Mostrando 1,181 - 1,200 Resultados de 147,287 Para Buscar '"translator"', tiempo de consulta: 0.43s Limitar resultados
  1. 1181
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  6. 1186
    “…To encourage more cell biologists to venture into the realm of translational research on a regular basis, we would like to share a handful of the many lessons that we have learned in our effort to develop experimental treatments for Hutchinson-Gilford progeria syndrome (HGPS), an endeavor that many view as a “poster child” for how basic cell biology can be translated to the clinic.…”
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  7. 1187
    “…Generally, autophagy and translation are inversely regulated. Many kinds of stress lead to attenuation of translation via phosphorylation of eukaryotic translation initiation factor alpha (eIF2α). …”
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  8. 1188
  9. 1189
    “…Here we integrate previously orthogonal lines of inquiry involving stakeholder research to describe the translational landscape as well as challenges on its horizon.…”
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  10. 1190
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  13. 1193
    por Seibt, Julie, Frank, Marcos G.
    Publicado 2012
    “…We demonstrate that activation of the mammalian target of rapamycin [mTOR] pathway, an important regulator of translation initiation,(4) is necessary for sleep-dependent ODP consolidation and that sleep promotes translation (but not transcription) of proteins essential for synaptic plasticity (i.e., ARC and BDNF). …”
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  14. 1194
    por Crawley, Jacqueline N.
    Publicado 2012
    “…Based on the strong genetic evidence, mice with targeted mutations in homologous genes have been generated as translational research tools. Mouse models of autism have revealed behavioral and biological outcomes of mutations in risk genes. …”
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  15. 1195
    por Ran, Wenqi, Higgs, Paul G.
    Publicado 2012
    “…There is also considerable evidence that codon usage is influenced by accuracy of translation, and some authors have argued that accuracy is more important than speed. …”
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  16. 1196
    “…The introduction of novel agents such as the proteasome inhibitor bortezomib and the immunomodulatory drugs thalidomide and lenalidomide, which were rapidly translated from preclinical studies at the Dana-Farber Cancer Institute into clinical trials, has changed the treatment paradigm and markedly extended overall survival; MM has therefore become a remarkable example of translational cancer research in new drug development. …”
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  17. 1197
    por Brahmachari, Samir K
    Publicado 2012
    “…The aim of the Medical bioinformatics section is to aid the development and maturation of the field by providing a platform for the translation of these datasets into useful clinical applications. …”
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  18. 1198
    por Cheng, Xiwen, Kao, Hung-Ying
    Publicado 2013
    “…In this review, we discuss the fast-moving horizon of post-translational modifications targeting PML.…”
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  19. 1199
    por Szostak, Emilia, Gebauer, Fátima
    Publicado 2013
    “…Critical for translational control are the trans-acting factors, RNA-binding proteins (RBPs) and small RNAs that bind to the mRNA and modify its translatability. …”
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  20. 1200
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