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144901“…MRB and CPC are funded by the NIHR, and this work forms part of the portfolio of translational research of the NIHR Biomedical Research Unit at Barts. …”
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144902por Foidart, Jean-Michel, Arnal, Jean-Francois, Lenfant, Françoise, Taziaux, Mélanie, Houtman, René, Jost, Maud, Lobo, Roger“…The unique profile of E4 activity with lower hepatic effects (minimal or no effects on triglycerides and coagulation) may ultimately translate into safer clinical use. 1) Broekema et al. …”
Publicado 2019
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144903“…However, most of these investigations rely upon rodent tissues, and the translation of these techniques to the human model has proven comparably challenging. …”
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144904“…This effect of DHT on HIF1α protein level was blocked by flutamide (AR inhibitor), LY294002 (PI3K inhibitor) as well as cyclohexamide (protein translational inhibitor). Interestingly the 5’ prime end of JMJD3 have HIF1α response elements (HRE) and it is well established that several JMJDs are induced by HIF1α under both normal conditions and hypoxic stress. …”
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144905“…In parallel we are developing novel anti-CXCR7 therapies that will be translatable into the clinics as a targeted therapy for patients with deadly CRPC.…”
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144906por Burak, M. Furkan, Dagtekin, Nurdan, Bejo, Presila, Vaillancourt, Eric, Liu, Lydia, Gorgun, Cem, Rimm, Eric, Tuncman, Gurol, Hotamisligil, Gokhan“…These data strongly support that aP2 is a mediator of this unique form of airway disease associated with obesity in experimental models. To evaluate the translational implications of these observations, we measured serum aP2 in humans and found 25.4% higher aP2 concentrations (54.5 ± 19.2 vs 43.4 ± 20.1 ng/ml *p<0.05) in overweight and obese asthmatics compared to obese non-asthmatics. …”
Publicado 2019
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144907por Schottelius, Margret, Ludescher, Marina, Richter, Frauke, Kapp, Tobias G., Kessler, Horst, Wester, Hans-Jürgen“…BACKGROUND: The development and clinical translation of [(68)Ga] Pentixafor has substantially promoted the relevance of non-invasive PET imaging of CXCR4 expression in a broad spectrum of diseases, including cancer and inflammation. …”
Publicado 2019
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144908
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144909“…First line palliative chemotherapy improves specific symptoms known to be prevalent and to influence HRQoL in this patient group which in some patients may translate to sustained improvement in HRQoL: further exploration and validation of these findings in larger prospective studies are warranted.…”
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144910por Bakhbakhi, D., Siassakos, D., Lynch, M., Timlin, L., Storey, C., Heazell, A., Burden, C.“…Of the 25 participants, 96% agreed that a face‐to‐face explanation of the PNMR process was of critical importance, 72% considered that parents should be offered the opportunity to nominate a suitable advocate, 92% believed that responses to parents' comments should be formally documented, 96% indicated that it was vital for action plans to be translated into lessons learnt and that this process should be monitored, and 100% of stakeholders voted that a plain‐English summary should be produced for the parents following the meeting. …”
Publicado 2019
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144911por Xu, Xiaoyuan, Feng, Bo, Guan, Yujuan, Zheng, Sujun, Sheng, Jifang, Yang, Xingxiang, Ma, Yuanji, Huang, Yan, Kang, Yi, Wen, Xiaofeng, Li, Jun, Tan, Youwen, He, Qing, Xie, Qing, Wang, Maorong, An, Ping, Gong, Guozhong, Liu, Huimin, Ning, Qin, Hua, Rui, Ning, Bo, Xie, Wen, Zhang, Jiming, Huang, Wenxiang, Yang, Yongfeng, Lin, Minghua, Zhao, Yingren, Yu, Yanhong, Jia, Jidong, Yang, Dongliang, Chen, Liang, Ye, Yinong, Nan, Yuemin, Gong, Zuojiong, Zhang, Quan, Hu, Peng, Wang, Fusheng, Li, Yongguo, Li, Dongliang, Jia, Zhansheng, Hou, Jinlin, Chen, Chengwei, Wu, Jinzi J., Wei, LaiEnlace del recurso
Publicado 2019
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144912por Wei, Lai, Shang, Jia, Ma, Yuanji, Xu, Xiaoyuan, Huang, Yan, Guan, Yujuan, Duan, Zhongping, Zhang, Wenhong, Gao, Zhiliang, Zhang, Mingxiang, Li, Jun, Jia, Jidong, Yang, Yongfeng, Wen, Xiaofeng, Wang, Maorong, Jia, Zhansheng, Ning, Bo, Chen, Yongping, Qi, Yue, Du, Jie, Jiang, Jianning, Tong, Lixin, Xie, Yao, Wu, Jinzi J.Enlace del recurso
Publicado 2019
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