Mostrando 1 - 20 Resultados de 140 Para Buscar '(A) Senile Animal', tiempo de consulta: 0.70s Limitar resultados
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    Rodent models of senile normal-pressure hydrocephalus
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    “…The mutation was not found in 13 unaffected unrelated animals but was found in an unrelated animal also diagnosed with senile congenital cataract. …”
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    A novel missense mutation in the HSF4 gene of giant pandas with senile congenital cataracts
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    Ceftriaxone improves senile neurocognition damages induced by D-galactose in mice
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    “…Adult SPF female Wistar rats were selected to establish a bilateral ovariectomized animal model (OVX), which simulated senile vaginitis dominated by estrogen deficiency in ovarian dysfunction. …”
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    Genistein Up-Regulates the Expression of EGF and E-Cadherin in the Treatment of Senile Vaginitis
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    “…The TG-EE group presented improved spatial memory when compared to the TG-Ctrl animals. In addition, the TG-EE group showed a 69.2% reduction in the total density of senile plaques in the hippocampus when compared to the TG-Ctrl group. …”
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    Enriched Environment Significantly Reduced Senile Plaques in a Transgenic Mice Model of Alzheimer’s Disease, Improving Memory
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    “…Mouse senile amyloidosis is a disorder in which apolipoprotein A-II (apoA-II) deposits as amyloid fibrils (AApoAII) and can be transmitted from one animal to another both by the feces and milk excreted by mice with amyloidosis. …”
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    Mouse Senile Amyloid Fibrils Deposited in Skeletal Muscle Exhibit Amyloidosis-Enhancing Activity
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    “…AIMS: We correlated the levels of GLP‐1 with spatial memory in senile animals to determine its role in memory improvement after prebiotic and probiotic supplementation. …”
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    Memory improvement in senile rats after prebiotic and probiotic supplementation is not induced by GLP‐1
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    por Wang, Ning, Ma, Sicong, Fu, Lingjie
    Publicado 2022
    “…Gut microbiota (GM) could regulate the bone metabolic process and be closely related to senile osteoporosis. Several genus-level GM were found to increase in osteoporotic animals and patients. …”
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    Gut Microbiota Feature of Senile Osteoporosis by Shallow Shotgun Sequencing Using Aged Rats Model
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    “…We hypothesized that the progressive decline of PACAP throughout life and the well‐known general cytoprotective effects of PACAP lead to age‐related pathophysiological changes in PACAP deficiency, supported by the increased vulnerability to various stressors of animals partially or totally lacking PACAP. Using young and aging CD1 PACAP knockout (KO) and wild type (WT) mice, we demonstrated pre‐senile amyloidosis in young PACAP KO animals and showed that senile amyloidosis appeared accelerated, more generalized, more severe, and affected more individuals. …”
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    Accelerated pre‐senile systemic amyloidosis in PACAP knockout mice – a protective role of PACAP in age‐related degenerative processes
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    “…OBJECTIVE: To evaluate the effect of different concentrations of estrogen on the ovarian superficial epithelium in senile female rats. Design: Fifty female rats at 15 months of age and with irregular estrous cycles were selected and randomly divided into five experimental groups containing equal numbers of animals in each: GPROP, control group receiving vehicle only; GE0.05mg, group receiving conjugated equine estrogens (CEE) at a dose of 50 μg/kg; GE0.5mg, group receiving CEE at 500 μg/kg; GE1mg, group receiving CEE at 1 mg/kg; and GE2mg, receiving CEE at 2 mg/kg. …”
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    Proliferation of the Superficial Epithelium of Ovaries in Senile Female Rats Following Oral Administration of Conjugated Equine Estrogens
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    por Trumbore, Conrad N.
    Publicado 2018
    “…Human and animal model studies report that senile plaques contain a halo of AβO molecules surrounding these plaques. …”
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    Shear-Induced Amyloid Formation in the Brain: IV. Effects on Synapses Surrounding Senile Plaque and in Plaque-Free Regions
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    “…BACKGROUND: Previous studies showed that isoflurane-induced cognitive deficits could be alleviated by dexmedetomidine in young animal subjects. In the current study, we examine whether dexmedetomidine could also alleviate isoflurane-induced cognitive deficits in senile animals. …”
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    Dexmedetomidine Acts via the JAK2/STAT3 Pathway to Attenuate Isoflurane-Induced Neurocognitive Deficits in Senile Mice
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    “…Altogether our data suggest that serotonergic denervation may interfere with some pathological aspects observed in AD, including tau phosphorylation or cognitive impairment, without affecting Aβ pathology, supporting a differential role of specific neurotransmitter systems in AD.…”
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    Specific Serotonergic Denervation Affects tau Pathology and Cognition without Altering Senile Plaques Deposition in APP/PS1 Mice
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    por North, Wheeler J.
    Publicado 1957
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    SENSITIVITY TO LIGHT IN THE SEA ANEMONE METRIDIUM SENILE (L.) : II. STUDIES OF REACTION TIME VARIABILITY AND THE EFFECTS OF CHANGES IN LIGHT INTENSITY AND TEMPERATURE
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    “…Although many animal species develop senile plaques (SP) composed of amyloid-β (Aβ) proteins that are identical to those found in humans, none of them exhibit neurofibrillary tangles (NFT) and subsequent neurodegeneration, which are integral parts of the pathology of AD. …”
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    The domestic cat as a natural animal model of Alzheimer’s disease
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    MACF1 overexpression in BMSCs alleviates senile osteoporosis in mice through TCF4/miR-335–5p signaling pathway
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    por Ito, Koichi
    Publicado 2013
    “…A model animal showing spontaneous onset is a useful tool for investigating the mechanism of disease. …”
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    Frontiers of Model Animals for Neuroscience:Two Prosperous Aging Model Animals forPromoting Neuroscience Research
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    por Loeffler, David A
    Publicado 2004
    “…An optimal animal model for studying the significance of complement activation on Alzheimer's – related neuropathology should have complete complement activation associated with senile plaques, neurofibrillary tangles (if present), and dystrophic neurites. …”
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    Using animal models to determine the significance of complement activation in Alzheimer's disease
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    por MacNider, William deB.
    Publicado 1917
    “…It would appear that in the response of dogs of different ages to uranium the animals represent a reaction system to this substance which shows an increasing susceptibility as the animal advances from youth to senility. …”
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    A CONSIDERATION OF THE RELATIVE TOXICITY OF URANIUM NITRATE FOR ANIMALS OF DIFFERENT AGES. I
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    “…Clinically, a diagnosis remains a postmortem one, hampering both accurate and early diagnosis as well as research into potential new treatments. …”
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    Ocular Manifestations of Alzheimer's Disease in Animal Models
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