“…BACKGROUND: Mammalian cell lines are frequently used as protein expression hosts because of their ability to correctly fold and assemble complex proteins, produce them at high titers, and confer post-translational modifications (PTMs) critical to proper function. …”
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“…Recently, metabolic regulation has been linked to a new post-translational modification, lactylation. Proteomic data were re-analyzed looking for lactylated protein and found, amongst others, PYCRL, an enzyme implicated in proline biosynthesis, as one of the most differentially lactylated proteins in treated cell lines compared to control. …”
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“…Interviews were audio-recorded using digital recorders, stored and transferred to computers, transcribed verbatim by the data collectors, translated into English and then imported into NVivo V.12 software for data analysis. …”
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“…The works described in this thesis had one main goal: to assure best possible performance of the RPC PAC trigger system, which in turn translates into quality of the data acquired by the CMS experiment and – at the end – quality of the physic results. …”
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“…--HTML--><p><em>Lecture will be in English&ndash; Translation available in French</em></p> <p>Without any doubt, CERN can be described as being among the most ambitious scientific enterprises ever undertaken. …”
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“…A focused four-lobed mode distribution is stable and effective in optical tweezer applications, including selective cell pick-up, pairing, grouping or separation, as well as rotation of cell dimers and clusters. Both translational dragging force and rotational torque in the experiments are in good accordance with the theoretical model. …”
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“…These diffusion temperatures are concentration dependent, with aggregation of impurities occurring for the high concentration at lower temperatures than for the low concentration. These findings translate into two key conclusions: at typical growth temperatures (200-300°C) the interstitial Mn is mobile for high concentration (5%) but not for low concentration (1%); and substitutional Mn impurities become mobile in a temperature regime that is well below what has been previously reported. …”
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“…The approach presented has shown promising results and can be translated to a general method for fitting electrical parameters for accelerator magnets.…”
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“…Systems of Units, Significant Figures, Coordinate Systems, and VectorsSystems of UnitsConversion of UnitsSignificant FiguresScientific NotationTrigonometryCoordinate SystemsVectorsAddition and Subtraction of VectorsGuideline for Determining the Direction of the ResultantMotion in One DimensionDisplacementAverage VelocityAverage SpeedInstantaneous VelocityAccelerationEquations of MotionFree-Falling ObjectTwo-Dimensional Motion and Circular MotionDisplacement, Velocity, and AccelerationEquations of Motion in Two DimensionsProjectile MotionUniform Circular MotionLinear Velocity, Angular Velocity, Period, and FrequencyNonuniform Circular MotionNewton's Laws: Implications and ApplicationsStatement of Newton's LawsDiscussion of Newton's Laws of MotionFree Body DiagramRemarks on the Application of Newton's Second and Third LawsNewton's Gravitational LawMass, Weight, and Newton's Gravitational LawNewton's Third Law and Apparent WeightDynamics of a Uniform Circular MotionNewton's Laws: Friction in Linear and Circular MotionsFrictional ForcesBanked RoadsWork and EnergyWorkWork-Energy TheoremConservative ForcesPotential EnergyNonconservative Forces and the Total Mechanical EnergyPowerLinear Momentum and CollisionSystems of ParticlesMotion of the Center of MassLinear Momentum of a System of ParticlesCollisions and Change in Linear MomentumImpulseCollisions in Two DimensionsTypes of CollisionRotational MotionAngular Kinematic QuantitiesRotational Motion in a PlaneTorqueRigid BodyMoment of InertiaParallel Axis TheoremEquilibrium of a Rigid BodyAngular MomentumRotational Kinetic EnergyA Rigid Body in Translational and Rotational MotionsTotal Mechanical Energy of a Rigid BodySimple Harmonic MotionHooke's LawPotential Energy of a SpringMass-Spring System in SHMSimple Pendulum in SHMThermal Physics: Temperature, Heat, and Thermal ExpansionHeat is a Form of Energy, Specific Heat, and Heat CapacityHeat and Internal EnergyZeroth Law of ThermodynamicsThermometers and Temperature ScalesThermal ExpansionCalorimetryHeat Transfer: Transfer by ConductionWaves and Wave MotionWave MotionTypes of WavesMathematical Treatment of an Ideal WaveIntensity of WavesSuperposition of Waves: Interference and Standing WavesFluidsPressure: Definition and UnitsPressure Within FluidsDensity of FluidsVariation of Pressure with Depth in a Static FluidPascal's Principle and ApplicationsArchimedes' PrincipleDynamics of Fluids: Equation of ContinuityBernoulli's EquationElectric Forces and FieldsIntroductionConductors and Insulators: Charged ObjectsCoulomb's LawThe Electric FieldConductors in an Electric FieldGauss' LawElectric Potential Energy and PotentialIntroductionPotential EnergyElectric PotentialElectric Potential of Point charges: Spatially Varying EDirect Current CircuitsIntroductionOhm's LawResistivitySimple CircuitsElectric PowerKirchhoff's RulesCapacitorsMagnetic Forces and FieldsIntroductionThe Magnetic FieldThe Magnetic Force on an Electric CurrentMagnetic Fields Produced by Moving ChargesMagnetic Materials and Permanent MagnetsElectromagnetic InductionIntroductionFaraday's LawElectric GeneratorsSelf-InductanceTransformersAlternating Current Electric CircuitsIntroductionAlternating SignalsPhase Relations in Simple AC CircuitsRCL Series CircuitRoot-Mean-Square Average Values, PowerElectromagnetic WavesIntroductionThe Electromagnetic SpectrumGeometrical OpticsIntroductionWavefronts and RaysReflectionRefractionThin LensesOptical InstrumentsPhysical (Wave) OpticsIntroductionDouble-Slit ExperimentThin-Film InterferenceSingle-Slit DiffractionThe Diffraction GratingPolarizationModern PhysicsIntroductionAtomsLine SpectraThe Bohr ModelBeyond the Bohr ModelThe Periodic Table of ElementsX-RaysQuantum PhysicsThermal RadiationWave-Particle DualityQuantum MechanicsThe Heisenberg Uncertainty PrincipleThe Atomic Nucleus, Radioactivity.…”
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“…One of the setbacks of the LGAD is the relatively large region without multiplication (gain) between the pads, such that there is effectively a dead area with a width of 45-100 𝜇m, depending on the different design choices. This translates into a decreased active area or fill factor, especially in the case of a pixel-like implementation. …”
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“…The results suggested an increase in the size parameters of the UM specimens and comparable data for the applied monitoring instruments, resulting in the CAM-based PDX model becoming an alternative step in translational cancer research for novel diagnostic and therapeutic experimentation in the field of ocular melanoma. …”
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