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144421por Hallal, Mahmoud, Braga-Lagache, Sophie, Jankovic, Jovana, Simillion, Cedric, Bruggmann, Rémy, Uldry, Anne-Christine, Allam, Ramanjaneyulu, Heller, Manfred, Bonadies, Nicolas“…CONCLUSIONS: We developed and validated a novel KAEA pipeline for the analysis of differential phosphoproteomics MS profiling data. We provide translational researchers with an improved instrument to characterize the biological behavior of kinases in response or resistance to targeted treatment. …”
Publicado 2021
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144422“…BACKGROUND: Slipped capital femoral epiphysis (SCFE) is characterized by translation of the proximal femoral epiphysis posterior and medial relative to the metaphysis. …”
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144423“…In children with ACL tears, appropriate diagnosis and management of medial meniscal pathology is important to maintain secondary restraint to anterior tibial translation and prevent premature graft failure. Pediatric knees can have tight medial compartments, making access difficult, potentially leading to poor visualization and iatrogenic chondral damage. …”
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144424por Roy, Jyoti, Warner, Blake M., Basuli, Falguni, Zhang, Xiang, Zheng, Changyu, Goldsmith, Corrine, Phelps, Tim, Wong, Karen, Ton, Anita T., Pieschl, Rick, White, Margaret E., Swenson, Rolf, Chiorini, John A., Choyke, Peter L., Lin, Frank I.“…This novel approach is easily translatable to clinical practice and has the potential to mitigate xerostomia, without compromising the therapeutic efficacy of the PSMA-TRT. …”
Publicado 2021
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144425Development of Randomized Trials in Adults with Medulloblastoma—The Example of EORTC 1634-BTG/NOA-23por Hau, Peter, Frappaz, Didier, Hovey, Elizabeth, McCabe, Martin G., Pajtler, Kristian W., Wiestler, Benedikt, Seidel, Clemens, Combs, Stephanie E., Dirven, Linda, Klein, Martin, Anazodo, Antoinette, Hattingen, Elke, Hofer, Silvia, Pfister, Stefan M., Zimmer, Claus, Kortmann, Rolf-Dieter, Sunyach, Marie-Pierre, Tanguy, Ronan, Effeney, Rachel, von Deimling, Andreas, Sahm, Felix, Rutkowski, Stefan, Berghoff, Anna S., Franceschi, Enrico, Pineda, Estela, Beier, Dagmar, Peeters, Ellen, Gorlia, Thierry, Vanlancker, Maureen, Bromberg, Jacoline E. C., Gautier, Julien, Ziegler, David S., Preusser, Matthias, Wick, Wolfgang, Weller, Michael“…In summary, we will generate unprecedented data that will be translated into treatment changes in post-pubertal patients with medulloblastoma and will help to design future clinical trials.…”
Publicado 2021
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144426por Hicks, Patrice M., Au, Elizabeth, Self, William, Haaland, Benjamin, Feehan, Michael, Owen, Leah A., Siedlecki, Adam, Nuttall, Elizabeth, Harrison, Deborah, Reynolds, Andrew L., Lillvis, John H., Sieminski, Sandra, Shulman, Julia P., Barnoya, Margarita, Noguera Prera, Juan Jose, Gonzalez, Orlando, Murtaugh, Maureen A., Williams, Lloyd B., Farkas, Michael H., Crandall, Alan S., DeAngelis, Margaret M.“…Interpreters were available for translation to the patients’ native dialect, to assist participants during their visit. …”
Publicado 2021
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144427“…Gene Ontology and KEGG pathway analyses for predicted target genes demonstrated enrichment in cellular processes related to metabolism, transcription, translation, signal transduction, cell differentiation, migration, and angiogenesis.…”
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144428por Rafiei Alavi, Seyedeh Niloufar, Madani Neishaboori, Arian, Hossein, Hasti, Sarveazad, Arash, Yousefifard, Mahmoud“…Given the remarkable bias about blinding, clinical translation of the present results is tough, because in addition to the complexity of the nervous system and the involvement of far more complex motor circuits in the human, blinding compliance and motor outcome assessment tests in animal studies and clinical trials are significantly different. …”
Publicado 2021
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144429por Martin, Blake, DeWitt, Peter E., Russell, Seth, Anand, Adit, Bradwell, Katie R., Bremer, Carolyn, Gabriel, Davera, Girvin, Andrew T., Hajagos, Janos G., McMurry, Julie A., Neumann, Andrew J., Pfaff, Emily R., Walden, Anita, Wooldridge, Jacob T., Yoo, Yun Jae, Saltz, Joel, Gersing, Ken R., Chute, Christopher G., Haendel, Melissa A., Moffitt, Richard, Bennett, Tellen D.“…Further work is needed to translate this knowledge into improved outcomes.…”
Publicado 2021
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144430por Widner, D. Brooke, Liu, Chun, Zhao, Qingxia, Sharp, Sarah, Eber, Matthew R., Park, Sun H., Files, D. Clark, Shiozawa, Yusuke“…In vitro measurements included C2C12 myotube diameter before and after treatment with media from primary murine mast cells activated with LL/2 conditioned media. To assess translational potential in human samples, innate immune cell signatures were assessed for correlation with skeletal muscle atrophy and apoptosis, dietary excess, and cachexia signatures in normal skeletal muscle tissue. …”
Publicado 2021
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144431por Silva, Gleise M, Cangiano, Lautaro R, Fabris, Thiago F, Merenda, Victoria R, Chebel, Ricardo C, Dubeux, Jose Carlos Batista, DiLorenzo, Nicolas, Laporta, Jimena“…In conclusion, providing artificial shade during summer to pregnant grazing beef heifers was effective in reducing vaginal temperatures and exerted changes in heifer behaviors that translated into slight improvements in growth performance.…”
Publicado 2021
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144432por Peebles, Kathryn, Mugwanya, Kenneth K., Irungu, Elizabeth, Odoyo, Josephine, Wamoni, Elizabeth, Morton, Jennifer F., Ngure, Kenneth, Bukusi, Elizabeth A., Mugo, Nelly R., Masyuko, Sarah, Mukui, Irene, Baeten, Jared M., Barnabas, Ruanne V.“…The total financial cost to the Ministry of Health was $91,175, translating to an average of $10.31 per person per month. …”
Publicado 2021
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144433por Fong, Wei Chern Gavin, Grevatt, Susan, Potter, Stephen, Tidbury, Tracey, Kadalayil, Latha, Bennett, Kaisha, Larsson, Maria, Nicolas, Frédéric, Kurukulaaratchy, Ramesh, Arshad, Syed Hasan“…Furthermore, this trial is conducted at a single center and in a location with a homogenous cohort of people, which may affect translatability. Nonetheless, it is hoped that the findings of this trial may help further inform clinicians regarding the utility of this novel device as an adjunct in asthma care. …”
Publicado 2021
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144434por Yilmaz, Müjgan, Holm, Christina Enciso, Lind, Thomas, Flivik, Gunnar, Odgaard, Anders, Petersen, Michael Mørk“…RSA results were presented as maximal total point of motion (MTPM) and segmental motion (translation and rotation), and DXA results were presented as changes in BMD in different regions of interest (ROI). …”
Publicado 2021
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144435“…Implications for practice include use of adult learning theory, didactic training, custom coded language and a reactive process which has translated to practice changes and established competency standards. …”
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144436por Mishra, Ninad, Duke, Jon, Karki, Saugat, Choi, Myung, Riley, Michael, Ilatovskiy, Andrey V, Gorges, Marla, Lenert, Leslie“…Predetermined queries were translated into Clinical Quality Language logics. Within the PACER environment, these Clinical Quality Language logical statements were managed and evaluated against the providers’ FHIR servers. …”
Publicado 2021
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144437por Liu, Tao, Shi, Qiao, Yang, Lei, Wang, Shusen, Song, Hongli, Wang, Zhenglu, Xu, Xinnv, Liu, Hongsheng, Zheng, Hong, Shen, Zhongyang“…HERH-4 acted as an miR-29b/c sponge to facilitate CCNA2 protein translation through a competing endogenous RNA (ceRNA) pathway. …”
Publicado 2021
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144438por Hanna, Catherine R., O’Cathail, Sean M., Graham, Janet S., Saunders, Mark, Samuel, Leslie, Harrison, Mark, Devlin, Lynsey, Edwards, Joanne, Gaya, Daniel R., Kelly, Caroline A., Lewsley, Liz-Anne, Maka, Noori, Morrison, Paula, Dinnett, Louise, Dillon, Susan, Gourlay, Jacqueline, Platt, Jonathan J., Thomson, Fiona, Adams, Richard A., Roxburgh, Campbell S. D.“…Secondary endpoints include treatment compliance, toxicity, safety, overall recurrence, proportion of patients with a permanent stoma, and survival. The study is translationally rich with collection of bio-specimens prior to, during, and following treatment in order to understand the molecular and immunological factors underpinning treatment response. …”
Publicado 2021
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144439por Li, Yajuan, Zhang, Yaohua, Hu, Qingsong, Egranov, Sergey D., Xing, Zhen, Zhang, Zhao, Liang, Ke, Ye, Youqiong, Pan, Yinghong, Chatterjee, Sujash S., Mistretta, Brandon, Nguyen, Tina K., Hawke, David H., Gunaratne, Preethi H., Hung, Mien-Chie, Han, Leng, Yang, Liuqing, Lin, Chunru“…Human induced pluripotent stem-derived skeletal muscle cells (iPSC-SkMC) from a healthy donor and Becker Muscular Dystrophy (BMD) patients were utilized to study DMD post-translational modifications and associated proteins. …”
Publicado 2021
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144440por Wang, Gang, Zhou, Fangzheng, Ou, Tong, Sun, Haiyan, Shan, Zhirui, Lu, Yingshen, Chen, Gui, Yuan, Simin, Zhang, Xiaowen, Wu, Song“…Mechanistically, miR-182-5p interacted with ZFP36L1 at two sites in its 3′ un-translated region (UTR) and repressed ZFP36L1 expression in NPC. …”
Publicado 2021
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