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147061“…It is not clear whether better clinical outcomes derived from increasing statin adherence levels can be translated into cost savings and lower health care utilization. …”
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147062por Li, Qing, Zhao, Yujing, Guo, Hongyan, Li, Qiao, Yan, Chaoying, Li, Yansong, He, Shuxuan, Wang, Nan, Wang, Qiang“…Taken together, these findings uncover a previously unappreciated mechanism of impaired lipophagy-induced TREM1 accumulation in microglia and neuroinflammation in DACI, suggesting its translational potential as an attractive therapeutic target for delaying diabetes-associated cognitive decline. …”
Publicado 2023
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147063por Murphy, Christopher K, O’Donnell, Michelle M, Hegarty, James W, Schulz, Sarah, Hill, Colin, Ross, R Paul, Rea, Mary C, Farquhar, Ronald, Chesnel, Laurent“…In this study, we hypothesized that in vitro activities of ADS024 will translate in vivo to protect against CDI challenge in mouse models. …”
Publicado 2023
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147064por Figueres, Lucile, Takacs, Istvan, Mezosi, Emese, Soto, Alfonso, Kamenicky, Peter, Lemoine, Sandrine, Borson-Chazot, Francoise, Capel, Ismael, Angeles Artazcoz Galvez Moreno, Maria Angeles, Ovize, Michel, OuldRouis, Taha, Allas, Soraya, Sumeray, Mark, Mannstadt, Michael“…The observed significant improvement in both uCa and sP is expected to translate to a clinically meaningful benefit for cHP patients in the long-term. …”
Publicado 2023
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147065por Sampson Kjeldsen, Sasha Alexandra, Lotte Gluud, Lise, Werge, Mikkel, Steen Pedersen, Julie, Bendtsen, Flemming, Alexiadou, Kleopatra, Tan, Tricia, Torekov, Signe S, Iepsen, Eva W, Jensen, Nicole J, Richter, Michael, Hartmann, Bolette, Holst, Jens J, Holst, Birgitte, Holt, Joachim, Madsbad, Sten, Svane, Maria S, Bojsen-Møller, Kirstine N, Wewer Albrechtsen, Nicolai J“…There were no differences in plasma NEP protein between any of the comparator groups, suggesting that changes in NEPa in metabolic disease are post-translational modifications of the enzyme or other mechanisms influencing NEPa. …”
Publicado 2023
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147066por Hernández Guerrero, Tatiana, Baños, Natalia, del Puerto Nevado, Laura, Mahillo-Fernandez, Ignacio, Doger De-Speville, Bernard, Calvo, Emiliano, Wick, Michael, García-Foncillas, Jesús, Moreno, Victor“…ABSTRACT: Background: patient-derived xenografts (PDXs) have defined the field of translational cancer research in recent years, becoming one of the most-used tools in early drug development. …”
Publicado 2023
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147067por Epsi, Nusrat J, Richard, Stephanie A, Chenoweth, Josh, Lindholm, David, Mende, Katrin, Ganesan, Anuradha, Huprikar, Nikhil, Lalani, Tahaniyat, Smith, Alfred, Mody, Rupal, Schofield, Christina, Colombo, Rhonda E, Flanagan, Ryan, Ewers, Evan, Berjohn, Catherine, Saunders, David, Jones, Milissa, Edwards, Margaret, Simons, Mark P, O’Connell, Robert, Tribble, David R, Tribble, David R, Agan, Brian, Burgess, Timothy, Dalgard, Clifton, Pollett, Simon“…CONCLUSION: Our study demonstrates the potential of using machine learning to translate transcriptomic data into precision medicine applications, specifically for predicting the development of PCC after COVID-19. …”
Publicado 2023
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147068por Charles, Reema, Milani, Barbara, Dagne, Daniel Argaw, Ali, Bisma, Stone, Heather, Schito, Marco, Tirupathi, Raghavendra, Oliver, Nalini“…CURE ID, a web-based repository developed by the FDA and the National Center for Advancing Translational Sciences (NCATS) to gather real-world data (RWD) on the novel uses of existing drugs for difficult-to-treat infectious diseases. …”
Publicado 2023
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147069por Sivamani, Raja K, Pullar, Christine E, Manabat-Hidalgo, Catherine G, Rocke, David M, Carlsen, Richard C, Greenhalgh, David G, Isseroff, R. Rivkah“…This work suggests that specific β2AR antagonists may be apt, near-term translational therapeutic targets for enhancing burn wound healing, and may provide a novel, low-cost, safe approach to improving skin wound repair in the stressed individual.…”
Publicado 2009
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147070por Chalfie, Martin“…Though there has been a recent push for clinically-relevant or patent-producing (translational) research, Chalfie warns that taking this approach alone is a mistake, given how "woefully little" we know about biology. …”
Publicado 2010
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147071por Wang, Guoqing, Xu, Zhibo, Wang, Rui, Al-Hijji, Mohammed, Salit, Jacqueline, Strulovici-Barel, Yael, Tilley, Ann E, Mezey, Jason G, Crystal, Ronald G“…Based on the literature, genes in the up-regulated list were used to identify a 73 “MUC5AC-associated core gene” list with 9 categories: mucus component; mucus-producing cell differentiation-related transcription factor; mucus-producing cell differentiation-related pathway or mediator; post-translational modification of mucin; vesicle transport; endoplasmic reticulum stress-related; secretory granule-associated; mucus secretion-related regulator and mucus hypersecretory-related ion channel. …”
Publicado 2012
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147072por Cook, Carly N, Mascia, Michael B, Schwartz, Mark W, Possingham, Hugh P, Fuller, Richard A“…Although these are not the only approaches to generating boundary-spanning science, nor are they mutually exclusive, they provide mechanisms for promoting communication, translation, and mediation across the knowledge–action boundary. …”
Publicado 2013
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147073por Majewski, Marek, Sarosiek, Irene, Wallner, Grzegorz, Edlavitch, Stanley A, Sarosiek, JerzyEnlace del recurso
Publicado 2014
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147076por Plaisance, Ariane, Witteman, Holly O, Heyland, Daren Keith, Ebell, Mark H, Dupuis, Audrey, Lavoie-Bérard, Carole-Anne, Légaré, France, Archambault, Patrick Michel“…In the second phase of the study, we will build a first prototype based on the needs identified in Phase I. We will start by translating an existing DA entitled “Cardiopulmonary resuscitation: a decision aid for patients and their families.” …”
Publicado 2016
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147079por Li, Jiale, Zhou, Ping, Li, Lan, Zhang, Yan, Shao, Yang, Tang, Li, Tian, Shuangming“…Our study demonstrated a potential strategy that could be translated clinically to improve liver tumor gene delivery.…”
Publicado 2016
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147080por Losurdo, Giuseppe, Giorgio, Floriana, Piscitelli, Domenico, Montenegro, Lucia, Covelli, Claudia, Fiore, Maria Grazia, Giangaspero, Antonio, Iannone, Andrea, Principi, Mariabeatrice, Amoruso, Annacinzia, Barone, Michele, Di Leo, Alfredo, Ierardi, Enzo“…Therefore, the results of the present paper do not seem to show a clear translational value.…”
Publicado 2016
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