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  1. 721
    “…Much important biochemistry derives from electrophilic enzyme cofactors, transient intermediates, and labile regulatory modifications, but ABPP probes for such species are underdeveloped. Here, we describe a versatile class of probes for this less charted hemisphere of the proteome. …”
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    Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets
  2. 722
    “…Children are predisposed to injuries of the upper cervical spine given their relatively immature osteology, ligamentous laxity, underdeveloped musculature, and larger ratios of head to body mass. …”
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    Temporary Internal Bracing for Pediatric Odontoid Synchondrosis Fracture
  3. 723
    “…We report what is, to the best of our knowledge, the first case of melioidosis diagnosed and treated in Bihar, an economically underdeveloped state in East India. The patient, a 52-year-old diabetic male, presented to the outpatient department with a fever of insidious onset along with pain and restriction of movement in the right shoulder joint and right knee joint, and swelling and tenderness of bilateral ankle joints. …”
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    Melioidosis in Bihar, India: unearthing the first of many?
  4. 724
    “…While ssNMR has shown significant progress in structural studies of proteins, the number of RNA studies remains limited due to ssNMR methodology that is still underdeveloped. Resonance assignment is the most critical and limiting step in the structure determination protocol that defines the feasibility of NMR studies. …”
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    Strategies for RNA Resonance Assignment by (13)C/(15)N- and (1)H-Detected Solid-State NMR Spectroscopy
  5. 725
    por Gold, Kaitlin M.
    Publicado 2021
    “…Despite its revolutionary potential, plant disease sensing remains an underdeveloped discipline, with challenges facing both fundamental study and field application. …”
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    Plant Disease Sensing: Studying Plant-Pathogen Interactions at Scale
  6. 726
    por de Lorenzo, Víctor
    Publicado 2021
    “…Our epoch is largely characterized by the growing realization and concern about the reality of climate change and environmental deterioration, the surge of global pandemics, the unacceptable inequalities between developed and underdeveloped countries and their unavoidable translation into messy immigration, overpopulation and food crises. …”
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    15 years of microbial biotechnology: the time has come to think big—and act soon
  7. 727
    “…The Brazilian long-term care (LTC) sector remains poorly structured and underdeveloped. COVID-19 did not bring unprecedented focus to the sector just because of the high mortality; it also affected the quality of care. …”
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    Perspectives Toward Long-Term Care Measurement From Frontline Workers in Brazil
  8. 728
    por Lepore, Michael, Corazzini, Kirsten
    Publicado 2021
    “…Measuring what matters most to residents, relatives and staff in residential long-term care settings is critical, yet underdeveloped in our predominantly frailty and deficits-focused measurement frameworks. …”
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    Measuring What Matters Across International Long-Term Care Settings
  9. 729
    “…Egg protein has been shown to decrease malnutrition in underdeveloped countries, possibly increase height in children, and protect against kwashiorkor. …”
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    The Health Benefits of Egg Protein
  10. 730
    “…Extremely preterm neonates are at risk of morbidity and mortality related to their underdeveloped skin barrier. Humidified incubators are typically used in their care, but there is a paucity of literature to inform the standardization of specific evidence-based humidification practices in the NICU. …”
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    Humidification Practices of Extremely Preterm Neonates: A Clinical Survey
  11. 731
    “…The patient presented with primary amenorrhea, underdeveloped secondary sexual characteristics, hypertension and hypokalemia. …”
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    A rare case of 17α-hydroxylase/17, 20-lyase deficiency: Clinical and genetic findings and follow-up outcomes
  12. 732
    “…Although many elegant methods have been developed to access BCP amines and BCP aryls efficiently, the methods used to construct BCP ketones directly are relatively underdeveloped. In particular, the preparation of unsymmetrical 1,3-disubstituted-BCP ketones remains challenging and still requires multiple chemical steps. …”
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    One step synthesis of unsymmetrical 1,3-disubstituted BCP ketones via nickel/photoredox-catalyzed [1.1.1]propellane multicomponent dicarbofunctionalization
  13. 733
    “…However, its complex structure and the underdeveloped technologies for its large-scale processing keep it in a state of constant study trying to establish a consolidated process. …”
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    Surfactants, Biosurfactants, and Non-Catalytic Proteins as Key Molecules to Enhance Enzymatic Hydrolysis of Lignocellulosic Biomass
  14. 734
    “…Despite the harmful effects of plastic accumulation in the environment, bioplastic production is still underdeveloped. Recent advances in strain development, genome sequencing, and editing technologies have accelerated research efforts toward bioplastic production and helped to advance its goal of replacing conventional plastics. …”
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    Closing the Gap between Bio-Based and Petroleum-Based Plastic through Bioengineering
  15. 735
    por He, Rong li, Liu, Yun, Tan, Quanhui, Wang, Lan
    Publicado 2023
    “…Methods: At present, tuberculosis is still a worldwide infectious disease that seriously threatens human health, especially in underdeveloped and developing countries. China is the largest developing country in the world with a large population. …”
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    The rare manifestations in tuberculous meningoencephalitis: a review of available literature
  16. 736
    “…Despite the blossoming of reports of diastereodivergent synthesis over the past years, switchable control of the stereochemistry of the bridgehead atoms of the fused frameworks has been significantly underdeveloped. Here we disclose the ability of Pd(0)-π-Lewis base catalysis to finely reverse the concerted inverse-electron-demand aza-Diels–Alder cycloaddition reaction between cyclic 1,3-dienes and aurone-derived 1-azadienes. …”
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    Diastereodivergent cis- and trans-fused [4 + 2] annulations of cyclic 1,3-dienes and 1-azadienes via ligand-controlled palladium catalysis
  17. 737
    por Rani, Prerna, Dhok, Archana
    Publicado 2023
    “…Stunting and its related health and developmental effects are particularly common in populations living in underdeveloped countries or those exposed to high levels of particle pollution. …”
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    Effects of Pollution on Pregnancy and Infants
  18. 738
    “…It is defined as a small (axial length ⩾2 standard deviations below the age-adjusted mean) underdeveloped eye, caused by disruption of ocular development through genetic or environmental factors in the first trimester of pregnancy. …”
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    Animal and cellular models of microphthalmia
  19. 739
    por Müller, Fernando, Wehbe, Luis
    Publicado 2008
    “…Tobacco smoking is a growing problem throughout Latin American countries, especially in underdeveloped countries where poverty and lack of education about the dangers of smoking may make people more susceptible to becoming smokers. …”
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    Smoking and smoking cessation in Latin America: a review of the current situation and available treatments
  20. 740
    “…However, RDS data are unique and require specialized analysis techniques, many of which remain underdeveloped. RDS sample size estimation requires knowing design effect (DE), which can only be calculated post hoc. …”
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    Estimating Design Effect and Calculating Sample Size for Respondent-Driven Sampling Studies of Injection Drug Users in the United States
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