight regulation of gene expression. …”
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718“…In this review, we will discuss that diversity also exists in a key biochemical process, translation, across eukaryotes. Translation is a fundamental process for all forms of life, and the basic components and mechanisms of translation in eukaryotes have been largely established upon the study of traditional, so-called model organisms. …”
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719
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720por Agrawal, A, Verweij, K J H, Gillespie, N A, Heath, A C, Lessov-Schlaggar, C N, Martin, N G, Nelson, E C, Slutske, W S, Whitfield, J B, Lynskey, M T“…This selective review outlines and highlights the need for a multi-method translational approach to genetic studies of these important conditions, including both licit (alcohol, nicotine) and illicit (cannabis, cocaine, opiates) drug addictions and the behavioral addiction of disordered gambling. …”
Publicado 2012
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