“…We also use our proteomics pipeline to identify an extensive range of post-translationally modified proteins in RA and SLE, including histones and granule proteins, many of which are known targets of auto-antibodies in each disease.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In medicine today, there are deficiencies in the application of knowledge translation (KT) in clinical practice. Some medical procedures are not required, and therefore, no value is added to the patient’s care. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Altogether, these translational findings indicate that the vascular endothelium plays a key physiologic role during the early events of perivascular decidualization in the human endometrium. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Further studies will assess the translatability of these findings into clinical settings.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Data were transcribed, translated from Shona into English, coded and thematically analysed using NVivo software. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…AD-01 was effective at reducing triple negative MDA-MB-231 breast cancer cell migration (n ≥ 3, p < 0.05) and invasion (n ≥ 3, p < 0.001) and this was translated in vivo where AD-01 inhibited breast cancer metastasis in MDA-MB-231-lucD3H1 in vivo model (p < 0.05). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We applied cell depletion and adoptive transfer strategies using lymphocyte-deficient Rag1 knockout mice; DEREG mice, which express a diphtheria toxin receptor–enhanced green fluorescent protein fusion protein under the control of the promoter/enhancer region of the regulatory T (T(reg)) cell–restricted Foxp3 transcription factor; and dendritic cell-depleted CD11c-Cre iDTR mice. Translational potential was explored in a porcine model of reperfused MI using serial contrast-enhanced magnetic resonance imaging. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Since the nanoparticles are well defined virus-like particles and the micron-sized adjuvant MCT has been used for decades in allergen-specific desensitization, this approach may readily be translated to the clinic. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40425-019-0587-z) contains supplementary material, which is available to authorized users.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Among the various RNA regulatory machineries, nonsense-mediated mRNA decay (NMD) is a stress responsive cellular surveillance system that degrades selected mRNA substrates to prevent the translation of defective or harmful proteins. Whether this pathway is affected in neurodegenerative diseases is unclear. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: The picornaviral 3C protease mediates viral polyprotein maturation and multiple cleavages of host proteins to modulate viral translation and transcription. The 3C protease has been regarded as a valid target due to its structural similarity among different picornaviruses and minimal sequence similarity with host proteins; therefore, the development of potent inhibitors against the 3C protease as an antiviral drug is ongoing. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Translating evidence-based interventions from study conditions to actual practice necessarily requires adaptation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…There are some clinical prediction rules that may help to stratify patients with eCOPD by their risk of poor evolution or adverse events. The translation of these clinical prediction rules into computer applications would allow their implementation in clinical practice. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our findings increase the confidence in the ability to translate preclinical PK of TPPU in rats to humans and facilitates the potential clinical development of TPPU and other sEH inhibitors.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…ALS-increased DEGs had high exosome expression, were neutrophil-specific, associated with translation, and overlapped significantly with genes near ALS susceptibility loci (e.g., IFRD1, TBK1, CREB5). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Notably, control Cacna1d-eGFP(flex/-) IHCs showed a significant reduction in Ca(v)1.3 channel cluster sizes and currents, suggesting that the intronic construct interfered with gene translation or splicing. These pitfalls are likely to be a frequent problem of many genetically modified mice with complex or multiple gene-targeting constructs or fluorescent proteins. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: The mRNA expression-to-secretion correlation (SeCEP) pinpointed multiple genes that are fully translated into the oncogenically active secretome in a PAM50-subtypic manner. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Studies making efforts to further elucidate the protective mechanisms and to benefit the translational application are of great value.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Finally, GO and GSEA analysis showed that the elevated expression of eIF3i was significantly correlated with the biological processes of cell proliferation, mRNA processing, translation, T cell receptor signaling, NF-κB signaling and others. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Ongoing monitoring and research is required to confirm the biochemical response translates to the expected subsequent impact on skeletal and non-skeletal outcomes, including linear growth and deformities. …”
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: Rotavirus antigenemia and RNAemia occur in a significant number of children hospitalised for acute gastroenteritis in Belém, Brazil, and may contribute to a greater disease severity, particularly translated into a greater number of vomiting episodes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso