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1361por Zeugfang, Daniel, Wisetborisut, Anawat, Angkurawaranon, Chaisiri, Aramrattana, Apinun, Wensing, Michel, Szecsenyi, Joachim, Krug, KatjaEnlace del recurso
Publicado 2018
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1362“…The clinical phenotypes are usually early-onset, severe, and often fatal, implying the importance of mitochondrial translation from birth. However, some rare, reversible infantile mitochondrial diseases are caused by very specific defects of mitochondrial translation. …”
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1363
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1364por EBioMedicineEnlace del recurso
Publicado 2018
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1365
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1366“…Here we review these strategies and their implications for successful translation of biomarkers to clinical practice. We believe that the identification of blood protein panels for the identification of disease phenotypes is now a reproducible and standard (albeit complex) process.…”
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1367“…We also consider the role of leaderless translation in the ability of M. tuberculosis to establish latent infection and look at the experimental evidence that translational regulatory mechanisms operate in mycobacteria during stress adaptation, particularly focussing on differences in toxin-antitoxin systems between E. coli and M. tuberculosis and on the role of tuneable translational fidelity in conferring phenotypic antibiotic resistance. …”
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1368por Mann, Douglas L.Enlace del recurso
Publicado 2016
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1369
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1370“…In order to improve trainees’ written communication skills, we tested an exercise that involved generating a revised article describing prior research, in essence “translating” the science into basic language. Following the guidelines set out by “Frontiers for Young Minds” and feedback received from “Young Reviewers”, we wrote a revised article with a simpler description of the research. …”
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1371“…Post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, SUMOylation, etc., of proteins can modulate protein properties such as intracellular distribution, activity, stability, aggregation, and interactions. …”
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1373por Foty, Richard G., Gibbs, Elizabeth M., Lips, Esther H., Menon, Madhvi, Hafler, Janet P.“…Translational Medicine (TM) is a comparatively new field of study that focusses on the continuum of activities from the conception of an idea, to advanced clinical testing and the development of a new medical technology or drug. …”
Publicado 2018
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1374“…The fifth in a 5-part series on the clinical and translational sciences educational pipeline, this paper focuses on strategies for developing leadership capacity among senior faculty and administrators responsible for clinical and translational science (CTS) research. …”
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1375por Cornelissen, Bart, Knight, James C., Mukherjee, Somnath, Evangelista, Laura, Xavier, Catarina, Caobelli, Federico, Del Vecchio, Silvana, Rbah-Vidal, Latifa, Barbet, Jacques, de Jong, Marion, van Leeuwen, Fijs W. B.Enlace del recurso
Publicado 2018
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1376“…Here, we provide key examples to help understand how mutations present in genes can affect translational output.…”
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1377por Estape, Estela S., Quarshie, Alexander, Segarra, Barbara, Martin, María San, Ríos, Ruth, Martínez, Karen, Ali, Jacquelyn, Nwagwu, Ulochi, Ofili, Elizabeth, Pemu, Priscilla“…A Hispanic public, academic health center, and a historically black private medical school, have joined efforts in this article to share their experiences in addressing diversity in the clinical and translational research workforce with grant support from the National Institutes of Health. …”
Publicado 2018
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1378
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1379“…Autoimmunity treatments, fruitfully pioneered in mouse models, can be disappointing or result in immunosuppression and opportunistic infections in translational trials. Many possible reasons exist, but one major, overlooked reason may be the treatment timing in relation to circadian oscillations of the immune system. …”
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1380por André, Sabine, Kaltner, Herbert, Manning, Joachim C., Murphy, Paul V., Gabius, Hans-JoachimEnlace del recurso
Publicado 2015
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