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144541por Riillo, Caterina, Caracciolo, Daniele, Grillone, Katia, Polerà, Nicoletta, Tuccillo, Franca Maria, Bonelli, Patrizia, Juli, Giada, Ascrizzi, Serena, Scionti, Francesca, Arbitrio, Mariamena, Lopreiato, Mariangela, Siciliano, Maria Anna, Sestito, Simona, Talarico, Gabriella, Galea, Eulalia, Galati, Maria Concetta, Pensabene, Licia, Loprete, Giovanni, Rossi, Marco, Ballerini, Andrea, Gentile, Massimo, Britti, Domenico, Di Martino, Maria Teresa, Tagliaferri, Pierosandro, Tassone, Pierfrancesco“…Most importantly, in a PBMC-reconstituted NGS mouse model bearing human T-ALL, CD1a x CD3ε significantly inhibited the growth of human T-ALL xenografts, translating into a significant survival advantage of treated animals. …”
Publicado 2022
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144542por Behrendt, Peter, Herbst, Elmar, Robinson, James R., von Negenborn, Leslie, Raschke, Michael J., Wermers, Jens, Glasbrenner, Johannes, Fink, Christian, Herbort, Mirco, Kittl, Christoph“…The primary outcome measures of this force-controlled setup were anterior tibial translation (ATT; in mm) and axial tibial rotation (in degrees). …”
Publicado 2022
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144543por Farrell, Caitlin, Dorney, Kate, Mathews, Bonnie, Boyle, Tehnaz, Kitchen, Anthony, Doyle, Jeff, Monuteaux, Michael C., Li, Joyce, Walsh, Barbara, Nagler, Joshua, Chung, Sarita“…Follow-up data suggest that knowledge and skills obtained as part of the curriculum was translated into practice. This strategy could be used in future efforts to integrate simulation into EMS practice.…”
Publicado 2022
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144544“…Collagen molecules undergo heavy post-translational modifications (PTMs) mainly hydroxylation of proline, lysine, and glycosylation of lysine during biosynthesis. …”
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144545por Malagola, Michele, Turra, Alessandro, Signorini, Liana, Corbellini, Silvia, Polverelli, Nicola, Masina, Lorenzo, Del Fabro, Giovanni, Lorenzotti, Silvia, Fumarola, Benedetta, Farina, Mirko, Morello, Enrico, Radici, Vera, Buttini, Eugenia Accorsi, Colnaghi, Federica, Bernardi, Simona, Re, Federica, Caruso, Arnaldo, Castelli, Francesco, Russo, Domenico“…In particular, the choice to avoid prophylaxis with fluoroquinolone was associated with an increase in Gram-negative BSIs by day +30, but this did not translate into higher levels of mortality. Moreover, this strategy was associated with a significant reduction of Clostridiodes difficile infections. …”
Publicado 2022
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144546por Hughes, Angela, Matope, Agnes, Emery, Mischa, Steen, Keith, Murray, Gregory, Ranson, Hilary, McCall, Philip J., Foster, Geraldine M.“…It generates two test outputs, knockdown and 24-h mortality, both indicative of immediate toxicity but that reveal little about the nature of mosquito and ITN interaction or how results translate to real-world settings. METHODS: A human arm held 5 mm behind the net surface acted as a host attractant during cone tests and a smartphone was used to capture mosquito behaviour in the cone. …”
Publicado 2022
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144547por Marx, Christian, Sonnemann, Jürgen, Maddocks, Oliver D. K., Marx-Blümel, Lisa, Beyer, Mandy, Hoelzer, Doerte, Thierbach, René, Maletzki, Claudia, Linnebacher, Michael, Heinzel, Thorsten, Krämer, Oliver H.“…This is connected to increased levels of electron transport chain complexes involving mitochondrial translation. Mass spectrometric analysis reveals global metabolic adaptations of CRC cells to irinotecan, including the glycolysis, tricarboxylic acid cycle, and pentose phosphate pathways. …”
Publicado 2022
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144548por Doerstling, Steven S, Akrobetu, Dennis, Engelhard, Matthew M, Chen, Felicia, Ubel, Peter A“…Using pretrained NER and entity resolution models from Spark NLP for Healthcare in combination with targeted keyword searches, we constructed an algorithm to identify conditions in the campaign descriptions, translate conditions to International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) codes, and predict the presence or absence of 11 disease categories in the campaigns. …”
Publicado 2022
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144549por D'Andrea, David, Shariat, Shahrokh F., Soria, Francesco, Mari, Andrea, Mertens, Laura S., Di Trapani, Ettore, Carrion, Diego M., Pradere, Benjamin, Pichler, Renate, Filippot, Ronan, Grisay, Guillaume, Del Giudice, Francesco, Laukhtina, Ekaterina, Paulnsteiner, David, Krajewski, Wojciech, Vallet, Sonia, Maggi, Martina, De Berardinis, Ettore, Álvarez-Maestro, Mario, Brönimann, Stephan, Di Maida, Fabrizio, van Rhijn, Bas W.G., Hendricksen, Kees, Moschini, Marco“…Patients with primary MIBC had a better response to NAC but this did not translate to better survival after accounting for other tumor characteristics.…”
Publicado 2022
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144550por Wang, Qiuju, Ren, Yulong, Cui, Yizhe, Gao, Bingnan, Zhang, Hao, Jiang, Qianming, Loor, Juan J., Deng, Zhaoju, Xu, Chuang“…RESULTS: The mRNA levels of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta (PIK3CB), serine/threonine kinase (AKT), mTOR, P70S6K1, and eukaryotic translation initiation factor 4E binding protein 1 were the highest (p < 0.01), while those of programmed cell death 4 were the lowest when the tissue was incubated with 10(7) of B. subtilis. …”
Publicado 2022
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144551por Nozawa, Kaori, Fujihara, Yoshitaka, Devlin, Darius J., Deras, Ricardo E., Kent, Katarzyna, Larina, Irina V., Umezu, Kohei, Yu, Zhifeng, Sutton, Courtney M., Ye, Qiuji, Dean, Laura K., Emori, Chihiro, Ikawa, Masahito, Garcia, Thomas X., Matzuk, Martin M.“…BACKGROUND: Ubiquitination is a post-translational modification required for a number of physiological functions regulating protein homeostasis, such as protein degradation. …”
Publicado 2022
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144552por Mitchell, Sharon, Jaccard, Evrim, Schmitz, Felix Michael, von Känel, Elianne, Collombet, Prune, Cornuz, Jacques, Waeber, Gérard, Guessous, Idris, Guttormsen, Sissel“…The focus groups were audio recorded, transcribed by intelligent verbatim and translated to English. NVivo was used for data analysis and interpretation following a hybrid approach using the Framework Method and thematic analysis. …”
Publicado 2022
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144553por Chen, Bojie, Lei, Shuwen, Yin, Xinlu, Fei, Mengjia, Hu, Yixin, Shi, Yuan, Xu, Yanan, Fu, Lei“…The results provide new insights into the antitumor potential and clinical translation of mitochondrial inhibitors.…”
Publicado 2022
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144554por Tossaint-Schoenmakers, Rosian, Kasteleyn, Marise J, Rauwerdink, Anneloek, Chavannes, Niels, Willems, Sofie, Talboom-Kamp, Esther P W A“…This study is a follow-up study of a systematic literature review on optimally organizing hybrid health care (eHealth and face to face) using the Donabedian Structure-Process-Outcome (SPO) framework to translate the findings into a modus operandi for health care organizations. …”
Publicado 2022
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144555“…Retention decreased with duration of being in care up to 73.5% (n = 202) at 24 months, and this translates to LTFU of 26.5% (n = 73). Viral load testing coverage was 62% (n = 132) and of these, 90.9% (n = 120) were virally suppressed. …”
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144556por Peng, Cong, Jian, Xingxing, Xie, Yang, Li, Lingfeng, Ouyang, Jian, Tang, Ling, Zhang, Xu, Su, Juan, Zhao, Shuang, Liu, Hong, Yin, Mingzhu, Wu, Dan, Wan, Miaojian, Xie, Lu, Chen, Xiang“…Our findings provide novel potential diagnostic and therapeutic targets for this disease. What is the translational message? Our study revealed novel molecular subtypes of DFSP based on genetic mutations, which benefits precision diagnosis. …”
Publicado 2022
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144557por Kezic, Sanja, McAleer, Maeve A., Jakasa, Ivone, Goorden, Susan M.I., der Vlugt, Karen Ghauharali‐van, Beers‐Stet, Femke S., Meijer, Judith, Roelofsen, Jeroen, Nieman, Monique M., van Kuilenburg, André B.P., Irvine, Alan D.“…The function of glucosylcholesterol and the physiological consequences of increased levels are not clear yet; however, its levels were strongly correlated with skin barrier function: high transepidermal water loss strongly correlated with high levels of glucosylcholesterol. What is the translational message? Correction of cutaneous inflammation largely restores alterations in lipid metabolism in the stratum corneum of infants with AD.…”
Publicado 2022
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144558por Rosen, Kelli A., Thodge, Anay, Tang, Amy, Franz, Brendan M., Klochko, Chad L., Soliman, Steven B.“…Following further studies, this process could translate into a dedicated, simple and noninvasive screening method to detect T2DM with the prospects of identifying even a fraction of the undiagnosed persons worldwide. …”
Publicado 2022
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144559por Stock, Sophia, Benmebarek, Mohamed-Reda, Kluever, Anna-Kristina, Darowski, Diana, Jost, Christian, Stubenrauch, Kay-Gunnar, Benz, Joerg, Freimoser-Grundschober, Anne, Moessner, Ekkehard, Umana, Pablo, Subklewe, Marion, Endres, Stefan, Klein, Christian, Kobold, Sebastian“…CONCLUSIONS: P329G-targeting CAR T cells combined with antigen-binding human IgG1 antibodies containing the P329G Fc mutation mediate pronounced in vitro and in vivo effector functions in different solid tumor models, warranting further clinical translation of this concept.…”
Publicado 2022
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144560por Lin, Junhong, Wu, Sikai, Zhu, Kanghao, Zhang, Jian, Shi, Xiaoshun, Shen, Jianfei, Xu, Jianfeng“…Assessing the miR-145-5p level in ESCC samples has translational meaning, which help illustrate the immune infiltration status, predict the prognostic outcome, and select the type of immunochemotherapy.…”
Publicado 2022
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