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  1. 145981
    “…We aimed to test the hypothesis that post‐translational modification of SK channels under conditions accompanied by enhanced adrenergic drive plays a central role in disease‐related activation of the channels. …”
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    PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts
  2. 145982
    “…Western blot analysis was then performed to determine the IRS-1, forkhead box O1 (FoxO1), phosphorylated (p-)FoxO1, 78-kDa glucose-regulated protein (GRP78), p-eukaryotic translation initiation factor 2A (eIF2α), CHOP, Akt and p-Akt expression levels. …”
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    Insulin-receptor substrate 1 protects against injury in endothelial cell models of ox-LDL-induced atherosclerosis by inhibiting ER stress/oxidative stress-mediated apoptosis and activating the Akt/FoxO1 signaling pathway
  3. 145983
    “…FUNDING: Funded by the Dutch Postcode Lottery in the Netherlands, Alexander von Humboldt-Stiftung (Humboldt-Stiftung), the Embassy of the Kingdom of the Netherlands in South Africa/Mozambique, British Columbia Centre of Excellence in Canada, Doctors Without Borders (MSF USA), National Center for Advancing Translational Sciences of the National Institutes of Health and Joachim Herz Foundation. …”
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    A stepped-wedge randomised trial on the impact of early ART initiation on HIV-patients’ economic outcomes in Eswatini
  4. 145984
    “…IMPORTANCE: High local recurrence rates with aggressive disease remain the main concern in oral cancer survival. Use of a translational device using fluorescence visualization (FV) approved by the US Food and Drug Administration and Health Canada, has shown a marked reduction in the 3-year local recurrence rate of high-grade oral lesions in a single-center observational study. …”
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    Effect of Fluorescence Visualization–Guided Surgery on Local Recurrence of Oral Squamous Cell Carcinoma: A Randomized Clinical Trial
  5. 145985
    por Shenoy, Niraj
    Publicado 2020
    “…In addition, there was no correlation between HIF1A mRNA and HIF1α protein expression in ccRCC (R = 0.02), reflecting the primarily post-translational regulation of HIF1α. Lastly, even between L2HGDH and HIF1A loci, 14q was found to have several other yet-to-be-characterized potential ccRCC tumor-suppressors. …”
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    HIF1α is not a target of 14q deletion in clear cell renal cancer
  6. 145986
    “…Bevacizumab plus etoposide-based chemotherapy provided the best PFS compared with etoposide-based chemotherapy alone (hazard ratio, 1.54; 95% CI, 1.09-2.27), although this was not translated into OS benefit. The addition of PD-L1 inhibitors to etoposide-platinum chemotherapy caused no more toxic effects in general (compared with etoposide-based chemotherapy alone: OR, 1.14; 95% CI, 0.36-2.31), while bevacizumab plus etoposide-platinum regimen induced the most TRAEs grades 3 to 5 among all first-line treatments (eg, compared with irinotecan-platinum regimen: OR, 4.24; 95% CI, 1.26-14.57). …”
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    Comparison of First-Line Treatments for Patients With Extensive-Stage Small Cell Lung Cancer: A Systematic Review and Network Meta-analysis
  7. 145987
    por He, Yin, Wang, Xiaosheng
    Publicado 2020
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    Identification of molecular features correlating with tumor immunity in gastric cancer by multi-omics data analysis
  8. 145988
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    Predictive value of EGF and uPAR for chemoradiotherapy response and survival in patients with esophageal squamous cell carcinoma
  9. 145989
    “…Consolidation of these principles within the SEG/SEI-(HLA-DQ8) complex constitutes a conceptually new therapeutic weapon with compelling translational potential.…”
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    Endogenous HLA-DQ8αβ programs superantigens (SEG/SEI) to silence toxicity and unleash a tumoricidal network with long-term melanoma survival
  10. 145990
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    Comprehensive bioinformatics analysis of the TP53 signaling pathway in Wilms’ tumor
  11. 145991
    “…BACKGROUND: Implementing the current guidelines for leisure-time physical activity (LTPA) provides significant health benefits, especially for middle-aged adults, but it is unclear whether LTPA also translates into cardiovascular health benefits among elderly people. …”
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    Association of level of leisure-time physical activity with risks of all-cause mortality and cardiovascular disease in an elderly Chinese population: a prospective cohort study
  12. 145992
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    LncRNA HULC shRNA disinhibits miR-377-5p to suppress the growth and invasion of hepatocellular carcinoma in vitro and hepatocarcinogenesis in vivo
  13. 145993
    “…OBJECTIVE: To study whether treatment recommendations based on age and ethnicity according to United Kingdom (UK) clinical guidelines for hypertension translate to blood pressure reductions in current routine clinical care. …”
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    First line drug treatment for hypertension and reductions in blood pressure according to age and ethnicity: cohort study in UK primary care
  14. 145994
    “…Selected data were split in steps (withers and S3 vertical translations) or strides (cannon protraction–retraction) at maximum hind limb protraction, and range of motion (ROM), minima and maxima, and their timing, were extracted. …”
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    Kinematic effects of the circle with and without rider in walking horses
  15. 145995
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    Autophagy-related gene 7 deficiency caused by miR-154-5p overexpression suppresses the cell viability and tumorigenesis of retinoblastoma by increasing cell apoptosis
  16. 145996
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    Factors associated with bronchiectasis in Korea: a national database study
  17. 145997
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    Analysis of the immunoglobin E molecular sensitization profile in children with allergic asthma and predictive factors for the efficacy of allergy immunotherapy
  18. 145998
    “…Using this approach, along with reciprocal translation, enabled the development of 4 themes from the data. …”
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    Digital and Mobile Technologies to Promote Physical Health Behavior Change and Provide Psychological Support for Patients Undergoing Elective Surgery: Meta-Ethnography and Systematic Review
  19. 145999
    “…These data are useful to inform clinicians and organizations about web queries on topics related to ASD, identify knowledge gaps, and target web-based education and knowledge translation strategies.…”
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    Trends in Web Searches About the Causes and Treatments of Autism Over the Past 15 Years: Exploratory Infodemiology Study
  20. 146000
    “…The 3DS method was significantly different from the PM method in all three translation dimensions for both the cranial (P = 0.003–P = 0.03) and body (P < 0.001–P = 0.008) phantoms. …”
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    A phantom study to evaluate three different registration platform of 3D/3D, 2D/3D, and 3D surface match with 6D alignment for precise image‐guided radiotherapy
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