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  1. 1001
    “…Our data demonstrate that ATXN2 RAN translation is weak compared to AUG translation and is dependent on ATXN2 sequences flanking the CAG repeat.…”
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    Repeat Associated Non-AUG Translation (RAN Translation) Dependent on Sequence Downstream of the ATXN2 CAG Repeat
  2. 1002
    “…In mouse embryonal fibroblasts, ATXN2 absence also enhanced phosphorylation of the ribosomal protein S6 during growth stimulation, while impairing the rate of overall protein synthesis rates, suggesting a block between the enhanced translation drive and the impaired execution. Thus, the physiological role of ATXN2 subtly modifies the abundance of cellular translation factors as well as global translation. …”
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    Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate
  3. 1003
    “…Advancements in the scientific knowledge of stem cell biology, along with highly encouraging preclinical proof-of-concept studies, in the last several years have served as a launch pad for testing such therapeutics in humans with life-threatening diseases. However, translating basic research findings into human therapy has not been straightforward and has presented many scientific, clinical, and regulatory challenges for scientists and clinicians. …”
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    Translating stem cell research to the clinic: a primer on translational considerations for your first stem cell protocol
  4. 1004
    “…Interestingly, many mRNAs localized to protrusions are translationally repressed. Specific cis-regulatory elements within mRNA UTRs define whether mRNAs are locally translated or repressed. …”
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    Global Analysis of mRNA, Translation, and Protein Localization: Local Translation Is a Key Regulator of Cell Protrusions
  5. 1005
    por Devine, Helen, Patani, Rickie
    Publicado 2016
    “…This review will focus on the translational potential of hiPSCs in clinical neurology and the importance of integrating this approach with complementary model systems to increase the translational yield of preclinical testing for the benefit of patients. …”
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    The translational potential of human induced pluripotent stem cells for clinical neurology: The translational potential of hiPSCs in neurology
  6. 1006
    “…Conversely, the synthesis and co-translational insertion of such proteins into the thylakoid membrane have been suggested to be influenced by chlorophyll availability. …”
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    Translation and Co-translational Membrane Engagement of Plastid-encoded Chlorophyll-binding Proteins Are Not Influenced by Chlorophyll Availability in Maize
  7. 1007
    “…We report the development of the Translational Science Benefits Model (TSBM), a framework designed to support institutional assessment of clinical and translational research outcomes to measure clinical and community health impacts beyond bibliometric measures. …”
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    The Translational Science Benefits Model: A New Framework for Assessing the Health and Societal Benefits of Clinical and Translational Sciences
  8. 1008
    “…Several families of plant viruses evolved cap-independent translation enhancers (3′CITE) in the 3′ untranslated regions of their genomic (g)RNAs to compete with ongoing cap-dependent translation of cellular mRNAs. …”
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    Concerted action of two 3′ cap-independent translation enhancers increases the competitive strength of translated viral genomes
  9. 1009
    por Kothari, Anita, Sibbald, Shannon L.
    Publicado 2017
    “…Putting health theories, research and knowledge into practice is a challenge referred to as the knowledge-toaction gap. Knowledge translation (KT), and its related concepts of knowledge mobilization, implementation science and research impact, emerged to mitigate this gap. …”
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    Using Complexity to Simplify Knowledge Translation: Comment on "Using Complexity and Network Concepts to Inform Healthcare Knowledge Translation"
  10. 1010
    “…In this case, protein synthesis directs translation of specific mRNAs, and, in turn, promotes cell survival, invasion, angiogenesis, and metastasis of tumors. …”
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    Eukaryotic translation initiation factor 6 overexpression plays a major role in the translational control of gallbladder cancer
  11. 1011
    “…In contrast, P. falciparum translational machinery can efficiently and accurately translate polyA tracks without activating mRNA surveillance pathways. …”
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    Adaptation of Translational Machinery in Malaria Parasites to Accommodate Translation of Poly-Adenosine Stretches Throughout Its Life Cycle
  12. 1012
    “…The quality of human translation was long thought to be unattainable for computer translation systems. …”
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    Transforming machine translation: a deep learning system reaches news translation quality comparable to human professionals
  13. 1013
    “…The impact of post-translational modifications of hnRNP A1 on HIV-1, HTLV-1 and MMTV IRES activity was also assessed. …”
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    Post-translational modifications of hnRNP A1 differentially modulate retroviral IRES-mediated translation initiation
  14. 1014
    “…mRNA secondary structure influences translation. Proteins that modulate the mRNA secondary structure around the translation initiation region may regulate translation in plastids. …”
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    Light-Dependent Translation Change of Arabidopsis psbA Correlates with RNA Structure Alterations at the Translation Initiation Region
  15. 1015
    “…To control accidental UPR activation, multiple fail-safe mechanisms have been proposed to prevent leaky HAC1 splicing and translation and to facilitate rapid degradation of translated Hac1(u)p and Hac1(i)p. …”
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    Does Saccharomyces cerevisiae Require Specific Post-Translational Silencing against Leaky Translation of Hac1up?
  16. 1016
    “…Signal recognition particle (SRP) is critical for delivering co-translational proteins to the bacterial inner membrane. …”
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    Compensating Complete Loss of Signal Recognition Particle During Co-translational Protein Targeting by the Translation Speed and Accuracy
  17. 1017
    “…We also summarize the fine-tuned regulation of translation initiation by various trans-acting factors through cis-elements on mRNAs.…”
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    Translation Initiation Regulated by RNA-Binding Protein in Mammals: The Modulation of Translation Initiation Complex by Trans-Acting Factors
  18. 1018
    “…Whether translation elongation process can feedback to regulate initiation efficiency is unclear. …”
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    Codon usage and protein length-dependent feedback from translation elongation regulates translation initiation and elongation speed
  19. 1019
    por Chu, Duan, Wei, Lai
    Publicado 2019
    “…CONCLUSIONS: HeLa cells compensate for genes unfavorable for translation by m(6)A modification and enhance their translation efficiency. …”
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    Human cancer cells compensate the genes unfavorable for translation by N(6)-methyladenosine modification and enhance their translation efficiency
  20. 1020
    “…Translational regulation was investigated at the genome-scale in Escherichia coli cells. …”
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    Synergistic Regulation of Transcription and Translation in Escherichia coli Revealed by Codirectional Increases in mRNA Concentration and Translation Efficiency
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