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1021“…Deregulation of mRNA translation is a frequent feature of cancer. Eukaryotic translation initiation factor 3 subunit B (EIF3B) has been reported as an oncogene; however, its role in HNSCC has yet to be fully elucidated. …”
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1022por Ulicna, Livia, Kimmey, Samuel C., Weber, Christopher M., Allard, Grace M., Wang, Aihui, Bui, Nam Q., Bendall, Sean C., Crabtree, Gerald R., Bean, Gregory R., Van Rechem, Capucine“…Furthermore, mSWI/SNF subunits were present in the cytoplasm and interacted with the translation initiation machinery, and short-term inhibition and depletion of specific subunits decreased global translation, implicating a direct role for these factors in translation. …”
Publicado 2022
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1023“…This study explores the emotional impact of contextually-relevant source texts (STs) and their influence on student translators' behavior. During the first weeks of the Spanish COVID-19 lockdown, an experimental study was carried out in which 69 Spanish translation students were instructed to translate two English STs with different evaluative attitudes (i.e. optimistic vs. pessimistic) toward the COVID-19 crisis. …”
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1024por Zhang, Li-Yong, Xing, Tao, Du, Li-Xin, Li, Qing-Min, Liu, Wei-Dong, Wang, Ji-Yue, Cai, Jing“…In this study, a molecular translator was employed to convert the input protein to output deoxyribonucleic acid signal, which was further amplified by ISDPR. …”
Publicado 2015
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1025por Valencia, Alejandro, Stillwell, Lisa, Appold, Stephen, Arunachalam, Saravanan, Cox, Steven, Xu, Hao, Schmitt, Charles P., Schurman, Shepherd H., Garantziotis, Stavros, Xue, William, Ahalt, Stanley C., Fecho, KaramarieEnlace del recurso
Publicado 2020
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1026por Magazinnik, Tanya, Anand, Monika, Sattlegger, Evelyn, Hinnebusch, Alan G., Kinzy, Terri Goss“…Genetic screens in Saccharomyces cerevisiae have identified the roles of ribosome components, tRNAs and translation factors in translational fidelity. These screens rely on the suppression of altered start codons, nonsense codons or frameshift mutations in genes involved in amino acid or nucleotide metabolism. …”
Publicado 2005
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1027por Kho, Michelle E, Estey, Elizabeth A, DeForge, Ryan T, Mak, Leanne, Bell, Brandi L“…BACKGROUND: Funding the education and training of the next generation of health researchers is a key mandate of the Canadian Institutes of Health Research (CIHR) knowledge translation (KT) portfolio. The field of KT is growing daily; thus, the training and development of a new generation of KT researchers is essential. …”
Publicado 2009
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1028“…The underlying circadian mechanism appears to comprise two subcomponents: a post-translational oscillator (PTO) and a transcriptional/translational feedback loop (TTFL). …”
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1029“…Two such non-translation initiation codon (AUG)-initiated upstream open reading frames (uORFs) (nAuORFs 1 and 2) occur in GCN4 mRNA upstream of the four AUG-initiated uORFs (uORFs 1–4) that regulate GCN4 translation. …”
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1030por Martínez-Silva, Ana Valeria, Aguirre-Martínez, César, Flores-Tinoco, Carlos E., Alejandri-Ramírez, Naholi D., Dinkova, Tzvetanka D.“…One of the most regulated steps of translation initiation is the recruitment of mRNA by the translation machinery. …”
Publicado 2012
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1031“…We report studies on the basic translation process of tobacco psbD-psbC mRNAs using an in vitro translation system from tobacco chloroplasts. …”
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1032“…The mRNAs encoding poly (A) binding protein (PABP1), eukaryotic elongation factor 1A (eEF1A) and ribosomal protein S6 (RPS6) belong to the family of terminal oligo pyrimidine tract (TOP) containing mRNAs. Translation of the TOP mRNAs is regulated by growth signals and usually codes for proteins involved in mRNA translation. …”
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1033por Vera, Maria, Pani, Bibhusita, Griffiths, Lowri A, Muchardt, Christian, Abbott, Catherine M, Singer, Robert H, Nudler, Evgeny“…Translation elongation factor eEF1A has a well-defined role in protein synthesis. …”
Publicado 2014
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1034por Jones, Grant D, Williams, Ernest P, Place, Allen R, Jagus, Rosemary, Bachvaroff, Tsvetan R“…BACKGROUND: Dinoflagellates are eukaryotes with unusual cell biology and appear to rely on translational rather than transcriptional control of gene expression. …”
Publicado 2015
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1035por Halaby, Marie-Jo, Li, Yan, Harris, Benjamin R., Jiang, Shuxia, Miskimins, W. Keith, Cleary, Margot P., Yang, Da-Qing“…However, the mechanism underlying IRES-mediated p53 translation in response to DNA damage is still poorly understood. …”
Publicado 2015
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1036por Tang, Hao, Fan, Xiuqin, Xing, Junyue, Liu, Zhenyun, Jiang, Bin, Dou, Yali, Gorospe, Myriam, Wang, Wengong“…NSun2 methylated the 5′-untranslated region (UTR) of p27 mRNA at cytosine C64 in vitro and in cells, thereby repressing the translation of p27. During replicative senescence, increased p27 protein levels were accompanied by decreased NSun2 protein levels. …”
Publicado 2015
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1037por Nissley, Daniel A., Sharma, Ajeet K., Ahmed, Nabeel, Friedrich, Ulrike A., Kramer, Günter, Bukau, Bernd, O'Brien, Edward P.“…The rates at which domains fold and codons are translated are important factors in determining whether a nascent protein will co-translationally fold and function or misfold and malfunction. …”
Publicado 2016
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1039por Li, Zengxia, Cheng, Zhao, Raghothama, Chaerkady, Cui, Zhaomeng, Liu, Kaiyu, Li, Xiaojing, Jiang, Chenxiao, Jiang, Wei, Tan, Minjia, Ni, Xiaohua, Pandey, Akhilesh, Liu, Jun O, Dang, Yongjun“…Controlling translation initiation is an efficient way to regulate gene expression at the post-transcriptional level. …”
Publicado 2018
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1040por Adamo, Sergio“…This first 2018 Issue of the European Journal of Translational Myology presents many novelties, that are demonstrating that the journal is vital and expanding its authorship, readership and relevance from focused fields of biology, physiology, diagnostic, management and rehabilitation of skeletal muscle tissue to the more interesting and clinical relevant fields of human mobility up to those of general medicine. …”
Publicado 2018
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