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  1. 144461
    “…BACKGROUND: Mitochondrial DNA (mtDNA) codes for products necessary for electron transport and mitochondrial gene translation. mtDNA mutations can lead to human disease and influence organismal fitness. …”
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    The mtDNA mutation spectrum in the PolG mutator mouse reveals germline and somatic selection
  2. 144462
    “…Secondly, module 2 (M2) exploits data provided by the Italian birth cohort called Nascita e Infanzia: gli Effetti dell’Ambiente (NINFEA), translated as Birth and Childhood: the Effects of the Environment study, and runs a series of concatenated regressions in order to estimate the prospective effects of income on child body mass index (BMI) at different ages. …”
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    Developing an integrated microsimulation model for the impact of fiscal policies on child health in Europe: the example of childhood obesity in Italy
  3. 144463
    “…Specific questions addressed included the value of clinical presentation and imaging in selecting patients for procedures, whether conservative treatment should be used before injections, whether imaging is necessary for blocks, diagnostic and prognostic value of medial branch blocks and intra-articular joint injections, the effects of sedation and injectate volume on validity, whether facet blocks have therapeutic value, what the ideal cut-off value is for designating a block as positive, how many blocks should be performed before radiofrequency ablation, the orientation of electrodes, whether larger lesions translate into higher success rates, whether stimulation should be used before radiofrequency ablation, how best to mitigate complication risks, if different standards should be applied to clinical practice and trials, and the indications for repeating radiofrequency ablation. …”
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    Consensus practice guidelines on interventions for cervical spine (facet) joint pain from a multispecialty international working group
  4. 144464
    “…Conclusion: A well-designed health worker intervention package incorporated into the existing health system can translate into attitude change and skill development in the health workers which can reflect in the improvement of glycemic control among the patients. …”
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    Effectiveness of a Non-pharmacological Intervention to Control Diabetes Mellitus in a Primary Care Setting in Kerala: A Cluster-Randomized Controlled Trial
  5. 144465
    “…We aimed to analyze fecal microbial composition and function in a translationally relevant baboon model of chronic heavy drinking that also meets binge criteria (drinking too much, too fast, and too often), i.e., alcohol ~1 g/kg and blood alcohol levels (BALs) ≥ 0.08 g/dL in a 2-hour period, daily, for years. …”
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    Gut microbiome and metabolome in a non-human primate model of chronic excessive alcohol drinking
  6. 144466
    “…Specific questions addressed included the value of clinical presentation and imaging in selecting patients for procedures, whether conservative treatment should be used before injections, whether imaging is necessary for blocks, diagnostic and prognostic value of medial branch blocks and intra-articular joint injections, the effects of sedation and injectate volume on validity, whether facet blocks have therapeutic value, what the ideal cut-off value is for designating a block as positive, how many blocks should be performed before radiofrequency ablation, the orientation of electrodes, whether larger lesions translate into higher success rates, whether stimulation should be used before radiofrequency ablation, how best to mitigate complication risks, if different standards should be applied to clinical practice and trials, and the indications for repeating radiofrequency ablation. …”
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    Online Artículo Texto
    Consensus practice guidelines on interventions for cervical spine (facet) joint pain from a multispecialty international working group
  7. 144467
    “…Other specific features in the development of these instruments, namely their incremental adoption, ongoing evaluation and strong practice orientation, were also found to be suitable for other care contexts’ attempts to respond to the top-down policy objectives of client-centeredness and translating outcomes into direct care practice.…”
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    A sector-wide response to national policy on client-centred care and support: a document analysis of the development of a range of instruments to assess clients’ experiences in the care and support for people with (intellectual) disabilities
  8. 144468
    “…Gene network analyses indicated a general dysregulation of gene inter-connections. CONCLUSION: This translational genomics study highlighted the existence both of individual genes, mostly dysregulated in certain cellular populations (e.g., macrophages), and gene-networks involved in pulmonary reaction after left pneumonectomy. …”
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    Genome-wide expression of the residual lung reacting to experimental Pneumonectomy
  9. 144469
    “…The improvement of gross energy digestibility in pigs was 1.08% unit with 95% CI (0.90; 1.26) translating to the release of between 30.6 and 42.8 kcal/kg of digestible energy. …”
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    Significance of single β-mannanase supplementation on performance and energy utilization in broiler chickens, laying hens, turkeys, sows, and nursery-finish pigs: a meta-analysis and systematic review
  10. 144470
    “…In addition, the XGBoost model was translated into a self-made web-based risk calculator to estimate an individual’s probability of ONFH. …”
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    Prediction Model of Osteonecrosis of the Femoral Head After Femoral Neck Fracture: Machine Learning–Based Development and Validation Study
  11. 144471
    “…AGPs biosynthesis involves a series of post-translational modifications including the addition of type II arabinogalactans to non-contiguous Hyp residues. …”
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    Functional characterization of hydroxyproline-O-galactosyltransferases for Arabidopsis arabinogalactan-protein synthesis
  12. 144472
    “…Clinically relevant preclinical models are essential for evaluating interventions for human translation, yet few exist that accurately mimic all key HTx components, incorporating injuries beginning in the donor, through to the recipient. …”
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    A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death
  13. 144473
    por Kim, Jaeyoung, Day, Jonathan
    Publicado 2020
    “…In addition, the posterior calcaneal tuber translates medially after displacement, resulting in altered anatomical geometry. …”
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    Establishing a New Bony Landmark for Safe Screw Insertion in Medial Displacement Calcaneal Osteotomy: A Simulation-Based Approach
  14. 144474
    “…They were audio-recorded, translated and transcribed into English and were thematically analyzed. …”
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    Factors affecting utilization of sexual and reproductive health services among women with disabilities- a mixed-method cross-sectional study from Ilam district, Nepal
  15. 144475
    “…An independent group of double-hit APPPS1 mice with dysfunctional microglia due to knockout of triggering receptor expression on myeloid cells 2 (Trem2(−/−)) served for validation and evaluation of translational impact. Results: Neither fibrillar nor nonfibrillar Aβ content alone sufficed to explain the Aβ PET findings in either AD model. …”
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    Glitter in the Darkness? Nonfibrillar β-Amyloid Plaque Components Significantly Impact the β-Amyloid PET Signal in Mouse Models of Alzheimer Disease
  16. 144476
    “…CONCLUSIONS: We found between‐study differences in mean grip strength that are likely to translate into greater future risk of sarcopenia and poorer prospects of healthy ageing for Russian than Norwegian study participants. …”
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    Between‐study differences in grip strength: a comparison of Norwegian and Russian adults aged 40–69 years
  17. 144477
    “…Our results provide translationally relevant evidence that VCP inhibitors could be beneficial in the treatment of VCP disease. …”
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    VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy
  18. 144478
    por Jácome, Cristina, Almeida, Rute, Pereira, Ana Margarida, Amaral, Rita, Vieira-Marques, Pedro, Mendes, Sandra, Alves-Correia, Magna, Ferreira, José Alberto, Lopes, Inês, Gomes, Joana, Araújo, Luís, Couto, Mariana, Chaves Loureiro, Cláudia, Santos, Lilia Maia, Arrobas, Ana, Valério, Margarida, Todo Bom, Ana, Azevedo, João, Teixeira, Maria Fernanda, Ferreira-Magalhães, Manuel, Pinto, Paula Leiria, Pinto, Nicole, Neves, Ana Castro, Morête, Ana, Bom, Filipa Todo, Costa, Alberto, Silva, Diana, Vasconcelos, Maria João, Falcão, Helena, Marques, Maria Luís, Mendes, Ana, Cardoso, João, Cidrais Rodrigues, José Carlos, Oliveira, Georgeta, Carvalho, Joana, Lozoya, Carlos, Santos, Natacha, Menezes, Fernando, Gomes, Ricardo, Câmara, Rita, Alves, Rodrigo Rodrigues, Moreira, Ana Sofia, Abreu, Carmo, Silva, Rui, Bordalo, Diana, Alves, Carlos, Lopes, Cristina, Taborda-Barata, Luís, Fernandes, Ricardo M., Ferreira, Rosário, Chaves-Loureiro, Carla, Cálix, Maria José, Alves, Adelaide, Fonseca, João Almeida
    Publicado 2021
    “…Patients interacted with the app for a median of 18 [3–45] days, translated on a median use rate of 15 [3–38]%. Median inhaler adherence assessed through the app was 34 [4–73]% when considering all scheduled inhalations for the study period. …”
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    Monitoring Adherence to Asthma Inhalers Using the InspirerMundi App: Analysis of Real-World, Medium-Term Feasibility Studies
  19. 144479
    por Tan, Poh Lin
    Publicado 2022
    “…Stress, fatigue, and marital satisfaction levels predicted probability of non-activity and sexual frequency. CLINICAL TRANSLATION: The increase in weekly sexual frequency has implications for sexual and reproductive health, including sexual satisfaction and prevalence of infertility and low birth weight associated with waiting time to pregnancy. …”
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    Changes in Frequency and Patterns of Marital Sexual Activity During COVID-19: Evidence From Longitudinal Data Prior to, During and After Lockdown in Singapore
  20. 144480
    “…There were significant differences in the frames’ mechanical behaviour under different loading conditions but further research is required to determine whether these translate in vivo into clinical significance. HOW TO CITE THIS ARTICLE: Fenton C, Henderson D, Samchukov M, et al. …”
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    Comparative Stiffness Characteristics of Ilizarov- and Hexapod-type External Frame Constructs
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