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  1. 144881
    “…Ubiquitin C-terminal hydrolase1 (UCHL1) was found to be overexpressed in CXCL7-null mice and in the sera of patients with OPLL, and was correlated with OPLL severity. Post-translational modifications of proteins with ubiquitin and ubiquitin-like modifiers, orchestrated by a cascade of specialized ubiquitin activating enzyme (E1), ubiquitin conjugating enzyme (E2), and ubiquitin ligase (E3) enzymes, are thought to control a wide range of cellular processes, and alterations in the ubiquitin–proteasome system have been associated with several degenerative disorders. …”
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    Ubiquitin-dependent proteolysis of CXCL7 leads to posterior longitudinal ligament ossification
  2. 144882
    “…Minigastrin (MG) analogs show high affinity to the cholecystokinin-2 receptor (CCK2R) and have therefore been intensively studied to find a suitable analog for imaging and treatment of CCK2R-expressing tumors. The clinical translation of the radioligands developed thus far has been hampered by high kidney uptake or low enzymatic stability. …”
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    Site-specific stabilization of minigastrin analogs against enzymatic degradation for enhanced cholecystokinin-2 receptor targeting
  3. 144883
    “…MHAV showed all genomic hallmarks defining hepatoviruses, including late-domain motifs likely involved in quasi-envelope acquisition, a predicted C-terminal pX extension of VP1, strong avoidance of CpG dinucleotides, and a type 3 internal ribosomal entry site. Translated polyprotein gene sequence distances of at least 23.7% from other hepatoviruses suggested that MHAV represents a novel Hepatovirus species. …”
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    A Novel Marsupial Hepatitis A Virus Corroborates Complex Evolutionary Patterns Shaping the Genus Hepatovirus
  4. 144884
    “…We conducted quality assurance for translations and coding frameworks through cross comparison of data and used respondent validation to check our results. …”
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    The care, stimulation and nutrition of children from 0-2 in Malawi—Perspectives from caregivers; "Who’s holding the baby?"
  5. 144885
    “…The results demonstrate high sensitivity of the (99m)Tc-labelling strategy, which was shown to strongly influence the receptor affinity, contrary to corresponding agonists. (99m)Tc-SS-04 exhibits excellent pharmacokinetics and imaging properties and appears to be a suitable candidate for SPECT/CT clinical translation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13550-018-0428-y) contains supplementary material, which is available to authorized users.…”
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    The tetraamine chelator outperforms HYNIC in a new technetium-99m-labelled somatostatin receptor 2 antagonist
  6. 144886
    “…The data were initially made available for our study group in order to evaluate a comprehensive evaluation programme in German primary care, the “Hausarztzentrierte Versorgung” (HZV), loosely translated as “family doctor coordinated care”. We used the ICD-10 codes F45.0-F45.9 in regular care to identify patients with somatoform disorders and compared their health care utilization patterns (attendance rates, diagnoses, prescriptions, hospitalization rates) in OOHC to patients without somatoform disorders. …”
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    Patients with somatoform disorders: More frequent attendance and higher utilization in primary Out-of-Hours care?
  7. 144887
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    Presymptomatic white matter integrity loss in familial frontotemporal dementia in the GENFI cohort: A cross‐sectional diffusion tensor imaging study
  8. 144888
    por Zhang, Li
    Publicado 2018
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    AB025. The effects and mechanisms of magnetic nanomaterials in prostate cancer diagnosis and therapy
  9. 144889
    “…FUNDING: National Institute for Health Research Greater Manchester Patient Safety Translational Research Centre.…”
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    Self-harm in a primary care cohort of older people: incidence, clinical management, and risk of suicide and other causes of death
  10. 144890
    por Wiesli, Peter, Schories, Marcus
    Publicado 2018
    “…These properties have been shown to translate into an effective HbA1c reduction with the advantage of a lower risk of hypoglycemia in randomized controlled trials of Gla-300 versus Gla-100. …”
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    Improved Glycemic Control with Insulin Glargine 300 U/mL (Toujeo(®)) in Patients with Type 2 Diabetes: Real-World Effectiveness in Switzerland
  11. 144891
    “…The research suggested higher-than-expected awareness of Latinos and first-generation students of institutional research activities; however, this awareness has not translated in engagement in research activities. The data also indicates the critical need for high-impact UREs and mentorship relationships, as well as for efforts to battle student preconceptions of who can benefit from such experiences. …”
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    Undergraduate research experiences: mentoring, awareness, and perceptions—a case study at a Hispanic-serving institution
  12. 144892
    “…After controlling for urban zip code, weekday, and time of day in regression analyses, total EMS time remained 10% longer (95% CI, 9%-11%; P < .001), translating to 3.8 minutes longer in the poorest zip codes. …”
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    A US National Study of the Association Between Income and Ambulance Response Time in Cardiac Arrest
  13. 144893
    “…Conclusion: [(11)C]NMS-E973 is a PET tracer for in vivo visualisation of tumour HSP90 expression and can potentially be used for quantification of HSP90 occupancy. Further translational evaluation of [(11)C]NMS-E973 is warranted.…”
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    Evaluation of [(11)C]NMS-E973 as a PET tracer for in vivo visualisation of HSP90
  14. 144894
    “…The cytoplasmic Nrf2 content in the Res-treated mice was also decreased while the nuclear Nrf2 content and the nuclear translation rate of Nrf2 were increased (P<0.05). Res could decrease the expression of ERβ in the brain tissue at the mRNA and protein levels and the expression of Aβ in the brain tissue at the protein level. …”
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    Effects of Resveratrol on the Mechanisms of Antioxidants and Estrogen in Alzheimer's Disease
  15. 144895
    “…The studies included were written in the English language or translated to English and they were published between 2008 and 2018. …”
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    Ilizarov bone transport and treatment of critical-sized tibial bone defects: a narrative review
  16. 144896
    “…Purpose: The verification of efficacy of new drug candidates in primate models may address the translational gap between non-clinical and clinical studies and support the prediction of efficacy in humans. …”
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    MON-477 Octreotide and ONO-ST-468, a Novel and Potent Somatostatin Receptor Type-2 (SST2) Agonist, Suppress GH Hypersecretion in the Monkey
  17. 144897
    “…To address this, our group previously developed a more translational model in which peripubertal female rhesus macaques were chronically treated with testosterone (T) implants to achieve modestly elevated serum androgen levels (1.35 ng/mL) in the presence and absence of an obesogenic western-style diet (WSD). …”
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    MON-LB037 The Impact of Maternal Testosterone and Western-Style Diet on the Fetal Hypothalamic-Pituitary-Gonadal Axis
  18. 144898
    “…Because the ovarian attributes of prenatal T-treated sheep parallel that seen in PCOS women, these observations may be of translational relevance. Supported by NIH PO1HD44232.…”
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    MON-202 Changes in the Expression of Epigenetic Enzymes Induced by Prenatal Testosterone Excess May Underlie the Antral Follicular Defects in the Sheep Model of PCOS
  19. 144899
    “…These findings are of translational relevance to female offspring of hyperandrogenic pregnancies. …”
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    MON-LB039 Developmental Programming: Prenatal Testosterone Excess Induces Endoplasmic Reticulum (ER) Stress in the Metabolic Tissues of the Female Sheep
  20. 144900
    “…RT-qPCR studies revealed a transcriptional expression of ESR1 and BRCA-1 mRNA levels that correlate with the translational data obtained via western blot analyses. …”
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    MON-038 The Effects of Isoliquiritigenin (ISL) on the Expression of Estrogen Receptor and Tumor Suppressor Genes BRCA-1 and P53 in Breast Cancer Cells
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