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  1. 143981
    por Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, deMonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K, Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, vanRee, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, deJong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Ömer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, ErvinÇ, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Alves, Rodrigo Rodrigues, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F, Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, Akdis, Cezmi A
    Publicado 2012
    “…The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. …”
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    Research needs in allergy: an EAACI position paper, in collaboration with EFA
  2. 143982
    “…PURPOSE: This study defined the time course of changes in Hb(mass), [Image: see text] O(2 max) as well as running time trial performance following 4 weeks of rHuEpo administration to determine whether the laboratory observations would translate into actual improvements in running performance in the field. …”
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    Haemoglobin Mass and Running Time Trial Performance after Recombinant Human Erythropoietin Administration in Trained Men
  3. 143983
    “…More research is needed to determine whether the long-term effectiveness of these programs is sustainable among larger, more diverse samples of chronically ill patients. The effective translation of new knowledge, social technologies, and engagement techniques will likely result in novel approaches for empowering, engaging, and educating older adults with chronic disease.…”
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    Web 2.0 Chronic Disease Self-Management for Older Adults: A Systematic Review
  4. 143984
    “…At study planning, exploratory translational research objectives were 1) to assess the predictive value of circulating tumor cells for disease-free survival, 2) to examine the predictive value of single nucleotide polymorphisms for disease-free survival with respect to genes related either to toxicity or to drug targets, 3) to assess genomic rearrangements associated with response or resistance to FOLFOX treatment, 4) to identify an immunologic signature associated with metabolic tumor response to FOLFOX therapy and, finally, 5) to create a bank of frozen tumor samples for future studies. …”
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    Preoperative chemosensitivity testing as Predictor of Treatment benefit in Adjuvant stage III colon cancer (PePiTA): Protocol of a prospective BGDO (Belgian Group for Digestive Oncology) multicentric study
  5. 143985
    “…NVP-BGT226 as well as NVP-BEZ235 profoundly and globally suppress AKT signaling pathways, which translates into potent antiproliferative effects. Furthermore, NVP-BGT226 has potent proapoptotic effects in vitro as well as in ex vivo native blasts. …”
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    Cell cycle-dependent activity of the novel dual PI3K-MTORC1/2 inhibitor NVP-BGT226 in acute leukemia
  6. 143986
    “…RESULTS: Cathinone, cathine and norephedrine generally reduced post-translational modifications of intracellular signal transducers in T-lymphocytes, B-lymphocytes, natural killer cells and monocytes, most prominently affecting c-Cbl (pTyr700), ERK1/2 (p-Thr202/p-Tyr204), p38 MAPK (p-Thr180/p-Tyr182) and p53 (both total p53 protein and p-Ser15). …”
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    Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine
  7. 143987
    “…Furthermore, the increased stability of our new macrobicyclic (64)Cu-CB-TE2A-PA-AE105 PET ligand is paralleled by an excellent imaging contrast during non-invasive PET scanning of uPAR expression in preclinical mouse cancer models. The translational promises displayed by this PET-tracer for future clinical cancer patient management remains, however, to be investigated.…”
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    Improved PET Imaging of uPAR Expression Using new (64)Cu-labeled Cross-Bridged Peptide Ligands: Comparative in vitro and in vivo Studies
  8. 143988
    “…METHODS/DESIGN: The STRIDE study is a multi-site, parallel, two-arm randomized controlled translational trial. Participants were recruited from community mental health clinics and an integrated not-for-profit health system. …”
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    STRIDE: a randomized trial of a lifestyle intervention to promote weight loss among individuals taking antipsychotic medications
  9. 143989
    “…RESULTS: We first confirmed that RNAi-induced knock-down of the ITGA6 gene was successful, at both transcription and translational levels, with a significant decrease in the membrane expression of CD49f, apart from CD49b, CD49c and CD49d, ascertained by cytofluorometry on living TEC. …”
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    ITGA6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cells
  10. 143990
    “…The rapid rise in their use has created the need for a systematic synthesis of the evidence of their impact as knowledge translation (KT) tools in the health care sector and for an inventory of the factors that affect their use. …”
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    Wikis and Collaborative Writing Applications in Health Care: A Scoping Review
  11. 143991
    “…Dopamine transporter mutants also showed diminished dopamine binding affinity, reduced cell surface transporter, loss of post-translational dopamine transporter glycosylation and failure of amphetamine-mediated dopamine efflux. …”
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    Dopamine transporter deficiency syndrome: phenotypic spectrum from infancy to adulthood
  12. 143992
    por Naveršnik, Klemen, Mrhar, Aleš
    Publicado 2014
    “…Routine efficacy data can be used as the input to the cost-effectiveness model, which employs a mapping function to translate a depression specific score into quality-adjusted life-years. …”
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    Routine Real-Time Cost-Effectiveness Monitoring of a Web-Based Depression Intervention: A Risk-Sharing Proposal
  13. 143993
    “…Evidence is provided that C14 acts through light-dependent (mRNA photocleavage) and light-independent (translation inhibition) mechanisms.…”
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    Anticancer activity of cationic porphyrins in melanoma tumour-bearing mice and mechanistic in vitro studies
  14. 143994
    “…RESULTS: Experiences of participants related to the following themes: (1) creating a development team, (2) expectations regarding responsibilities and roles, (3) translating user requirements into technical requirements, (4) technical challenges, (5) evaluation of developed products and services, and (6) valorization. …”
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    Experiences of Multidisciplinary Development Team Members During User-Centered Design of Telecare Products and Services: A Qualitative Study
  15. 143995
    “…A combined strategy of anti-PD-1/GITR mAb plus cisplatin or paclitaxel should be considered translation into clinic.…”
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    Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs
  16. 143996
    “…Subsequently, demographic and qualitative data was collected using a questionnaire and an in-person interview conducted in Spanish, then translated into English. The qualitative questions captured data on 4 categories: comfort, acceptability, preference, and accuracy. …”
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    User Perceptions of an mHealth Medicine Dosing Tool for Community Health Workers
  17. 143997
    “…OBJECTIVE: The Propofol cardioplegia for Myocardial Protection Trial (ProMPT) aims to translate the successful animal intervention to the human clinical setting. …”
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    The Effects of Propofol Cardioplegia on Blood and Myocardial Biomarkers of Stress and Injury in Patients With Isolated Coronary Artery Bypass Grafting or Aortic Valve Replacement Using Cardiopulmonary Bypass: Protocol for a Single-Center Randomized Controlled Trial
  18. 143998
    “…Influenza transcription results in spliced mRNAs (M2 and NS2), intron-containing mRNAs (M1 and NS1), and intron-less mRNAs (HA, NA, NP, PB1, PB2, and PA), all of which undergo nuclear export into the cytoplasm for translation. Most cellular mRNA nuclear export is Nxf1-mediated, while select mRNAs utilize Crm1. …”
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    Influenza polymerase encoding mRNAs utilize atypical mRNA nuclear export
  19. 143999
    “…Both vif and vpr mRNAs harbor their translational start codons within the intron bordering the non-coding leader exons 2 and 3, respectively. …”
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    A functional conserved intronic G run in HIV-1 intron 3 is critical to counteract APOBEC3G-mediated host restriction
  20. 144000
    “…ALDH positive MECs were sorted and used for transcriptional and translational analysis for genes and microRNAs. In silico analysis for target prediction and networking was performed through online portals of Target Scan and Metacore. …”
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    microRNA alterations in ALDH positive mammary epithelial cells: a crucial contributing factor towards breast cancer risk reduction in case of early pregnancy
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