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1881por Araujo, Patricia R., Yoon, Kihoon, Ko, Daijin, Smith, Andrew D., Qiao, Mei, Suresh, Uthra, Burns, Suzanne C., Penalva, Luiz O. F.“…Translation regulation plays important roles in both normal physiological conditions and diseases states. …”
Publicado 2012
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1882“…Much of our knowledge on the roles of intra-axonal translation derives from the characterization of a small number of individual mRNAs that were found to be localized in axons. …”
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1883“…Recent studies revealed a novel eIF4E-interacting protein, involved in directing stage-specific and stress-induced translation pathways. Translation regulation during stress also follows unusual regulatory cues, as the increased translation of Hsp83 following heat stress is driven by a defined element in the 3′ UTR, unlike higher eukaryotes. …”
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1884“…BACKGROUND: A growing body of work on knowledge translation (KT) reveals significant gaps between what is known to improve health, and what is done to improve health. …”
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1885por Fabbretti, Attilio, Brandi, Letizia, Milón, Pohl, Spurio, Roberto, Pon, Cynthia L., Gualerzi, Claudio O.“…Translation initiation factor IF2 is a guanine nucleotide-binding protein. …”
Publicado 2012
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1886“…This article discusses the ongoing challenges translational researchers face and outlines recent initiatives to tackle these including the new changes to translational funding schemes proposed by the NIH and the MRC and the launch of the “European Advanced Translational Research InfraStructure in Medicine” (EATRIS). …”
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1887por Helmy, Karim, Halliday, John, Fomchenko, Elena, Setty, Manu, Pitter, Ken, Hafemeister, Christoph, Holland, Eric C.“…Post-transcriptional regulation of gene expression contributes to the protein output of a cell, however, methods for measuring translational regulation in complex in vivo systems are lacking. …”
Publicado 2012
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1888por Chen, Limo, Aktas, Bertal H, Wang, Yibo, He, Xiaoying, Sahoo, Rupam, Zhang, Nancy, Denoyelle, Severine, Kabha, Eihab, Yang, Hongwei, Freedman, Revital Yefidoff, Supko, Jeffrey G, Chorev, Michael, Wagner, Gerhard, Halperin, Jose A“…Translation initiation factors are over-expressed and/or activated in many human cancers and may contribute to their genesis and/or progression. …”
Publicado 2012
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1894por Rapoport, Mark J.Enlace del recurso
Publicado 2012
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1896por Sevick-Muraca, Eva M., Akers, Walter J., Joshi, Bishnu P., Luker, Gary D., Cutler, Cathy S., Marnett, Lawrence J., Contag, Christopher H., Wang, Thomas D., Azhdarinia, Ali“…Herein, we propose a navigational approach (as opposed to a fixed “roadmap”) for translation of optical imaging agents that is (i) proposed through consensus by four academic research programs that are part of the cooperative U54 NCI Network for Translational Research, (ii) developed through early experiences for translating optical imaging agents in order to meet distinctly varied needs in cancer diagnostics, and (iii) adaptable to the rapidly changing environment of academic medicine. …”
Publicado 2012
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1897por Gregory, Martin H., Capito, Nicholas, Kuroki, Keiichi, Stoker, Aaron M., Cook, James L., Sherman, Seth L.“…Knee osteoarthritis remains a tremendous public health concern, both in terms of health-related quality of life and financial burden of disease. Translational research is a critical step towards understanding and mitigating the long-term effects of this disease process. …”
Publicado 2012
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1898“…Here, we present a qualitative model to simulate the effect of an sRNA on the translation initiation of a potential target. Information about the ribosome–mRNA interaction, sRNA–mRNA interaction and expression information from deep sequencing experiments is integrated to calculate the change in translation initiation complex formation, as a proxy for translational activity. …”
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1899
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1900“…In this review, we summarize the modifications that inhibit the activity of the main canonical translation initiation factors, and the data explaining how certain mRNAs encoding proteins involved in either cell survival or apoptosis can be selectively translated.…”
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