“…N-Glycosylation of proteins, an important post-translational modification in eukaryotic cells, plays an essential role in the regulation of cell adhesion, migration, signal transduction, and apoptosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…LIMITATIONS, REASONS FOR CAUTION: Patients from continents other than Europe were under-represented in this survey. A lack of translation of the survey might have limited the active participation of people in non-English speaking countries. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Depending on age and fibrosis stage, non–liver-related mortality was higher than liver-related mortality in patients with NAFLD. By translating surrogate markers into clinical outcomes, the NAFLD Simulator could be used as an educational tool among patients and clinicians to increase awareness of the health consequences of NAFLD.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Conclusion: Replacing Glu in the PSMA-targeting Lys-urea-Glu pharmacophore of [(68)Ga]Ga-HTK03041 with Asp and Aad generates [(68)Ga]Ga-HTK03161 and [(68)Ga]Ga-HTK03149, respectively, and the new derivatives retain high uptake in LNCaP tumors and have minimal uptake in normal organs/tissues including kidneys and salivary glands. [(177)Lu]Lu-HTK03149 also retain high uptake in LNCaP tumors and has minimal uptake in normal organs/tissues, and is, therefore, promising for clinical translation to treat prostate cancer.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…An effective way to reduce the severity of radiation-induced oral mucositis—thereby translating into reduced morbidity, treatment interruptions, and overall treatment time, which have been shown to impact prognosis favorably.…”
Enlace del recurso
Enlace del recurso

“…Seven genomic loci including internal transcribed spacer (ITS) region (n = 219), translational elongation factor (TEF 1-α) (n = 40), partial beta tubulin (BT) (n = 40), large ribosomal subunit (LSU) (n = 34), calmodulin (CAL) (n = 29), high mobility group transcription factor (HMG) (n = 17), and α-box (n = 17) were amplified by polymerase chain reaction (PCR). …”
Enlace del recurso
Enlace del recurso

“…More informative results may be gained by restricting the genomic search space a priori to a subset of genes that are likely to be related to a phenotype, and then zooming in to individual SNPs that are known/suspected to affect protein structure/function(1) or influence transcription/translation of the gene. Where the modes of regulation of a key gene are still not completely characterized despite decades of research, such as in CAP59, the presence of a phenotypically monitored, lone SNP in a strategic position within an almost SNP-less region can give potentially precious hints where otherwise none exist; we illustrate this strategy of SNP-focused local exploration for the promoter/enhancer and currently used MLST amplicon of CAP59. …”
Enlace del recurso
Enlace del recurso

“…Transcriptional activity of SF1 is regulated by post-translational modifications including phosphorylation (S203) and SUMOylation (K119 and K194). …”
Enlace del recurso
Enlace del recurso

“…CONCLUSION: Patients with NAFLD with advanced fibrosis showed significant differences in the apolipoproteomic composition of HDL particles, and this translated into increased cardiovascular risk based on pCAD index. …”
Enlace del recurso
Enlace del recurso

“…Although PDCD4 and PTEN mRNA expression remained unaffected, PDCD4 protein expression is inhibited cells was significantly increased (p=0.0233, n=4), suggesting a miR-21 role in PDCD4 translation. PTEN protein was unaffected by miR-21 inhibition.In further experiments, transfected cells were exposed to BPA, and apoptosis was examined. …”
Enlace del recurso
Enlace del recurso

“…These results demonstrate that with continued treatment, the potent GHR antagonist activity exhibited by AZP-3813 translates to sustained in vivo suppression of IGF1 levels and associated parameters, and support its development as a potential therapy for acromegaly. …”
Enlace del recurso
Enlace del recurso

“…Typically, association with ELAVL1 stabilize expression of target mRNAs, promoting their translation. Also, of interest is the role of the RBP ZFP36, which competes with ELAVL1 for binding to ARE's but has the opposing effect of directing mRNA to the degradation pathway. …”
Enlace del recurso
Enlace del recurso

“…The main mechanism of NICTH is tumoral overexpression of the IGF2 gene and aberrant post-translational processing, resulting in partially processed high-molecular-weight IGF2 (big-IGF2). …”
Enlace del recurso
Enlace del recurso

“…During the pandemic, we suggest developing a living guideline of which recommendations are supported by a systematic review for it can facilitate the timely translation of the latest research findings to clinical practice. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Dorsal subluxation/translation of first metatarsal at first TMT joint was observed 3 (15%) in radiograph and 9 (45%) in WBCT. …”
Enlace del recurso
Enlace del recurso

“…This situation has persisted, despite the wide implementation of several capacity building-oriented interventions including clinical mentoring for skilled birth attendants that were anticipated to translate in to high–quality maternal and newborn care on each encounter. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: This study demonstrated correction of midfoot abduction, translated by the TNCA, in the absence of lateral column lengthening procedures. …”
Enlace del recurso
Enlace del recurso

“…CATEGORY: Bunion; Midfoot/Forefoot INTRODUCTION/PURPOSE: The majority of hallux valgus corrections are performed via a two dimensional approach with 1st metatarsal osteotomy and translation in the transverse plane. This approach has demonstrated high long-term recurrence rates. …”
Enlace del recurso
Enlace del recurso

“…English Responses Readability: Avg FRE: Google (51.3 +/-12. 0), Alexa (71.1 +/- 9.9) (higher = easier reading) Avg FGL: Google (9.8 grade +/-1.7), Alexa (6.5 grade +/- 0.8) (higher = higher grade level) Avg SI: Google (9.5 +/-1.5), Alexa (6.5 +/-0.9) (higher = harder reading) Avg DCGL: Google (College), Alexa (Grades 9-10) Conclusion: Digital Voice Assistant Devices are helpful to patients who are visually impaired, have poor mobility or need language translation. Under physician guidance, these devices provide diabetes education for our patients and for the lay public. …”
Enlace del recurso
Enlace del recurso