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146341por Ryu, Seungyeon, Yoon, So-Hyun, Song, Junhyuk, Choi, Yoonjung, Lee, Sangeun, Baek, Moonjou, Lee, Han-Byoel, Jeon, Sook Young, Jon, Sangyong, Lee, Daeyoup, Kim, Hoe Suk, Han, Wonshik“…Culturing patient-derived breast cancer cells (PDBCCs) provides an invaluable tool in pre-clinical and translational research for the heterogeneity of cancer cells. …”
Publicado 2023
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146342“…In all countries (1) at the national level, IR teams evaluate the policy environment for scaling up by conducting a desk review and in-depth interviews; (2) at the local level, IR teams implement quantitative questionnaires on structural and organizational readiness to integrate self-injection into the method mix; (3) in “case study” localities, IR teams conduct in-depth interviews and focus group discussions with implementers, method users, and community members; and (4) IR teams use participatory action research to elicit stakeholder participation and translate findings into programmatic decisions. RESULTS: EASIER has been launched in all 3 countries. …”
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146343por Usmani, Omar, Li, Grace, De Backer, Jan, Sadafi, Hosein, Wu, Libo, Marshall, Jonathan“…Further research is needed to understand if the enhanced delivery of BGF translates to clinical benefits. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12931-023-02534-y.…”
Publicado 2023
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146344por Sleiman, Yvonne, Reiken, Steven, Charrabi, Azzouz, Jaffré, Fabrice, Sittenfeld, Leah R., Pasquié, Jean-Luc, Colombani, Sarah, Lerman, Bruce B., Chen, Shuibing, Marks, Andrew R., Cheung, Jim W., Evans, Todd, Lacampagne, Alain, Meli, Albano C.“…In contrast with the 3 other drugs, S107 was able to prevent a major post-translational modification of RyR2-H29D mutant channels, the loss of calstabin2 binding to RyR2. …”
Publicado 2023
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146345por Maes, Margaret E., Donahue, Ryan J., Schlamp, Cassandra L., Marola, Olivia J., Libby, Richard T., Nickells, Robert W.“…CONCLUSIONS: A comparison between BAX activation kinetics in tissue culture cells and in cells of a complex tissue environment shows distinct differences indicating that caution should be used when translating findings from one condition to the other. …”
Publicado 2023
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146346por Symon, Andrew, Lightly, Kate, Howard, Rachel, Mundle, Shuchita, Faragher, Brian, Hanley, Molly, Durocher, Jill, Winikoff, Beverly, Weeks, Andrew“…Forms were completed on paper in the local language or in English, supported by Research Assistants. Following translation (when needed), responses were uploaded to a REDCap database, coded in Excel and analysed thematically. …”
Publicado 2023
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146347por Suhana, Panaparambil Azis, Kusum, Lata, Shruti, Jain Vij, Sreekanth, Gopinathan Pillai, Bijukumar, Damodaran, Shaji Kumar, R T, Muraleedharan, K C, Kaushik, Subhash“…The immunological assays will be conducted at the Department of Biotechnology-Translational Health Science and Technology Institute, Faridabad, India. …”
Publicado 2023
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146348por Bond, Dale S, Papasavas, Pavlos K, Raynor, Hollie A, Grilo, Carlos M, Steele, Vaughn R“…If successful, the results would provide a rationale for a fully powered trial to examine whether rTMS-related changes in food reinforcement translate into healthier eating patterns and improved MBS outcomes. …”
Publicado 2023
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146349por Peiris, David P, Joshi, Rohina, Webster, Ruth J, Groenestein, Patrick, Usherwood, Tim P, Heeley, Emma, Turnbull, Fiona M, Lipman, Alexandra, Patel, Anushka A“…BACKGROUND: Challenges remain in translating the well-established evidence for management of cardiovascular disease (CVD) risk into clinical practice. …”
Publicado 2009
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146350por Archambault, Patrick Michel, Bilodeau, Andrea, Gagnon, Marie-Pierre, Aubin, Karine, Lavoie, André, Lapointe, Jean, Poitras, Julien, Croteau, Sylvain, Pham-Dinh, Martin, Légaré, France“…BACKGROUND: Wikis are knowledge translation tools that could help health professionals implement best practices in acute care. …”
Publicado 2012
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146351por Aubert, Olivier, Kamar, Nassim, Vernerey, Dewi, Viglietti, Denis, Martinez, Frank, Duong-Van-Huyen, Jean-Paul, Eladari, Dominique, Empana, Jean-Philippe, Rabant, Marion, Verine, Jerome, Rostaing, Lionel, Congy, Nicolas, Guilbeau-Frugier, Céline, Mourad, Georges, Garrigue, Valérie, Morelon, Emmanuel, Giral, Magali, Kessler, Michèle, Ladrière, Marc, Delahousse, Michel, Glotz, Denis, Legendre, Christophe, Jouven, Xavier, Lefaucheur, Carmen, Loupy, Alexandre“…This strategy achieved ECD graft survival comparable to that of patients receiving an SCD transplant overall, translating to a 544.6 allograft life years saved during the nine years of study inclusion time. …”
Publicado 2015
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146352por Partridge, Stephanie R, Balestracci, Kate, Wong, Annette TY, Hebden, Lana, McGeechan, Kevin, Denney-Wilson, Elizabeth, Harris, Mark F, Phongsavan, Philayrath, Bauman, Adrian, Allman-Farinelli, Margaret“…This study is an important contribution for future research into efficacy, translation, and implementation of cost-effective programs for the prevention of weight gain in young adults. …”
Publicado 2015
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146353por Jun, Gyungah, Ibrahim-Verbaas, Carla A., Vronskaya, Maria, Lambert, Jean-Charles, Chung, Jaeyoon, Naj, Adam C., Kunkle, Brian W., Wang, Li-San, Bis, Joshua C., Bellenguez, Céline, Harold, Denise, Lunetta, Kathryn L., Destefano, Anita L., Grenier-Boley, Benjamin, Sims, Rebecca, Beecham, Gary W., Smith, Albert V., Chouraki, Vincent, Hamilton-Nelson, Kara L., Ikram, M. Arfan, Fievet, Nathalie, Denning, Nicola, Martin, Eden R., Schmidt, Helena, Kamatani, Yochiro, Dunstan, Melanie L, Valladares, Otto, Laza, Agustin Ruiz, Zelenika, Diana, Ramirez, Alfredo, Foroud, Tatiana M., Choi, Seung-Hoan, Boland, Anne, Becker, Tim, Kukull, Walter A., van der Lee, Sven J., Pasquier, Florence, Cruchaga, Carlos, Beekly, Duane, Fitzpatrick, Annette L., Hanon, Oliver, Gill, Michael, Barber, Robert, Gudnason, Vilmundur, Campion, Dominique, Love, Seth, Bennett, David A., Amin, Najaf, Berr, Claudine, Tsolaki, Magda, Buxbaum, Joseph D., Lopez, Oscar L., Deramecourt, Vincent, Fox, Nick C, Cantwell, Laura B., Tárraga, Lluis, Dufouil, Carole, Hardy, John, Crane, Paul K., Eiriksdottir, Gudny, Hannequin, Didier, Clarke, Robert, Evans, Denis, Mosley, Thomas H., Letenneur, Luc, Brayne, Carol, Maier, Wolfgang, De Jager, Philip, Emilsson, Valur, Dartigues, Jean-François, Hampel, Harald, Kamboh, M. Ilyas, de Bruijn, Renee F.A.G., Tzourio, Christophe, Pastor, Pau, Larson, Eric B., Rotter, Jerome I., O’Donovan, Michael C, Montine, Thomas J., Nalls, Michael A., Mead, Simon, Reiman, Eric M., Jonsson, Palmi V., Holmes, Clive, St George-Hyslop, Peter H., Boada, Mercè, Passmore, Peter, Wendland, Jens R., Schmidt, Reinhold, Morgan, Kevin, Winslow, Ashley R., Powell, John F, Carasquillo, Minerva, Younkin, Steven G., Jakobsdóttir, Jóhanna, Kauwe, John SK, Wilhelmsen, Kirk C., Rujescu, Dan, Nöthen, Markus M, Hofman, Albert, Jones, Lesley, Haines, Jonathan L., Psaty, Bruce M., Van Broeckhoven, Christine, Holmans, Peter, Launer, Lenore J., Mayeux, Richard, Lathrop, Mark, Goate, Alison M., Escott-Price, Valentina, Seshadri, Sudha, Pericak-Vance, Margaret A., Amouyel, Philippe, Williams, Julie, van Duijn, Cornelia M., Schellenberg, Gerard D., Farrer, Lindsay A.“…Expression quantitative trait locus analysis revealed that rs113986870, one of the GWS SNPs near rs2732703, is significantly associated with four KANSL1 probes that target transcription of the first translated exon and an untranslated exon in hippocampus (P≤1.3x10(−8)), frontal cortex (P≤1.3x10(−9)), and temporal cortex (P≤1.2x10(−11)). …”
Publicado 2015
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146354por Ramsden, Christopher E, Zamora, Daisy, Majchrzak-Hong, Sharon, Faurot, Keturah R, Broste, Steven K, Frantz, Robert P, Davis, John M, Ringel, Amit, Suchindran, Chirayath M, Hibbeln, Joseph R“…Conclusions Available evidence from randomized controlled trials shows that replacement of saturated fat in the diet with linoleic acid effectively lowers serum cholesterol but does not support the hypothesis that this translates to a lower risk of death from coronary heart disease or all causes. …”
Publicado 2016
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146355por Buchholz, Susan Weber, Ingram, Diana, Wilbur, JoEllen, Fogg, Louis, Sandi, Giselle, Moss, Angela, Ocampo, Edith V“…Because Hispanic or Latino adults compose one-quarter of all adults employed in the food service industry, the Text4Walking team translated the physical activity text messages into Spanish. …”
Publicado 2016
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146356por Ito, Hiromi, Ichiyanagi, Osamu, Naito, Sei, Bilim, Vladimir N., Tomita, Yoshihiko, Kato, Tomoyuki, Nagaoka, Akira, Tsuchiya, Norihiko“…The aim of this study was to evaluate the role of GSK-3 in the PI3K/Akt/mTORC1 pathway and regulation of the downstream substrates, eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1), ribosomal protein S6 kinase (S6K), and ribosomal protein S6 (S6RP). …”
Publicado 2016
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146357por Kurth, Ann E, Chhun, Nok, Cleland, Charles M, Crespo-Fierro, Michele, Parés-Avila, José A, Lizcano, John A, Norman, Robert G, Shedlin, Michele G, Johnston, Barbara E, Sharp, Victoria L“…It was able to provide evidence-based, linguistically appropriate ART adherence support without requiring additional staff time, bilingual status, or translation services. We found that language preferences and cultural acceptability of a computer-based counseling tool exist on a continuum in our urban Spanish-speaking population. …”
Publicado 2016
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146358por Caponigro, Francesco, Di Gennaro, Elena, Ionna, Franco, Longo, Francesco, Aversa, Corrado, Pavone, Ettore, Maglione, Maria Grazia, Di Marzo, Massimiliano, Muto, Paolo, Cavalcanti, Ernesta, Petrillo, Antonella, Sandomenico, Fabio, Maiolino, Piera, D’Aniello, Roberta, Botti, Gerardo, De Cecio, Rossella, Losito, Nunzia Simona, Scala, Stefania, Trotta, Annamaria, Zotti, Andrea Ilaria, Bruzzese, Francesca, Daponte, Antonio, Calogero, Ester, Montano, Massimo, Pontone, Monica, De Feo, Gianfranco, Perri, Francesco, Budillon, Alfredo“…Objectives of the translational study are the evaluation on tumor samples of markers of treatment efficacy/resistance (i.e. γH2AX, p21/WAF, RAD51, XRCC1, EGFR, p-EGFR, Ki-67) and specific markers of VPA HDAC inhibitory activity (histones and proteins acetylation, Histone deacetylase isoforms) as well as valproate test, histones and proteins acetylation of peripheral blood mononuclear cell, tested on blood samples at baseline and at different time points during treatment. …”
Publicado 2016
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146359por Li, Mi, Pu, Yunqiao, Yoo, Chang Geun, Gjersing, Erica, Decker, Stephen R., Doeppke, Crissa, Shollenberger, Todd, Tschaplinski, Timothy J., Engle, Nancy L., Sykes, Robert W., Davis, Mark F., Baxter, Holly L., Mazarei, Mitra, Fu, Chunxiang, Dixon, Richard A., Wang, Zeng-Yu, Neal Stewart, C., Ragauskas, Arthur J.“…This finding suggests that lignin down-regulation in lignocellulosic feedstock confers improved saccharification that translates from greenhouse to field trial and that lignin content and biomass accessibility are two significant factors for developing a reduced recalcitrance feedstock by genetic modification. …”
Publicado 2017
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146360por Gilis-Januszewska, Aleksandra, Lindström, Jaana, Tuomilehto, Jaakko, Piwońska-Solska, Beata, Topór-Mądry, Roman, Szybiński, Zbigniew, Peltonen, Markku, Schwarz, Peter E. H., Windak, Adam, Hubalewska-Dydejczyk, Alicja“…However, little is known about long term results of these translational studies. Therefore, the purpose of this study was to examine the maintenance of diabetes type 2 risk factor reduction achieved 1 year after intervention and during 3 year follow-up in primary health care setting in Poland. …”
Publicado 2017
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