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481por Desrosiers, Jean-Nicolas, Wei, Xudong, Gutierrez, Osvaldo, Savoie, Jolaine, Qu, Bo, Zeng, Xingzhong, Lee, Heewon, Grinberg, Nelu, Haddad, Nizar, Yee, Nathan K., Roschangar, Frank, Song, Jinhua J., Kozlowski, Marisa C., Senanayake, Chris H.“…The direct arylation of pyridine substrates using non-precious catalysts is underdeveloped but highly desirable due to its efficiency to access important motifs while being extremely cost-effective. …”
Publicado 2016
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482“…Given the numerous essential proteins in the bacterial replisome that may serve as a potential target for inhibitors and the relative paucity of suitable compounds, it is evident that antimicrobials targeting the replisome are underdeveloped so far. In this review, we report on the diversity of antimicrobial compounds targeting DNA replication and highlight some of the challenges in developing new drugs that target this process.…”
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483por Villegente, Matthieu, Marmey, Philippe, Job, Claudette, Galland, Marc, Cueff, Gwendal, Godin, Béatrice, Rajjou, Loïc, Balliau, Thierry, Zivy, Michel, Fogliani, Bruno, Sarramegna-Burtet, Valérie, Job, Dominique“…The role of these proteins is discussed in terms of protein evolution and physiological properties of the rudimentary, underdeveloped, Amborella embryos, notably considering that the acquisition of desiccation tolerance corresponds to the final developmental stage of mature seeds possessing large embryos.…”
Publicado 2017
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484“…Here, we review the various techniques, safety and efficacy of MSICS, and its progress and utility in developing and underdeveloped countries.…”
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485“…Snakebite primarily affects rural subsistent farming populations in underdeveloped and developing nations. The annual number of deaths (100,000) and physical disabilities (400,000) of snakebite victims is a societal tragedy that poses a significant added socioeconomic burden to the society. …”
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486“…In comparison, their application in catalysis has been underdeveloped. Relying on the rapid development of different algorithms and their implementation, it is the right timing to harvest the potential of ML in catalysis across academy and industry spectra. …”
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487“…A survey in the Central Highlands of Vietnam revealed a turmeric growing area showing serious disease symptoms, including stunting of the plant, yellowing or darkening of the leaf margins and tips, and underdeveloped dry and rotten rhizomes. An inspection for plant pathogens in soil samples from this area revealed a high density and frequency of Rotylenchus reniformis, with a significant relationship between the density of R. reniformis, rhizome weight, and level of plant damage. …”
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488por ONO, Tetsushi, HISAEDA, Keiichi, INOUE, Yoichi, YAMADA, Yutaka, SHIBANO, Kenichi, MITSUI, Ikki, HENMI, Chizuka, UNE, Yumi, HAYASHI, Hideaki, ROH, Sanggun, NOHARA, Masakatsu, UCHIDA, Eiji, NAGAHATA, Hajime“…The cellulae and cristae reticuli were underdeveloped; the cristae were 0.4–0.7 cm in height and milky white. …”
Publicado 2021
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489“…The last three decades have seen a significant increase in the number of reports of f-element carbon chemistry, whilst the f-element chemistry of silicon, germanium, tin, and lead remain underdeveloped in comparison. Here, in this perspective we review complexes that contain chemical bonds between f-elements and silicon or the heavier tetrels since the birth of this field in 1985 to present day, with the intention of inspiring researchers to contribute to its development and explore the opportunities that it presents. …”
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490“…Among the carbo-difunctionalization of alkynes, the stereoselective dialkylation of alkynes is the most challenging transformation due to associated competitive side reactions and thus remains underdeveloped. Herein, we report the first Ni-catalyzed regio- and trans-selective cross-dialkylation of alkynes with two distinct alkyl bromides to afford olefins with two aliphatic substituents. …”
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491por Wang, Yulei, Simon, Hendrik, Chen, Xinran, Lin, Zhipeng, Chen, Shan, Ackermann, Lutz“…While electrochemical ortho‐selective C−H activations are well established, distal C−H activations continue to be underdeveloped. In contrast, we herein describe the electrochemical meta‐C−H functionalization. …”
Publicado 2022
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492“…In sharp contrast, direct electrocatalytic transformations of weakly‐coordinating phenols remain underdeveloped. Herein, electrooxidative peri C−H alkenylations of challenging 1‐naphthols were achieved by versatile rhodium(III) catalysis via user‐friendly constant current electrolysis. …”
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493por Garrido Ruiz, Diego, Sandoval-Perez, Angelica, Rangarajan, Amith Vikram, Gunderson, Emma L., Jacobson, Matthew P.“…A review of current computational approaches suggests underdeveloped areas of research for studying cysteine reactivity through molecular simulations.…”
Publicado 2022
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494por Bai, Ziqian, Zhu, Shiyang, Hu, Yiyao, Yang, Peng, Chu, Xin, He, Gang, Wang, Hao, Chen, Gong“…Despite their widespread applications, the synthesis of sulfenamides, which feature S–N bonds that may be cleaved under mild conditions, remains underdeveloped. Here, we report a method for synthesis of N-acyl sulfenamides via copper-catalyzed nitrene-mediated S-amidation reaction of thiols with dioxazolones. …”
Publicado 2022
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495por Bilal, Hazrat, Zhang, Dongxing, Shafiq, Muhammad, Khan, Muhammad Nadeem, chen, Canhua, Khan, Sabir, Wang, Qian, Cai, Lin, Islam, Rehmat, Hu, Haibin, Zeng, Yuebin“…However, such epidemiological data are still lacking in underdeveloped regions of China. A retrospective analysis (2016 to 2021) was conducted in Meizhou People’s Hospital, China to study the burden of candidiasis, particularly candidemia, and antifungal susceptibilities of the species among hospitalized patients. …”
Publicado 2023
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496“…In fact, it may widen the existing gap for access to health between high and low income earners in these underdeveloped regions.…”
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497“…Formal cultural competence training in General Practice appeared to be underdeveloped despite GP registrars generally desiring more training. …”
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498“…What is often missing in the underdeveloped world is psychological support and a clear understanding by the athlete of his/her rehabilitation protocols. …”
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499por Penuelas, Josep, Krisztin, Tamás, Obersteiner, Michael, Huber, Florian, Winner, Hannes, Janssens, Ivan A., Ciais, Philippe, Sardans, Jordi“…Third, the consumption of alcoholic beverages correlates with prevalence and mortality by malignant neoplasms. Fourth, in underdeveloped countries, reducing famine has a greater positive impact on health and LE than a healthier diet.…”
Publicado 2020
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500por Muñoz, César, Guevara, Lissette, Escamilla, María-Isabel, Regino, Ronald, Acevedo, Nathalie, Escamilla-Arrieta, Jose Miguel“…Introduction: The severity of wheezing episodes is related with the need for health services, but the factors associated with health care utilization in preschool recurrent wheezers in underdeveloped regions are unclear. Objective: To evaluate the factors associated with health care utilization in preschool recurrent wheezers in Cartagena, Colombia. …”
Publicado 2021
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