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  1. 15921
    por Muzzarelli, Riccardo A. A.
    Publicado 2010
    “…Chitins and modified chitins exert a number of beneficial actions, i.e., (i) they stimulate macrophages by interacting with receptors on the macrophage surface that mediate the internalization of chitin particles to be degraded by lysozyme and N-acetyl-β-glucosaminidase (such as Nod-like, Toll-like, lectin, Dectin-1, leukotriene 134 and mannose receptors); (ii) the macrophages produce cytokines and other compounds that confer non-specific host resistance against bacterial and viral infections, and anti-tumor activity; (iii) chitin is a strong Th1 adjuvant that up-regulates Th1 immunity induced by heat-killed Mycobacterium bovis, while down- regulating Th2 immunity induced by mycobacterial protein; (iv) direct intranasal application of chitin microparticles into the lung was also able to significantly down-regulate allergic response to Dermatophagoids pteronyssinus and Aspergillus fumigatus in a murine model of allergy; (v) chitin microparticles had a beneficial effect in preventing and treating histopathologic changes in the airways of asthmatic mice; (vi) authors support the fact that chitin depresses the development of adaptive type 2 allergic responses. …”
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    Chitins and Chitosans as Immunoadjuvants and Non-Allergenic Drug Carriers
  2. 15922
    “…These included: i) who has done/is doing research in Solomon Islands (largely non-Solomon Islanders); ii) when the research was done (research needs to keep up to date); iii) amount of published research (there should be more); iv) types of research (lack of intervention and operational research); v) value of published research (important); vi) gaps in published literature (need more research about nursing); vii) opportunities for research action (start small); viii) support required to undertake research at the hospital and in surrounding communities (mentoring and partnering with experienced researchers). …”
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    "We can move forward": challenging historical inequity in public health research in Solomon Islands
  3. 15923
    por Pedrosa, Fábio O., Monteiro, Rose Adele, Wassem, Roseli, Cruz, Leonardo M., Ayub, Ricardo A., Colauto, Nelson B., Fernandez, Maria Aparecida, Fungaro, Maria Helena P., Grisard, Edmundo C., Hungria, Mariangela, Madeira, Humberto M. F., Nodari, Rubens O., Osaku, Clarice A., Petzl-Erler, Maria Luiza, Terenzi, Hernán, Vieira, Luiz G. E., Steffens, Maria Berenice R., Weiss, Vinicius A., Pereira, Luiz F. P., Almeida, Marina I. M., Alves, Lysangela R., Marin, Anelis, Araujo, Luiza Maria, Balsanelli, Eduardo, Baura, Valter A., Chubatsu, Leda S., Faoro, Helisson, Favetti, Augusto, Friedermann, Geraldo, Glienke, Chirlei, Karp, Susan, Kava-Cordeiro, Vanessa, Raittz, Roberto T., Ramos, Humberto J. O., Ribeiro, Enilze Maria S. F., Rigo, Liu Un, Rocha, Saul N., Schwab, Stefan, Silva, Anilda G., Souza, Eliel M., Tadra-Sfeir, Michelle Z., Torres, Rodrigo A., Dabul, Audrei N. G., Soares, Maria Albertina M., Gasques, Luciano S., Gimenes, Ciela C. T., Valle, Juliana S., Ciferri, Ricardo R., Correa, Luiz C., Murace, Norma K., Pamphile, João A., Patussi, Eliana Valéria, Prioli, Alberto J., Prioli, Sonia Maria A., Rocha, Carmem Lúcia M. S. C., Arantes, Olívia Márcia N., Furlaneto, Márcia Cristina, Godoy, Leandro P., Oliveira, Carlos E. C., Satori, Daniele, Vilas-Boas, Laurival A., Watanabe, Maria Angélica E., Dambros, Bibiana Paula, Guerra, Miguel P., Mathioni, Sandra Marisa, Santos, Karine Louise, Steindel, Mario, Vernal, Javier, Barcellos, Fernando G., Campo, Rubens J., Chueire, Ligia Maria O., Nicolás, Marisa Fabiana, Pereira-Ferrari, Lilian, da Conceição Silva, José L., Gioppo, Nereida M. R., Margarido, Vladimir P., Menck-Soares, Maria Amélia, Pinto, Fabiana Gisele S., Simão, Rita de Cássia G., Takahashi, Elizabete K., Yates, Marshall G., Souza, Emanuel M.
    Publicado 2011
    “…The genome contains a multitude of protein secretion systems, including type I, type II, type III, type V, and type VI secretion systems, and type IV pili, suggesting a high potential to interact with host plants. …”
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    Genome of Herbaspirillum seropedicae Strain SmR1, a Specialized Diazotrophic Endophyte of Tropical Grasses
  4. 15924
    “…(v) T-cell activation was reduced in mice exposed to SPE-like radiation with or without simulated hypogravity (either partial weight suspension or hindlimb suspension) (e.g. [4]). (vi) Radiation and simulated hypogravity had synergistic effects on immune system biological endpoints (e.g. [5]). …”
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    Acute effects of solar particle event radiation
  5. 15925
    “…Group V; an over-the-counter multivitamin. Group VI; none of the above. Phase II: 120 male BALB/c mice weighing 20-25g were randomly divided into 12 groups of 10 each. …”
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    A Comparative Study on the Life-Saving Radioprotective Effects of Vitamins A, E, C and Over-the-Counter Multivitamins
  6. 15926
    “…RESULTS: Our results reveal that: (i) FhCaMs are widely expressed in parenchymal cells throughout the forebody region of juvenile fluke; (ii) significant transcriptional knockdown of FhCaM1-3 was inducible by exposure to either long (~200 nt) double stranded (ds) RNAs or 27 nt short interfering (si) RNAs, although siRNAs were less effective than long dsRNAs; (iii) transient long dsRNA exposure-induced RNA interference (RNAi) of FhCaMs triggered transcript knockdown that persisted for ≥ 21 days, and led to detectable suppression of FhCaM proteins; (iv) FhCaM RNAi significantly reduced the growth of juvenile flukes maintained in vitro; (v) FhCaM RNAi juveniles also displayed hyperactivity encompassing significantly increased migration; (vi) both the reduced growth and increased motility phenotypes were recapitulated in juvenile fluke using the CaM inhibitor trifluoperazine hydrochloride, supporting phenotype specificity. …”
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    Calmodulin disruption impacts growth and motility in juvenile liver fluke
  7. 15927
    “…Il s'agit d'une étude prospective concernent 75 patients présentant une cellulite orbitaire, menée au service d'Ophtalmologie et d'ORL au CHU Mohammed VI de Marrakech, de Septembre 2010 au Avril 2014. …”
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    Les cellulites orbitaires: étude prospective à propos de 75 cas
  8. 15928
    “…These seven SPL genes belong to genes phylogeny clades VI, IV, VIII, V and VII, which have been reported to be targeted by miR156 in Arabidopsis thaliana. …”
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    Comparative transcriptome investigation of global gene expression changes caused by miR156 overexpression in Medicago sativa
  9. 15929
    “…Compared to controls, patients showed: 1) lower task-related activity in ipsilesional MI, SMA and contralesional cerebellum (lobules V-VI) and 2) higher activity in contralesional MI, superior temporal gyrus and OP1-OP4. …”
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    Parietal operculum and motor cortex activities predict motor recovery in moderate to severe stroke
  10. 15930
    “…To explain this TLC phenomenon that may have in our opinion a number of practical applications, especially for selective high throughput separation involving microchromatographic and/or microfluidic devices as well fractionation and extraction protocols (using, e.g., bar extraction systems), several experiments were conducted focusing on (i) acenaphthenol chromatography under different instrumental conditions, (ii) cyclodextrin retention measured as analyte or mobile phase additive, (iii) plate development time under different mobile phases and temperature settings, (iv) various column chromatographic conditions including C-30 and two C-18 stationary phases, (v) UV-Vis spectrophotometry, and (vi) microscopy inspection of precipitated CD-acenaphthenol crystals. …”
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    Unexpected differences between planar and column liquid chromatographic retention of 1-acenaphthenol enantiomers controlled by supramolecular interactions involving β-cyclodextrin at subambient temperatures
  11. 15931
    “…Accordingly, they upregulate lymphocyte-activation gene 3 (LAG-3), T cell immunoglobulin and mucin-3 (TIM-3), and/or programmed cell death-1 (PD-1), and acquire an anergic phenotype that interferes with their cognate function against Klebsiella pneumoniae and Escherichia coli; vi) MAIT cell hyperactivation and anergy co-utilize a signaling pathway that is governed by p38 and MEK1/2. …”
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    Online Artículo Texto
    MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression
  12. 15932
    “…Distinction of cellular biological characteristics between hAECs and hAMSCs was evaluated, such as collagen secretory level (collagen I, II, III, IV, and VI), telomerase activity, pluripotent markers tested by western blot, expression level of immune molecules (HLA-ABC and HLA-DR) analyzed by FACS, and cytokines (growth factors, chemotactic factors, apoptosis factors, and inflammatory factors) measured by a protein antibody array methodology. …”
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    Different therapeutic effects of cells derived from human amniotic membrane on premature ovarian aging depend on distinct cellular biological characteristics
  13. 15933
    “…Group IV was treated with 30% CCl(4) (1 mL/kg b.w.) i.p and silymarin intragastric. Group V and VI rats were treated with 30% CCl(4) and SCEE (150 and 300 mg/kg b.w., respectively) intragastric. …”
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    Phytochemical investigation and nephroprotective potential of Sida cordata in rat
  14. 15934
    “…Presence of T2DM and type VI plaques (with surface defect, hemorrhage or thrombus) had a profound impact on NGAL levels (both p < 0.01) in multiple linear regression analysis. …”
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    Neutrophil gelatinase associated lipocalin (NGAL) is elevated in type 2 diabetics with carotid artery stenosis and reduced under metformin treatment
  15. 15935
    “…Materials and METHODS: 55 patients with a mean age of 42 years (range 17–65 years) with tibial plateau fracture, were managed in our institution between October 2010 and September 2013., Twenty fractures were classified as Schatzker VI and 35 as Schatzker V. There were 8 open fractures (2 Gustilo Anderson 3A and 6 Gustilo Anderson 2). …”
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    Complex Tibial Plateau Fractures Treated by Hybrid External Fixation System: A correlation of followup computed tomography derived quality of reduction with clinical results
  16. 15936
    “…The complexes participate in an electrochemically reversible Mo(vi)/Mo(v) redox couple and react with cyanide undergoing decupration and desulfurization reactions of the type observed for CODH.…”
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    Models for aerobic carbon monoxide dehydrogenase: synthesis, characterization and reactivity of paramagnetic Mo(V)O(μ-S)Cu(I) complexes
  17. 15937
    “…The framework addresses 5 study stages (concept, planning and feasibility, conduct, analysis and interpretation, and reporting and knowledge translation) and includes the following dimensions: (i) protection of patient safety and rights, (ii) relevance/patient centeredness and involvement, (iii) minimization of bias (internal validity), (iv) precision, (v) transparency/access to data, and (vi) generalizability (external validity) of study results. …”
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    Academic response to improving value and reducing waste: A comprehensive framework for INcreasing QUality In patient-oriented academic clinical REsearch (INQUIRE)
  18. 15938
    “…Comparisons were made using a replicated Latin square design between: (i) short permethrin-treated overalls; (ii) long permethrin-treated overalls; (iii) short untreated overalls with para-menthane-3,8-diol (PMD) applied topically; (iv) short permethrin-treated overalls plus PMD applied topically; (v) short untreated overalls with metofluthrin coils in a metal casing worn on a belt; and (vi) long untreated overalls. Short untreated overalls served as the control. …”
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    Field evaluation of personal protection methods against outdoor-biting mosquitoes in Lao PDR
  19. 15939
    “…In the present work, we have evaluated the effects of these compounds on the (i) interaction with the lasB active site using in silico approaches, (ii) lasB proteolytic activity by using a specific fluorogenic peptide substrate, (iii) lasB gene expression by real time-polymerase chain reaction, (iv) lasB protein secretion by immunoblotting, (v) ability to block the damages induced by lasB on a monolayer of lung epithelial cells, and (vi) survivability of Galleria mellonella larvae after being challenged with purified lasB and lasB-rich bacterial secretions. …”
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    Disarming Pseudomonas aeruginosa Virulence by the Inhibitory Action of 1,10-Phenanthroline-5,6-Dione-Based Compounds: Elastase B (LasB) as a Chemotherapeutic Target
  20. 15940
    “…We enrolled 56 virally infected (VI) patients (pts): 13 HIV+ on suppressive cART (HIV-RNA < 40cp/ml), 13 HCV+ naive to DAA (direct-acting antiviral) anti-HCV agents; 30 HCV+/HIV+ on suppressive cART and naive to anti-HCV. 13 age-matched healthy controls (HC) were enrolled. …”
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    Association Between Impaired Vα7.2+CD161++CD8+ (MAIT) and Vα7.2+CD161-CD8+ T-Cell Populations and Gut Dysbiosis in Chronically HIV- and/or HCV-Infected Patients
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