X-ray structure and activities of an essential Mononegavirales L-protein domain

por Paesen, Guido C., Collet, Axelle, Sallamand, Corinne, Debart, Françoise, Vasseur, Jean-Jacques, Canard, Bruno, Decroly, Etienne, Grimes, Jonathan M.
Publicado 2015

A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome

por Shannon, Ashleigh, Sama, Bhawna, Gauffre, Pierre, Guez, Théo, Debart, Françoise, Vasseur, Jean-Jacques, Decroly, Etienne, Canard, Bruno, Ferron, François
Publicado 2022

Crystallization and diffraction analysis of the SARS coronavirus nsp10–nsp16 complex

por Debarnot, Claire, Imbert, Isabelle, Ferron, François, Gluais, Laure, Varlet, Isabelle, Papageorgiou, Nicolas, Bouvet, Mickaël, Lescar, Julien, Decroly, Etienne, Canard, Bruno
Publicado 2011

The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure

por Martin, Baptiste, Coutard, Bruno, Guez, Théo, Paesen, Guido C, Canard, Bruno, Debart, Françoise, Vasseur, Jean-Jacques, Grimes, Jonathan M, Decroly, Etienne
Publicado 2018

First insights into the structural features of Ebola virus methyltransferase activities

por Valle, Coralie, Martin, Baptiste, Ferron, François, Roig-Zamboni, Véronique, Desmyter, Aline, Debart, Françoise, Vasseur, Jean-Jacques, Canard, Bruno, Coutard, Bruno, Decroly, Etienne
Publicado 2021

Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect

por El Kazzi, Priscila, Rabah, Nadia, Chamontin, Célia, Poulain, Lina, Ferron, François, Debart, Françoise, Canard, Bruno, Missé, Dorothée, Coutard, Bruno, Nisole, Sébastien, Decroly, Etienne
Publicado 2022

Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases

por Hausdorff, Marcel, Delpal, Adrien, Barelier, Sarah, Nicollet, Laura, Canard, Bruno, Touret, Franck, Colmant, Agathe, Coutard, Bruno, Vasseur, Jean-Jacques, Decroly, Etienne, Debart, Françoise
Publicado 2023

Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites

por Shannon, Ashleigh, Le, Nhung Thi-Tuyet, Selisko, Barbara, Eydoux, Cecilia, Alvarez, Karine, Guillemot, Jean-Claude, Decroly, Etienne, Peersen, Olve, Ferron, Francois, Canard, Bruno
Publicado 2020

Amino Acid Polymorphisms on the Brazilian Strain of Yellow Fever Virus Methyltransferase Are Related to the Host’s Immune Evasion Mediated by Type I Interferon

por Furtado, Nathália Dias, de Mello, Iasmim Silva, de Godoy, Andre Schutzer, Noske, Gabriela Dias, Oliva, Glaucius, Canard, Bruno, Decroly, Etienne, Bonaldo, Myrna C.
Publicado 2023

Molecular Mapping of the RNA Cap 2′-O-Methyltransferase Activation Interface between Severe Acute Respiratory Syndrome Coronavirus nsp10 and nsp16

por Lugari, Adrien, Betzi, Stephane, Decroly, Etienne, Bonnaud, Emmanuel, Hermant, Aurélie, Guillemot, Jean-Claude, Debarnot, Claire, Borg, Jean-Paul, Bouvet, Mickaël, Canard, Bruno, Morelli, Xavier, Lécine, Patrick
Publicado 2010

Involvement of an Arginine Triplet in M1 Matrix Protein Interaction with Membranes and in M1 Recruitment into Virus-Like Particles of the Influenza A(H1N1)pdm09 Virus

por Kerviel, Adeline, Dash, Shantoshini, Moncorgé, Olivier, Panthu, Baptiste, Prchal, Jan, Décimo, Didier, Ohlmann, Théophile, Lina, Bruno, Favard, Cyril, Decroly, Etienne, Ottmann, Michèle, Roingeard, Philippe, Muriaux, Delphine
Publicado 2016

Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 Complex

por Decroly, Etienne, Debarnot, Claire, Ferron, François, Bouvet, Mickael, Coutard, Bruno, Imbert, Isabelle, Gluais, Laure, Papageorgiou, Nicolas, Sharff, Andrew, Bricogne, Gérard, Ortiz-Lombardia, Miguel, Lescar, Julien, Canard, Bruno
Publicado 2011

Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

por Ferron, François, Subissi, Lorenzo, Silveira De Morais, Ana Theresa, Le, Nhung Thi Tuyet, Sevajol, Marion, Gluais, Laure, Decroly, Etienne, Vonrhein, Clemens, Bricogne, Gérard, Canard, Bruno, Imbert, Isabelle
Publicado 2018

Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

por Shannon, Ashleigh, Selisko, Barbara, Le, Nhung-Thi-Tuyet, Huchting, Johanna, Touret, Franck, Piorkowski, Géraldine, Fattorini, Véronique, Ferron, François, Decroly, Etienne, Meier, Chris, Coutard, Bruno, Peersen, Olve, Canard, Bruno
Publicado 2020

Structure–function analysis of the nsp14 N7–guanine methyltransferase reveals an essential role in Betacoronavirus replication

por Ogando, Natacha S., El Kazzi, Priscila, Zevenhoven-Dobbe, Jessika C., Bontes, Brenda W., Decombe, Alice, Posthuma, Clara C., Thiel, Volker, Canard, Bruno, Ferron, François, Decroly, Etienne, Snijder, Eric J.
Publicado 2021

Le facteur temps ne sonne jamais deux fois

por Klein, Etienne
Publicado 2009

The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2’-O-methylation

por Sutto-Ortiz, Priscila, Tcherniuk, Sergey, Ysebaert, Nina, Abeywickrema, Pravien, Noël, Mathieu, Decombe, Alice, Debart, Françoise, Vasseur, Jean-Jacques, Canard, Bruno, Roymans, Dirk, Rigaux, Peter, Eléouët, Jean-François, Decroly, Etienne
Publicado 2021

Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay

por Aouadi, Wahiba, Eydoux, Cécilia, Coutard, Bruno, Martin, Baptiste, Debart, Françoise, Vasseur, Jean Jacques, Contreras, Jean Marie, Morice, Christophe, Quérat, Gilles, Jung, Marie-Louise, Canard, Bruno, Guillemot, Jean-Claude, Decroly, Etienne
Publicado 2017

Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro

por Thames, Joy E., Waters, Charles D., Valle, Coralie, Bassetto, Marcella, Aouadi, Wahiba, Martin, Baptiste, Selisko, Barbara, Falat, Arissa, Coutard, Bruno, Brancale, Andrea, Canard, Bruno, Decroly, Etienne, Seley-Radtke, Katherine L.
Publicado 2020

The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation

por Caruso, Marino, Meurant, Sébastien, Detraux, Damien, Mathieu, Amandine, Gilson, Manon, Dieu, Marc, Fattaccioli, Antoine, Demazy, Catherine, Najimi, Mustapha, Sokal, Etienne, Arnould, Thierry, Verfaillie, Catherine, Lafontaine, Denis L.J., Renard, Patricia
Publicado 2022