Mostrando 861 - 880 Resultados de 147,287 Para Buscar '"translator"', tiempo de consulta: 0.45s Limitar resultados
  1. 861
    por LeBrasseur, Nathan
    Publicado 2019
    “…The therapeutic potential of senolytic interventions to improve health- and lifespan has been supported by translational research studies, including murine models of aging, atherosclerosis, osteoporosis, neurodegeneration, pulmonary fibrosis, and frailty. …”
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  2. 862
  3. 863
  4. 864
  5. 865
    “…The aim of this study was to translate the “orientation” query of the ADAS-Cog inventory to rats and to investigate whether they can determine which time of the day they are. …”
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  6. 866
  7. 867
    por Inada, Toshifumi
    Publicado 2020
    “…Aberrant translation leads to activation of one of several quality control pathways depending on the nature of the problem. …”
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  8. 868
    “…Techniques to engineer each component of the translation machinery are covered in turn, including transfer RNAs, translation factors, and the ribosome. …”
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  9. 869
    “…Particularly at the translational level, regulation is controlled by a variety of RNA binding proteins, translation and associated factors, numerous enzymes, and by post-translational modifications (PTM). …”
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  10. 870
    “…Therefore, we explore how the expression of NRXN2α, one of encoding genes for neurexins, is regulated at the translational level. NRXN2α transcript has a long and conserved 5′-untranslated region (5′UTR) suggestive of the rapid regulation of protein expression at the translational level. …”
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  11. 871
  12. 872
    “…Estimates indicate ~70% of all eukaryotic proteins are modified by at least one type of glycosylation, while nearly 20% of all proteins are known to be lipid-modified. Protein post-translational modification (PTM) by glycosylation and lipidation rely on the spatiotemporal colocalization of enzyme, substrate, and glycan or lipid donor molecule and do not require an upstream “blueprint” or specialized processing machinery for synthesis. …”
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  13. 873
    “…Therefore, these observations emphasize the importance of translational control in stem cell homeostasis and fate decisions. …”
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  14. 874
  15. 875
    “…Distinct roadblocks prevent translating basic findings in viral pathogenesis into therapies and implementing potential solutions in the clinic. …”
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  16. 876
    por Triendl, Robert
    Publicado 2004
    “…Over the past few decades, Japanese immunologists have been involved in many important discoveries at the forefront of immunological research, yet, when it comes to the translation of new discoveries into clinical innovations and new therapies, Japan's track record seems more modest.…”
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  17. 877
    “…Although there is overwhelming pressure from funding agencies and the general public for scientists to bridge basic and translational studies, the fact remains that there are significant hurdles to overcome in order to achieve this goal. …”
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  18. 878
    “…Here, we discuss the relative contribution of individual components of the translational apparatus (e.g. tRNAs, elongation factors and their modifiers) to the overall control of translation elongation and how their dysregulation contributes towards disease processes.…”
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  19. 879
    por Mohr, Ian, Sonenberg, Nahum
    Publicado 2012
    “…By controlling gene expression at the level of mRNA translation, organisms temporally and spatially respond swiftly to an ever-changing array of environmental conditions. …”
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  20. 880
    “…Translational control plays a central role in regulation of gene expression and can lead to significant divergence between mRNA- and protein-abundance. …”
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