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841
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842por Spoel, Steven HEnlace del recurso
Publicado 2018
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843
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844por Kreindler, Sara A.“…BACKGROUND: Integrated knowledge translation (IKT) flows from the premise that knowledge co-produced with decision-makers is more likely to inform subsequent decisions. …”
Publicado 2018
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845“…The second type are translationally repressed by a novel ribosome-binding protein, interferon-related developmental regulator 2 (IFRD2), which spans the P and E sites and inserts a C-terminal helix into the mRNA exit channel to preclude translation. …”
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846por Calamita, Piera, Gatti, Guido, Miluzio, Annarita, Scagliola, Alessandra, Biffo, Stefano“…Ribosomes have been long considered as executors of the translational program. The fact that ribosomes can control the translation of specific mRNAs or entire cellular programs is often neglected. …”
Publicado 2018
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847por Bray, Marcus S., Lenz, Timothy K., Haynes, Jay William, Bowman, Jessica C., Petrov, Anton S., Reddi, Amit R., Hud, Nicholas V., Williams, Loren Dean, Glass, Jennifer B.“…Then, we used in vitro translation reactions to test whether Fe(2+) or Mn(2+) could mediate protein production, and quantified ribosomal metal content. …”
Publicado 2018
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849por O’Donnell, Marie AnneEnlace del recurso
Publicado 2019
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850por Tatonetti, Nicholas P“…The ability to collect, store and analyze massive amounts of molecular and clinical data is fundamentally transforming the scientific method and its application in translational medicine. Collecting observations has always been a prerequisite for discovery, and great leaps in scientific understanding are accompanied by an expansion of this ability. …”
Publicado 2017
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851“…While HIFs are well known for their transcriptional functions, they also play imperative roles in translation to mediate hypoxic protein synthesis. Such adaptations to hypoxia are often hyperactive in solid tumors, contributing to the expression of cancer hallmarks, including treatment resistance. …”
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852por Tatullo, Marco, Codispoti, Bruna, Paduano, Francesco, Nuzzolese, Manuel, Makeeva, Irina“…To date, researchers are working on effective and efficient methods to ensure safe and predictable protocols to translate stem cell research into human models. In the last decades, the challenge has been to finally use oral-derived stem cells together with biomaterials or scaffold-free techniques, to obtain strategic tools for regenerative and translational dentistry. …”
Publicado 2019
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853“…Ubiquitination regulates many essential cellular processes in eukaryotes. This post-translational modification (PTM) is typically achieved by E1, E2, and E3 enzymes that sequentially catalyze activation, conjugation, and ligation reactions, respectively, leading to covalent attachment of ubiquitin, usually to lysine residues of substrate proteins. …”
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854“…We define the Uhlmann number as an extension of the Chern number, and we use this quantity to describe the topology of 2D translational invariant Fermionic systems at finite temperature. …”
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855“…Members of the MYC family of oncogenes are master regulators of mRNA translation. In this issue of JEM, Singh et al. (https://doi.org/10.1084/jem.20181726) demonstrate that c-Myc governs protein synthesis in lymphoma cells by interfering with SRSF1- and RBM42-mediated suppression of mRNA translation and by altering selection of translation initiation sites.…”
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856“…The creation of an open access journal, such as Translational Respiratory Medicine, dedicated to translational respiratory research can help foster progress.…”
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857“…Initiation and upkeep of this balancing act is mainly under the control of kinases that affect the propensity and selectivity of protein translation. This review will focus on kinases in pathogenic fungi that facilitate a virulence phenotype through translational control.…”
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858por Newman, John C., Sokoloski, Julie L., Robbins, Paul D., Niedernhofer, Laura J., Reed, May J., Wei, Jeanne, Austad, Steven N., Barzilai, Nir, Cohen, Harvey Jay, Kuchel, George A., Kirkland, James L., Pignolo, Robert J.“…Geriatrician investigators are indispensable but cannot meet the need alone. Translational geroscience training programs can create a cadre of groundbreaking investigators from a variety of backgrounds and foster institutional cultures supportive of multidisciplinary translational aging research to turn innovative ideas into transformative therapeutics that can improve the health and independence of older adults. …”
Publicado 2019
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859“…Fundamental scientific advances can take decades to translate into improvements in human health. Shortening this interval would increase the rate at which scientific discoveries lead to successful treatment of human disease. …”
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860“…It is expected that the benefits of translational research in this disease will extend beyond the PSP population. …”
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