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146401por Natunen, Teemu, Martiskainen, Henna, Marttinen, Mikael, Gabbouj, Sami, Koivisto, Hennariikka, Kemppainen, Susanna, Kaipainen, Satu, Takalo, Mari, Svobodová, Helena, Leppänen, Luukas, Kemiläinen, Benjam, Ryhänen, Simo, Kuulasmaa, Teemu, Rahunen, Eija, Juutinen, Sisko, Mäkinen, Petra, Miettinen, Pasi, Rauramaa, Tuomas, Pihlajamäki, Jussi, Haapasalo, Annakaisa, Leinonen, Ville, Tanila, Heikki, Hiltunen, Mikko“…To evaluate whether the mouse model-derived results translate to human patients, the effects of diabetic phenotype on microglial pathology were assessed in cortical biopsies of idiopathic normal pressure hydrocephalus (iNPH) patients encompassing β-amyloid pathology. …”
Publicado 2020
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146402por Cigrovski Berkovic, Maja, Bilic-Curcic, Ines, Bozek, Tomislav, Herman Mahecic, Davorka, Klobucar Majanovic, Sanja, Canecki-Varzic, Silvija, Andric, Jelena, Marusic, Srecko, Mrzljak, Anna“…AIM: To investigate whether the efficacy of GLP-1RA and SGLT-2i combination observed in randomized controlled trials translates into therapeutic benefits in the Croatian population during routine clinical practice and follow-up. …”
Publicado 2020
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146403por Koutsouleris, Nikolaos, Dwyer, Dominic B., Degenhardt, Franziska, Maj, Carlo, Urquijo-Castro, Maria Fernanda, Sanfelici, Rachele, Popovic, David, Oeztuerk, Oemer, Haas, Shalaila S., Weiske, Johanna, Ruef, Anne, Kambeitz-Ilankovic, Lana, Antonucci, Linda A., Neufang, Susanne, Schmidt-Kraepelin, Christian, Ruhrmann, Stephan, Penzel, Nora, Kambeitz, Joseph, Haidl, Theresa K., Rosen, Marlene, Chisholm, Katharine, Riecher-Rössler, Anita, Egloff, Laura, Schmidt, André, Andreou, Christina, Hietala, Jarmo, Schirmer, Timo, Romer, Georg, Walger, Petra, Franscini, Maurizia, Traber-Walker, Nina, Schimmelmann, Benno G., Flückiger, Rahel, Michel, Chantal, Rössler, Wulf, Borisov, Oleg, Krawitz, Peter M., Heekeren, Karsten, Buechler, Roman, Pantelis, Christos, Falkai, Peter, Salokangas, Raimo K. R., Lencer, Rebekka, Bertolino, Alessandro, Borgwardt, Stefan, Noethen, Markus, Brambilla, Paolo, Wood, Stephen J., Upthegrove, Rachel, Schultze-Lutter, Frauke, Theodoridou, Anastasia, Meisenzahl, Eva“…CONCLUSIONS AND RELEVANCE: These findings suggest that psychosis transition can be predicted in a broader risk spectrum by sequentially integrating algorithms’ and clinicians’ risk estimates. For clinical translation, the proposed workflow should undergo large-scale international validation.…”
Publicado 2020
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146404por Asbjørnsen, Rikke Aune, Wentzel, Jobke, Smedsrød, Mirjam Lien, Hjelmesæth, Jøran, Clark, Matthew M, Solberg Nes, Lise, Van Gemert-Pijnen, Julia E W C“…CONCLUSIONS: The process of translating end user values and needs into design elements or features of eHealth technologies is an important part of the design process. …”
Publicado 2020
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146405por Vinci, Christine, Brandon, Karen O, Kleinjan, Marloes, Hernandez, Laura M, Sawyer, Leslie E, Haneke, Jody, Sutton, Steven K, Brandon, Thomas H“…BACKGROUND: The recent widespread availability of augmented reality via smartphone offers an opportunity to translate cue exposure therapy for smoking cessation from the laboratory to the real world. …”
Publicado 2020
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146406por Sekandi, Juliet Nabbuye, Onuoha, Nicole Amara, Buregyeya, Esther, Zalwango, Sarah, Kaggwa, Patrick Evans, Nakkonde, Damalie, Kakaire, Robert, Atuyambe, Lynn, Whalen, Christopher C, Dobbin, Kevin K“…The intervention will consist of a smartphone app, a weekly internet subscription, translated text message reminders, and incentives for those who adhere. …”
Publicado 2021
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146407por Ye, Miaobo, Luo, Guiwen, Ye, Dexiao, She, Mengting, Sun, Ning, Lu, Yu-Jing, Zheng, Jie“…The target name was translated to gene name using the UniProt database and then the Chinese medicine-compound-target network was constructed. …”
Publicado 2021
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146408por Arnold, Jason W., Roach, Jeffery, Fabela, Salvador, Moorfield, Emily, Ding, Shengli, Blue, Eric, Dagher, Suzanne, Magness, Scott, Tamayo, Rita, Bruno-Barcena, Jose M., Azcarate-Peril, M. Andrea“…CONCLUSIONS: Dietary GOS modulated homeostasis of the aging gut by promoting changes in microbiome composition and host gene expression, which was translated into decreased intestinal permeability and increased mucus production. …”
Publicado 2021
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146409por Bird, M., McGillion, M., Chambers, E. M., Dix, J., Fajardo, C. J., Gilmour, M., Levesque, K., Lim, A., Mierdel, S., Ouellette, C., Polanski, A. N., Reaume, S. V., Whitmore, C., Carter, N.“…In the creative field of health innovation, which includes the design of healthcare products, systems (governance and organization mechanisms), and services (delivery mechanisms), a framework for both soliciting the needs of end-users and translating these needs into the design of health innovations is needed. …”
Publicado 2021
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146410por Quezada, Esteban, Cappelli, Claudio, Diaz, Iván, Jury, Nur, Wightman, Nicholas, Brown, Robert H., Montecino, Martín, van Zundert, Brigitte“…Three major molecular mechanisms have emerged to explain C9ALS/FTD disease mechanisms: (1) C9ORF72 loss-of-function through haploinsufficiency, (2) dipeptide repeat (DPR) proteins mediated toxicity by the translation of the repeat RNAs, and more controversial, (3) RNA-mediated toxicity by bidirectional transcription of the repeats that form intranuclear RNA foci. …”
Publicado 2021
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146411por Forbes, Harriet, Morton, Caroline E, Bacon, Seb, McDonald, Helen I, Minassian, Caroline, Brown, Jeremy P, Rentsch, Christopher T, Mathur, Rohini, Schultze, Anna, DeVito, Nicholas J, MacKenna, Brian, Hulme, William J, Croker, Richard, Walker, Alex J, Williamson, Elizabeth J, Bates, Chris, Mehrkar, Amir, Curtis, Helen J, Evans, David, Wing, Kevin, Inglesby, Peter, Drysdale, Henry, Wong, Angel Y S, Cockburn, Jonathan, McManus, Robert, Parry, John, Hester, Frank, Harper, Sam, Douglas, Ian J, Smeeth, Liam, Evans, Stephen J W, Bhaskaran, Krishnan, Eggo, Rosalind M, Goldacre, Ben, Tomlinson, Laurie A“…However, this did not translate into a materially increased risk of covid-19 mortality, and absolute increases in risk were small.…”
Publicado 2021
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146412“…The questionnaire was developed and tested in Hebrew and translated into six other languages: English, Arabic, Spanish, French, Italian, and Russian. …”
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146413por Roy, Christopher W., Heerfordt, John, Piccini, Davide, Rossi, Giulia, Pavon, Anna Giulia, Schwitter, Juerg, Stuber, Matthias“…This novel approach to respiratory self-navigation can derive 3D nonrigid motion estimations from an acquired 1D signal yielding statistically significant improvement in image sharpness relative to 1D translational correction as well as XD-GRASP reconstructions. …”
Publicado 2021
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146414“…This could support a more efficient translation into practice.…”
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146415por Milotta, Giorgia, Munoz, Camila, Kunze, Karl P., Neji, Radhouene, Figliozzi, Stefano, Chiribiri, Amedeo, Hajhosseiny, Reza, Masci, Pier Giorgio, Prieto, Claudia, Botnar, René M.“…Image navigators are acquired to correct both inversion recovery (IR)-prepared and reference volumes for 2D translational respiratory motion, enabling motion compensated PSIR reconstruction with 100% respiratory scan efficiency. …”
Publicado 2021
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146416por Xiao, Lixing, Zou, Guoying, Cheng, Rui, Wang, Pingping, Ma, Kexin, Cao, Huimin, Zhou, Wenyang, Jin, Xiyun, Xu, Zhaochun, Huang, Yan, Lin, Xiaoyu, Nie, Huan, Jiang, Qinghua“…More importantly, we highlight the critical role of these differential alternative splicing events in poor prognosis, and we believe in the potential for their further translation into targets for immunotherapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-08470-8.…”
Publicado 2021
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146417por Safarika, Asimina, Wacker, James W., Katsaros, Konstantinos, Solomonidi, Nicky, Giannikopoulos, George, Kotsaki, Antigone, Koutelidakis, Ioannis M., Coyle, Sabrina M., Cheng, Henry K., Liesenfeld, Oliver, Sweeney, Timothy E., Giamarellos-Bourboulis, Evangelos J.“…CONCLUSIONS: InSep demonstrated high accuracy for predicting the presence of both bacterial and viral infections in ED patients with suspected acute infections or suspected sepsis. When translated into a rapid, point-of-care test, InSep will provide ED physicians with actionable results supporting early informed treatment decisions to improve patient outcomes while upholding antimicrobial stewardship. …”
Publicado 2021
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146418por Schütz, Narayan, Saner, Hugo, Botros, Angela, Pais, Bruno, Santschi, Valérie, Buluschek, Philipp, Gatica-Perez, Daniel, Urwyler, Prabitha, Müri, René M, Nef, Tobias“…Association with self-reported health, evaluated by EuroQol visual analog scale (EQ-VAS) ratings, were quantitatively evaluated using individual linear mixed-effects models. Translation to objective, real-world health incidents was investigated through manual retrospective case-by-case analysis. …”
Publicado 2021
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146419por Mølmen, Knut Sindre, Hammarström, Daniel, Falch, Gunnar Slettaløkken, Grundtvig, Morten, Koll, Lise, Hanestadhaugen, Marita, Khan, Yusuf, Ahmad, Rafi, Malerbakken, Bente, Rødølen, Tore Jørgen, Lien, Roger, Rønnestad, Bent R., Raastad, Truls, Ellefsen, Stian“…In this study, we aimed to investigate the assumed negative effects of COPD for health- and muscle-related responsiveness to resistance training using a healthy control-based translational approach. METHODS: Subjects with COPD (n = 20, GOLD II-III, FEV(1predicted) 57 ± 11%, age 69 ± 5) and healthy controls (Healthy, n = 58, FEV(1predicted) 112 ± 16%, age 67 ± 4) conducted identical whole-body resistance training interventions for 13 weeks, consisting of two weekly supervised training sessions. …”
Publicado 2021
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146420por Archambault, Patrick, Turcotte, Stéphane, Smith, Pascal Y, Said Abasse, Kassim, Paquet, Catherine, Côté, André, Gomez, Dario, Khechine, Hager, Gagnon, Marie-Pierre, Tremblay, Melissa, Elazhary, Nicolas, Légaré, France“…These interventions will address the barriers to using wiki-based knowledge tools, find ways to ensure the quality of their content, foster contributions, and support the exploration of wiki-based knowledge tools as potential effective knowledge translation tools in trauma care.…”
Publicado 2021
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