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  1. 144361
    “…It is discussed that senescence-associated circRNAs were involved in flag leaf senescence probably through mediating their parental genes and ceRNA networks, to participate in several well-studied senescence-associated processes, mainly including the processes of transcription, translation, and posttranslational modification (especially protein glycosylation), oxidation–reduction process, involvement of senescence-associated genes, hormone signaling pathway, proteolysis, and DNA damage repair. …”
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    Systematic identification and characterization of circular RNAs involved in flag leaf senescence of rice
  2. 144362
    “…CONCLUSIONS: Our results suggest that addition of PRSs to conventional risk factors can modestly enhance prediction of first-onset CVD and could translate into population health benefits if used at scale.…”
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    Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses
  3. 144363
    “…These results equate to a mean saving of 47.60 working hours. Moreover, it translates to 3.30 fewer full-time equivalents (raw phone call data), resulting in 1.1 fewer full-time equivalents required to monitor 100 patients when adjusted for time spent reviewing app data. …”
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    Mobile App–Based Remote Patient Monitoring in Acute Medical Conditions: Prospective Feasibility Study Exploring Digital Health Solutions on Clinical Workload During the COVID Crisis
  4. 144364
    “…FUNDING: National Heart, Lung, and Blood Institute; Agency for Healthcare Research and Quality; Patient-Centered Outcomes Research Institute; Minnesota Learning Health System Mentored Training Program, M Health Fairview Institutional Funds; National Center for Advancing Translational Sciences; and National Cancer Institute.…”
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    Metformin and risk of mortality in patients hospitalised with COVID-19: a retrospective cohort analysis
  5. 144365
    “…As DFO-B is used in clinic for many years and the estimated radiation dose is lower than for other (68)Ga-labelled radiopharmaceuticals, we believe that [(68)Ga]Ga-DFO-B has a great potential for clinical translation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00259-020-04948-y) contains supplementary material, which is available to authorized users.…”
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    (68)Ga-labelled desferrioxamine-B for bacterial infection imaging
  6. 144366
    “…We observed a decrease in stroke volume index (−2.04 mL/m(2)/point) and mean transvalvular gradients (−1.14 mmHg/point) with increasing H(2)FPEF score translating into a higher prevalence of paradoxical low‐flow, low‐gradient AS among patients with high H(2)FPEF score. …”
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    Prognostic value of the H(2)FPEF score in patients undergoing transcatheter aortic valve implantation
  7. 144367
    “…Seventy-eight adolescents and young adults with ASD, without intellectual impairment, aged between 16 and 38 (M = 22.77; SD = 5.31), were recruited from the community, Headspace centres and the Autism Clinic for Translational Research at the Brain and Mind Centre, University of Sydney. …”
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    Modified CBT for social anxiety and social functioning in young adults with autism spectrum disorder
  8. 144368
    “…RESULTS: We show a decline in phosphorylation of mTORC1 downstream substrate 4E-BP1 (eukaryotic translation initiation factor 4E-binding protein 1) in response to treatment with aspirin and its metabolite salicylic acid in MDA-MB-468, MCF-7, MDA-MB-231, and MCF10A cell lines. …”
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    siRNA Knockdown of REDD1 Facilitates Aspirin-Mediated Dephosphorylation of mTORC1 Target 4E-BP1 in MDA-MB-468 Human Breast Cancer Cell Line
  9. 144369
    “…All interviews were recorded, transcribed, and translated for a content analysis using Dedoose. Cohen’s Kappa was 89.4% across coded excerpts. …”
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    The acceptability and feasibility of a pilot study examining the impact of a mobile technology-based intervention informed by behavioral economics to improve HIV knowledge and testing frequency among Latinx sexual minority men and transgender women
  10. 144370
    “…Women were placed in a double bind by being expected to prevent both pregnancy and Zika, in a context where gendered power imbalances often translate in women having little power/means for condom negotiation/avoiding unprotected sexual intercourse. …”
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    Zika virus public health crisis and the perpetuation of gender inequality in Brazil
  11. 144371
    “…The findings have translational potential for novel, improved treatments. …”
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    Modulating gut microbiota in a mouse model of Graves’ orbitopathy and its impact on induced disease
  12. 144372
    “…Importantly, no expression of UMG1-epitope was found in normal tissues/cells, excluding cortical thymocytes and a minority (<5%) of peripheral blood T lymphocytes. ahUMG1 induced strong ADCC and ADCP on T-ALL cells in vitro, which translated in antitumor activity in vivo and significantly extended survival of treated mice. …”
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    Therapeutic afucosylated monoclonal antibody and bispecific T-cell engagers for T-cell acute lymphoblastic leukemia
  13. 144373
    “…This dual approach was chosen because of their complementarity; conventional 2-D radiographs translate to clinical practice but 3-D navigation-based digitalization combined with CT allows for a better understanding of the cortical lines that comprise the outline of the trochanteric fossa. …”
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    Anatomical Mapping of the External Obturator Footprint: A Study In Cadavers with Implications for Direct Anterior THA
  14. 144374
    “…We addressed this gap using an integrated knowledge translation method and patient engagement principles. …”
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    A Web-Based Self-Management Support Prototype for Adults With Chronic Kidney Disease (My Kidneys My Health): Co-Design and Usability Testing
  15. 144375
    “…IMPORTANCE The HSV-1 virion host shutoff (vhs) protein efficiently cleaves both host and viral mRNAs in a translation-dependent manner. In this study, we model and quantify changes in vhs activity, as well as virus-induced global loss of host transcriptional activity, during productive HSV-1 infection. …”
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    Dissecting Herpes Simplex Virus 1-Induced Host Shutoff at the RNA Level
  16. 144376
    “…Thus, since the scientific knowledge on HIV is not translated into technological products, preventing the emergence of new infections, especially in the more vulnerable groups, is difficult. …”
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    mHealth Strategies Related to HIV Postexposure Prophylaxis Knowledge and Access: Systematic Literature Review, Technology Prospecting of Patent Databases, and Systematic Search on App Stores
  17. 144377
    “…Workshop artifacts were used in a knowledge translation process, which identified key learnings to inform user journeys, user personas, and the customization and configuration of the InnoWell Platform for Butterfly’s National Helpline. …”
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    Technology-Enabled Reform in a Nontraditional Mental Health Service for Eating Disorders: Participatory Design Study
  18. 144378
    “…A total of 62 shared DAPs were identified and primarily enriched in proteins related to ‘carbon transport and mechanism’, ‘the response to oxidative stress’, ‘antioxidative activity’ and ‘translation’. KEGG and GO databases showed that the DAPs were enriched in terms of ‘primary metabolisms (amino acid/fatty acid/energy metabolism)’, ‘the response to oxidative stress’ and ‘peroxidase’. …”
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    iTRAQ-based comparative proteome analyses of different growth stages revealing the regulatory role of reactive oxygen species in the fruiting body development of Ophiocordyceps sinensis
  19. 144379
    “…Future in vivo studies should focus on clinical translation by exploring whether SGLT2 inhibitors limit infarct size in animals with relevant comorbidities, on top of loading doses of antiplatelet agents. …”
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    Sodium–glucose cotransporter 2 inhibitors reduce myocardial infarct size in preclinical animal models of myocardial ischaemia–reperfusion injury: a meta-analysis
  20. 144380
    “…Placental protein or mRNA expression of eukaryotic translation initiation factor binding protein-1 (4E-BP1), ribosomal protein S6 (rpS6), AMP-activated protein kinase α (AMPKA), IGF-1, insulin-like growth factor receptor (IGF-1R), and pregnancy associated plasma protein (PAPP)-A, and DNA methylation of the IGF1 promoter were determined. …”
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    Preconceptional Lipid-Based Nutrient Supplementation in 2 Low-Resource Countries Results in Distinctly Different IGF-1/mTOR Placental Responses
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