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  1. 146501
    “…Assessment and treatment waiting times together with a lack of information regarding symptoms and treatment options translated into poor care experiences. The participants’ responses provide proof-of-concept support for the development of a digital mental health assessment app and valuable recommendations regarding desirable app features.…”
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    Opportunities for the Implementation of a Digital Mental Health Assessment Tool in the United Kingdom: Exploratory Survey Study
  2. 146502
    por Zhou, Chengzhi, Qin, Yinyin, Zhao, Wei, Liang, Zhenyu, Li, Min, Liu, Dan, Bai, Li, Chen, Yahong, Chen, Yan, Cheng, Yuan, Chu, Tianqing, Chu, Qian, Deng, Haiyi, Dong, Yuchao, Fang, Wenfeng, Fu, Xiuhua, Gao, Beili, Han, Yiping, He, Yong, Hong, Qunying, Hu, Jie, Hu, Yi, Jiang, Liyan, Jin, Yang, Lan, Fen, Li, Qiang, Li, Shuben, Li, Wen, Li, Yaqing, Liang, Wenhua, Lin, Gen, Lin, Xinqing, Liu, Ming, Liu, Xiaofang, Liu, Xiaoju, Liu, Zhefeng, Lv, Tangfeng, Mu, Chuanyong, Ouyang, Ming, Qin, Jianwen, Ren, Shengxiang, Shi, Huanzhong, Shi, Minhua, Su, Chunxia, Su, Jin, Sun, Dejun, Sun, Yongchang, Tang, Huaping, Wang, Huijuan, Wang, Kai, Wang, Ke, Wang, Mengzhao, Wang, Qi, Wang, Wei, Wang, Xiaoping, Wang, Yuehong, Wang, Zhijie, Wang, Zirui, Wu, Lin, Wu, Di, Xie, Baosong, Xie, Min, Xie, Xiaohong, Xie, Zhanhong, Xu, Shufeng, Xu, Xiaoman, Yang, Xia, Yin, Yan, Yu, Zongyang, Zhang, Jian, Zhang, Jianqing, Zhang, Jing, Zhang, Xiaoju, Zhang, Yingying, Zhong, Diansheng, Zhou, Qing, Zhou, Xiangdong, Zhou, Yanbin, Zhu, Bo, Zhu, Zhengfei, Zou, Chenxi, Zhong, Nanshan, He, Jianxing, Bai, Chunxue, Hu, Chengping, Li, Weimin, Song, Yong, Zhou, Jianying, Han, Baohui, Varga, Janos, Barreiro, Esther, Park, Hye Yun, Petrella, Francesco, Saito, Yuichi, Goto, Taichiro, Igai, Hitoshi, Bravaccini, Sara, Zanoni, Michele, Solli, Piergiorgio, Watanabe, Satoshi, Fiorelli, Alfonso, Nakada, Takeo, Ichiki, Yoshinobu, Berardi, Rossana, Tsoukalas, Nikolaos, Girard, Nicolas, Rossi, Antonio, Passaro, Antonio, Hida, Toyoaki, Li, Shiyue, Chen, Liang’an, Chen, Rongchang
    Publicado 2023
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    International expert consensus on diagnosis and treatment of lung cancer complicated by chronic obstructive pulmonary disease
  3. 146503
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    Impact of ramucirumab plus erlotinib on circulating cell-free DNA from patients with untreated metastatic non-small cell lung cancer with EGFR-activating mutations (RELAY phase 3 randomized study)
  4. 146504
    “…Further work on refining structures of the drugs, their distribution and clearance will be needed for progress towards bench-to-bedside clinical translation. ABSTRACT: Aquaporin (AQP) channels in endometrial cancer (EC) cells are of interest as pharmacological targets to reduce tumor progression. …”
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    Reducing the Invasiveness of Low- and High-Grade Endometrial Cancers in Both Primary Human Cancer Biopsies and Cell Lines by the Inhibition of Aquaporin-1 Channels
  5. 146505
    “…He spoke minimal English and was mostly accompanied by his family members who translated. He was an ex-smoker who was independent and worked in a shop. …”
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    P28 ESR – master of disguise in a case of rheumatoid arthritis
  6. 146506
    “…However, these changes did not translate into worse diabetes control and management in our cohort. …”
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    THU329 Healthcare Disparities In Diabetes Management During The COVID-19 Pandemic
  7. 146507
    “…In summary, the hALOX12 mouse model serves as a preclinical translational platform to interrogate effects of next generation 12-LOX inhibitors and demonstrates the potential of VLX-1005 to modify T1D disease progression. …”
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    SAT071 Inhibition Of 12 Lipoxygenase In A Humanized Mouse Model Of Type 1 Diabetes Delays Progression Of Hyperglycemia
  8. 146508
    “…If confirmed by longitudinal studies, these observations may translate to a greater risk for musculoskeletal derangements in later life stages. …”
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    THU632 Musculoskeletal Composition And Function In Polycystic Ovary Syndrome: Early Evidence From A Prospective Study
  9. 146509
    “…Also, AngII reduced the expression of Eukaryotic Translation Initiation Factor 4E Binding Protein 1 by 43% (P= 0.001) and increased expression of CAP-Gly Domain Containing Linker Protein 1 by 70% (P= 0.00003) - important signaling molecules that are downstream of mTOR activation. …”
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    FRI141 Dietary Salt Regulates mTORC1 Signaling In Humans And Mice With Hypertension
  10. 146510
    “…Methods: In total, 140 postmenopausal women with osteoporosis of the lumbar spine, followed at the Unit on Clinical and Translational Research in Endocrinology, University of Athens, Athens, Greece, were enrolled. …”
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    THU425 Brief, Low-impact, High-intensity Osteogenic Loading Training Utilizing Proprietary Osteostrong Devices With Once-A-Week, 10 Minute Treatments Improves Bone Mineral Density In Women With Osteoporosis Of The Lumbar Spine
  11. 146511
    “…Specifically, the weight gain (WG), feed conversion ratio (FCR), activity of alanine transaminase (ALT), growth hormone (GH), and insulin-like growth factor-1 (IGF-1) contents of serum, mRNA level of interleukin-10 (il-10), zonula occludens-2 (zo-2), claudin-3, claudin-12, and eukaryotic translation initiation factor 4G (eif4g) were significantly higher, and the activity of α-amylase (AMS), lipase (LPS) in the foregut and midgut, interleukin-8 (il-8) expression in the intestine was significantly lower than that in the CP80 group, compared with those in AP80 and PP80 groups (P < 0.05). …”
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    Terrestrial Compound Protein Replacing Dietary Fishmeal Improved Digestive Enzyme Activity, Immune Response, Intestinal Microflora Composition, and Protein Metabolism of Golden Pompano (Trachinotus ovatus)
  12. 146512
    “…Therefore, our findings have a great translational potential for improving outcomes in TNBC patients.…”
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    Immunotherapy Enhancement by Targeting Extracellular Tumor pH in Triple-Negative Breast Cancer Mouse Model
  13. 146513
    “…Forty-two patients (5.7%) experienced disease relapse during follow-up (9 local, 31 distant, 2 both), of which 9 were detected after 10 or more years. This translated into approximately 1 relapse detected for every 170 computed tomography scans performed, with a median radiation exposure of 80 (IQR, 32-112) mSv per patient. …”
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    Guideline-Based Follow-Up Outcomes in Patients With Gastrointestinal Stromal Tumor With Low Risk of Recurrence: A Report From the Italian Sarcoma Group
  14. 146514
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    Association between platelet-to-lymphocyte ratio and outcomes in HER2-positive advanced breast cancer patients treated with pyrotinib: a retrospective study
  15. 146515
    “…RESULTS: Relative to the conventional external high energy linacs, the uncertainty on overall reference dose in MR‐linac is more significantly affected by the chamber setup: A translational displacement along y ‐axis of ± 3 mm results in dose variation of < |0.20| ± 0.02% (k = 1), while rotation of ± 5° in horizontal and vertical parallel planes relative to relative to the direction of magnetic field, did not exceed variation of < |0.44| ± 0.02% for all 5 ionization chambers. …”
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    Quantifying uncertainties associated with reference dosimetry in an MR‐Linac
  16. 146516
    “…Further large-scale studies will help determine whether these promising results translate into improved clinical and oncological outcomes.…”
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    Comparison of the effects of high-intensity interval and moderate-intensity continuous training on inflammatory markers, cardiorespiratory fitness, and quality of life in breast cancer patients
  17. 146517
    “…Our findings suggest the larvicidal proteins are packaged into their respective compartments of the parasporal body during translation. Although the parasporal body is larger and more complex than the compartments formed by encapsulins, they both create distinct encased compartments within the bacterial cell, thereby functioning as bacterial organelles. …”
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    The Parasporal Body of Bacillus thuringiensis subsp. israelensis: A Unique Phage Capsid-Associated Prokaryotic Insecticidal Organelle
  18. 146518
    “…Murine models provide translational data that can provide insight into therapeutic alternatives, and assist in clinical guidance. …”
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    2798. Difficult to treat GES and KPC harboring Pseudomonas aeruginosa: Evaluation of in vivo efficacy of ß-lactam/ß-lactamase inhibitor humanized exposure vs. in vitro efficacy
  19. 146519
    “…To test if the in-vitro tolerance phenotype translated to decreased antibiotic efficacy in-vivo, we developed a murine model of E. coli bacteremia. …”
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    224. Clinical Relevance of Antibiotic Tolerance in Recurrent Gram-negative Bloodstream Infections
  20. 146520
    “…The data thus indicate that androgen ablation leads to translational upregulation of an endonucleolytic activity with properties identical to DNase I in rat ventral prostate, followed by its intracellular retention and final nuclear translocation in those epithelial cells that are destined to apoptotic elimination.…”
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    Androgen Ablation Leads to an Upregulation and Intranuclear Accumulation of Deoxyribonuclease I in Rat Prostate Epithelial Cells Paralleling Their Apoptotic Elimination
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