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  1. 144321
    “…BACKGROUND: MicroRNAs (miRNAs) play a role in regulating osteogenic differentiation (OD) of mesenchymal stem cells by inhibiting mRNAs translation under cyclic strain. miR-503-3p was downregulated in OD of human adipose-derived stem cells (hASCs) in vivo under cyclic strain in our previous study, while it might target the Wnt/β-catenin (W-β) pathway. …”
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    MicroRNA-503-3p affects osteogenic differentiation of human adipose-derived stem cells by regulation of Wnt2 and Wnt7b under cyclic strain
  2. 144322
    “…Further clinical studies are required to determine whether these findings translate into differences in clinical outcome. CLINICAL RELEVANCE: All-inside ACLR is gaining popularity in hamstring ACL reconstructive techniques. …”
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    Biomechanical Comparison of Graft Preparation Techniques for All-Inside Anterior Cruciate Ligament Reconstruction
  3. 144323
    “…METHODS: To investigate whether genetic variants identified in the CYP2E1 coding region affect enzyme function, the enzymes of four single nucleotide polymorphism (SNP) variants in the coding region (novel c.1009C>T, causing p.Arg337X, where X represents the translational stop codon; c.227G>A, causing p.Arg76His; c.517G>A, yielding p.Gly173Ser; and c.1263C>T, presenting the highest allele frequency), two novel alleles (c.[227G>A;1263C>T] and c.[517G>A;1263C>T]), and the wild-type CYP2E1 were heterologously expressed in COS-7 cells and functionally characterized in terms of expression level and chlorzoxazone 6-hydroxylation activity. …”
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    Functional characterization of the chlorzoxazone 6-hydroxylation activity of human cytochrome P450 2E1 allelic variants in Han Chinese
  4. 144324
    “…CONCLUSION: Females demonstrated greater quadriceps strength deficits than males at 6 months post-ACLR with hamstring autograft, which may translate into greater functional hop testing deficits. …”
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    Recovery Following ACL Reconstruction in Male vs. Female Adolescents: A Matched, Sex-Based Cohort Analysis of 543 Patients
  5. 144325
    “…Under scenario #5, approximately 31,687 incident disease cases and 59,068 deaths could be prevented among males over a 10-year projection period, as well as 59,173 incident disease cases and 121,689 deaths among females. This translates to 14.4 and 22.2% of the prevented diseases cases among males and females under scenario #6, and 13.7 and 27.7% of the prevented deaths under scenario #6. …”
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    Equity impacts of interventions to increase physical activity among older adults: a quantitative health impact assessment
  6. 144326
    “…The mean patellar laxity index and lateral patellar translation assessed with stress radiography were measured preoperatively and postoperatively to quantify MPFL laxity. …”
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    Preoperative Complete Patellofemoral Dislocation in Extension Predicts an Inferior Clinical Outcome After Medial Patellofemoral Ligament Reconstruction in Patients With Recurrent Patellar Dislocation
  7. 144327
    “…Future research should clarify how increased quit attempts as a consequence of Stoptober translate into quit success and which of Stoptober’s ingredients were most important in increasing quit attempts, especially among vulnerable groups.…”
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    Impact of the “Stoptober” Smoking Cessation Campaign in England From 2012 to 2017: A Quasiexperimental Repeat Cross-Sectional Study
  8. 144328
    “…Sensitivity, positive predictive value, and accuracy of the classical blue dye technique and of the investigatory fluorescence imaging technique will be calculated. Translational research will be proposed, if applicable. …”
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    Systemic Sentinel Lymph Node Detection Using Fluorescence Imaging After Indocyanine Green Intravenous Injection in Colorectal Cancer: Protocol for a Feasibility Study
  9. 144329
    por Hemingway, H, Lyons, R, Li, Q, Buchan, I, Ainsworth, J, Pell, J, Morris, A, Barnes, Michael R, Bedford, Helen, Bennie, Marion, Blandford, Ann, Briggs, Andy, Brocklehurst, Peter, Brophy, Sinead, Brown, Gavin, Burton, Paul, Burton, Paul, Butler, Christopher, Capewell, Simon, Carpenter, James, Carroll, John, Cassell, Jackie A., Castillo, Fortunato, Catchpole, Mike, Caulfield, Mark, Colhoun, Helen, Coveney, Peter, Cunningham-Burley, Sarah, Custovic, Adnan, Deanfield, John, Denaxas, Spiros, Dennis, Michael, Dezateux, Carol, Dibben, Chris, Diggle, Peter, Dixon, Will, Dunn, Graham, El Emam, Khaled, Fone, David, Ford, David, Ford, Ian, Frank, John, Freemantle, Nick, Gabbe, Belinda, Gallacher, John, Gibson, Martin, Gilbert, Ruth, Gissler, Mika, Goble, Carol, Goldberg, Andy, Gravenor, Mike, Gunnell, David, Hannaford, Phil, Hayward, Andrew, Hickman, Matthew, Hingorani, Aroon, Holm, Soren, Holman, Cashel, John, Gareth, John, Ann, Jones, Kerina, Kalra, Dipak, Laurie, Graeme, Lewis, Shon, Lloyd, Keith, Lowe, Sarah, McCowan, Colin, Macleod, John, Martin, Richard M., Moore, Anthony (Tony), Moore, Laurence, Nazareth, Irwin, Nenadic, Goran, Paranjothy, Shantini, Parmar, Max, Pebody, Richard, Petersen, Steffen, Petersen, Irene, Pillay, Deenan, Preen, David, Pickett, Kate, Pritchard-Jones, Kathy, Przulj, Natasa, Renehan, Andrew, Roberts, Stephen, Robson, John, Rodgers, Sarah, Rossor, Martin, Russell, Ian, Shawe-Taylor, John, Sheikh, Aziz, Siebert, Stefan, Snooks, Helen, Sperrin, Matthew, Stephenson, Judith, Sullivan, Frank, Taylor, Chris, Taylor, Paul, Timmis, Adam, Ward, Hester J T, Williams, John, Williamson, Paula, Wilson, Alan, Wu, Olivia, Aitken, Mhairi, Akbari, Ashley, Al Sallakh, Mohammad, Al-Adely, Sarah, Alvarez-Madrazo, Samantha, Anne, Leslie, Aucott, Lorna, Bailey, Rowena, Balatsoukas, Panos, Bandyopadhyay, Amrita, Bartlett, Mike, Barutcu, Katherine, Batchelder, Catherine, Beales, Denise, Belmonte, Miguel, Blower, Brian, Brierley, Liam, Broadbent, Andrew, Burton, Paul, Castagnet, Mathilde, Cave, Daniel, Ceroni, Giovanna, Clemens, Tom, Collins, Huw, Conley, Ed, Costello, Carol-Ann, Couch, Phil, Cross, Lynsey, Cunningham, James, Daskalopoulou, Marina, Davies, Emma, Demmler, Joanne, Dixon, Emma, Dobbs, Christine, Dredge, Samuel, Drga, Vit, Evans, Hannah, Evans, Rachel, Farran, Bassam, Fitzpatrick, Natalie, Fleming, Michael, Fonferko-Shadrach, Beata, Fox, Sarah, Fry, Richard, Goddard, Catharine, Gonzalez-Izquierdo, Arturo, Gordon, Sharon, Green, Ben, Green, Benjamin, Gresham, Nick, Griffiths, Lucy, Griffiths, Rhiannon, Griffiths, Rowena, Haigh-Hutchinson, Kathy, Hainke, Melanie-Jayne, Hannaford, Phil, Hardy, Douglas, Harris, Steven, Hayes-Thompson, Nina, Heaven, Martin, Hillen, Neil, Holmes, Kate, Irvine, Elizabeth, Jackson, Guy, Jackson, Nadia, Jefferson, Emily, Jenkins, David, Johnson, Camille, Johnston, Jennifer, Katsoulis, Michail, Kirkwood, Daisy, Kunz, Holger, Kurz, Sabine, Lacey, Arron, Lamb, Amanda, Lea, Nathan, Lloyd, Stephen, Lyons, Jane, Machin, Matt, Malod-Dognin, Noel, Marryat, Louise, Martin, Cherry, McAllister, Gordon, McCleary, Nicola, McCloughan, Lucy, McIntosh, Paul, Melia, Stephen, Mizen, Amy, Mölter, Anna, Momo, Remi, Morgan, Alysha, Morrice, Lynn, Mortimer, Kate, Moayyeri, Alireza, Munro, Chris, Nangle, Clifford, Nind, Thomas, Norris, Ruth, North, Laura, O'Malley, Kieran, Owen, Rhydian, Panagiotopoulos, Adam, Papez, Vaclav, Papworth, Richard, Pasea, Laura, Pavis, Steve, Pell, Jill, Petschnigg, Julia, Porteous, Carol, Raza, Haider, Riordan, Emma, Robinson, Heather, Sethi, Nayha, Singh, Aneesha, Smith, Claire, Song, Jiao, Steiner, Markus, Stephenson, Paul, Tandon, Raj, Tempest, Ed, Thompson, Rachel, Toomey, Sarah, Torabi, Fatemeh, Tramma, Leandro, Tsang, Sandro, Tung, Wing-Chau, Turner, Sam, Turner, Victoria, Veer, Sabine Van Der, Vance, William, Walters, Angharad, Whiffen, Tony, Williams, Andrew James, Aldridge, Robert, Alvarez-Madrazo, Samantha, Anastasiou, Athanasios, Banerjee, Amitava, Berridge, Damon, Black, Corri, Burton, Paul, Colhoun, Helen, Cunningham-Burley, Sarah, Romero, Juan-Pablo Casas, Denaxas, Spiros, Dibben, Chris, Dobson, Richard, Fleming, Michael, Hardelid, Pia, Harron, Katie, Kunz, Holger, Martin, Glen, Moulton, Georgina, Mueller, Tanja, Peek, Niels, Nangle, Clifford, Sethi, Nayha, Shallcross, Laura, Sperrin, Matt, Taylor, Paul, van der Veer, Sabine, van Staa, Tjeerd, Watkins, Alan, Williamson, Elizabeth, Waheed, Adeel, Afzal, Nida, Ahmed, Harry, Al Sallakh, Mohammad Annas, Alhlayl, Adel, Allan, Victoria, Alzghaibi, Haitham, Appleby, Phil, Badrick, Ellie, Bailey, Kerry, Berry, Natalie, Bodegraven, Birgitta, Brierley, Helen, Brown, Benjamin, Ciminata, Giorgio, Cornish, Rosie, Cowan, Eilidh, Deliu, Mattea, Fitton, Catherine, Fleming, Michael, Haining, Kenny, Halliday, Kathryn, Horne, Elsie, Howard, Rebecca, Hulme, Will, Kremyda-Vlachou, Myrto, Marchant, Emily, Martin, Glen, Mueller, Tanja, Newman, Jenny, Peconi, Julie, Pham, Tra My, Reeves, Rachel, Rhodes, Daniel, Rudgard, William, Smith, Catherine, Spithourakis, Georgious, Valentine, Dennis Stallone, Wyper, Grant, Yassine, Bilal, Zylbersztejn, Anna, Aldridge, Robert, Azcoaga-Lorenzo, Amaya, Blackburn, Ruth, Brown, Ben, Caminati, Marco, Carragher, Raymond, Chung, Sheng-Chia, Dale, Caroline, Denaxas, Spiros, Edge, Chantal, Fatemifar, Ghazaleh, Fleming, Mike, George, Julie, Hale, Alison, Katsoulis, Michail, Harvey, William, Hassan, Lamiece, Lilaonitkul, Watjana, Lindner, Claudia, Luchenski, Serena, Lumbers, Tom, Niedzwiedz, Claire, Rafiq, Meena, Rannikmae, Kristiina, Shallcross, Laura, Keith, Smith, Strawbridge, Rona, Warren-Gash, Charlotte, Wu, Honghan, Ainsworth, John, Couch, Dr Philip, Ford, Professor David, Thompson, Simon, Pallas, Dr Jacky, Parsons, Professor Mark, Jefferson, Dr Emily, Cunnigham, Professor James, Moulton, Georgina, Anastasiou, Athanasios, Taylor, Professor Paul, Tung, Dr Wing-Chau, Goddard, Dr Catharine, McCowan, Professor Colin, Zhou, Dr Shang-Ming, Governance, Innovative, (Chair), Dr Kerina Jones, Laurie, Professor Graeme, Cunningham, Professor James, Lea, Dr Nathan, Hemingway, Harry, Evans, Ms Rachel, Ford, Professor David, Norris, Ms Ruth, Fitzpatrick, Ms Natalie, (Chair), Professor Sarah Cunningham-Burley, Aitken, Dr Mhairi, Carrigan, Dr Chris, Cross, Dr Lynsey, Denegri, Dr Simon, Fitzpatrick, Ms Natalie, Fox, Dr Sarah, Hassan, Dr Lamiece, Porteous, Ms Carol, Tully, Dr Mary, Buchan, Iain, Wyatt, Jeremy, Lyons, Ronan, Benzeval, Michaela, Delaney, Brendan, Sullivan, Frank, Morgan, Dr Alysha, Owen, Dr Rhydian, Beales, Dr Denise, Jackson, Ms Nadia, Kirkwood, Ms Daisy, Tung, Dr Wing-Chau, Goddard, Dr Catharine, McCloughan, Dr Lucy, Johnston, Ms Jennifer, Lamb, Dr Amanda, Norris, Ms Ruth, Turner, Ms Vicky
    Publicado 2020
    “…The Farr Institute helped define a central scientific challenge publishing a research corpus, demonstrating insights from electronic health record (EHR) and administrative data at each stage of the translational cycle in 593 papers with at least one Farr Institute author affiliation on PubMed. 2. …”
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    A national initiative in data science for health: an evaluation of the UK Farr Institute
  10. 144330
    “…During a median follow-up of 82 (IQR, 60–98) days, 27 (52.9%) patients experienced a total of 39 AKI episodes, translating into one AKI episode per 100 patient days. …”
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    Phenotypes and Baseline Risk Factors of Acute Kidney Injury in Children After Allogeneic Hematopoietic Stem Cell Transplantation
  11. 144331
    “…Diversity assessments based on sequences of the effector SIX3- and the translation elongation factor 1-α encoding genes SIX3 and tef1-α, respectively were the most informative to differentiate pathogenic races of FOL and resulted in race 1, forming a monophyletic clade while race 3 comprised multiple clades. …”
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    Pathogenomics Characterization of an Emerging Fungal Pathogen, Fusarium oxysporum f. sp. lycopersici in Greenhouse Tomato Production Systems
  12. 144332
    “…RESULTS: Combination of proteomics and Western blot analyses showed increased AMPK activity while the activity of nutrient sensor mTORC1 was decreased by Aramchol in hepatocytes. This translated into changes in the content of their downstream targets including proteins involved in fatty acid (FA) synthesis and oxidation [P-ACCα/β(S79), SCD1, CPT1A/B, HADHA, and HADHB], oxidative phosphorylation (NDUFA9, NDUFB11, NDUFS1, NDUFV1, ETFDH, and UQCRC2), tricarboxylic acid (TCA) cycle (MDH2, SUCLA2, and SUCLG2), and ribosome (P-p70S6K[T389] and P-S6[S235/S236]). …”
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    Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation
  13. 144333
    “…The KT-1000 arthrometer showed a difference in the anterior translation of less than 3 mm (mean 1.0 ± 1.2, range − 1 to 5 mm) in 91% of the patients. …”
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    Quadriceps tendon vs. patellar tendon autograft for ACL reconstruction using a hardware-free press-fit fixation technique: comparable stability, function and return-to-sport level but less donor site morbidity in athletes after 10 years
  14. 144334
    “…The data were transcribed verbatim, translated from Amharic and Afan Oromo into English and analyzed through a theoretical framework named the Bergen Model of Collaborative Functioning (BMCF). …”
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    Accelerating the performance of district health systems towards achieving UHC via twinning partnerships
  15. 144335
    “…As proof-of-concept, our preliminary work demonstrated a successful example of visualizing mGlu(2) in vivo derived from NAMs, which represents a promising chemotype for further development and optimization aimed for clinical translation.…”
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    Synthesis and preliminary studies of (11)C-labeled tetrahydro-1,7-naphthyridine-2-carboxamides for PET imaging of metabotropic glutamate receptor 2
  16. 144336
    “…BACKGROUND: Few efficacious pediatric obesity interventions have been successfully translated and sustained in real-world practice, often due to inadequate fit with the priorities of under-resourced populations. …”
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    Raising Well at Home: a pre-post feasibility study of a lifestyle intervention for caregivers and their child with obesity
  17. 144337
    “…These predictions can be translated into policy decisions such as when increased efforts are needed to reach children and what type of service delivery modalities may be the most effective. …”
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    A predictive model for healthcare coverage in Yemen
  18. 144338
    “…CONCLUSIONS: An SMS program increased self-reported adherence to unsupervised home exercise in people with knee OA and obesity, although this did not translate into improved clinical outcomes. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry 12617001243303; https://tinyurl.com/y2ud7on5 INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.1186/s12891-019-2801-z…”
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    Behavior Change Text Messages for Home Exercise Adherence in Knee Osteoarthritis: Randomized Trial
  19. 144339
    “…The resulting investigations offer the potential to provide highly translatable information for research and prevention efforts.…”
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    Development and Acceptability of a Method to Investigate Prescription Drug Misuse in Daily Life: Ecological Momentary Assessment Study
  20. 144340
    “…The results from this model can potentially be translated into the clinics for reinforcing the femoral neck or for enhancing implant anchorage in poor-quality osteoporotic bone, which presents a real clinical challenge in fragility fractures.…”
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    Long-Term Response to a Bioactive Biphasic Biomaterial in the Femoral Neck of Osteoporotic Rats
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