Design, Synthesis and Discovery of N,N’‐Carbazoyl‐aryl‐urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication

por Spizzichino, Sharon, Mattedi, Giulio, Lauder, Kate, Valle, Coralie, Aouadi, Wahiba, Canard, Bruno, Decroly, Etienne, Kaptein, Suzanne J. F., Neyts, Johan, Graham, Carl, Sule, Zakary, Barlow, David J., Silvestri, Romano, Castagnolo, Daniele
Publicado 2020

A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro

por De Castro, Sonia, Stevaert, Annelies, Maldonado, Miguel, Delpal, Adrien, Vandeput, Julie, Van Loy, Benjamin, Eydoux, Cecilia, Guillemot, Jean-Claude, Decroly, Etienne, Gago, Federico, Canard, Bruno, Camarasa, Maria-Jose, Velázquez, Sonsoles, Naesens, Lieve
Publicado 2022

Coronavirus Nsp10, a Critical Co-factor for Activation of Multiple Replicative Enzymes

por Bouvet, Mickaël, Lugari, Adrien, Posthuma, Clara C., Zevenhoven, Jessika C., Bernard, Stéphanie, Betzi, Stéphane, Imbert, Isabelle, Canard, Bruno, Guillemot, Jean-Claude, Lécine, Patrick, Pfefferle, Susanne, Drosten, Christian, Snijder, Eric J., Decroly, Etienne, Morelli, Xavier
Publicado 2014

C3P3-G1: first generation of a eukaryotic artificial cytoplasmic expression system

por Jaïs, Philippe H, Decroly, Etienne, Jacquet, Eric, Le Boulch, Marine, Jaïs, Aurélien, Jean-Jean, Olivier, Eaton, Heather, Ponien, Prishila, Verdier, Fréderique, Canard, Bruno, Goncalves, Sergio, Chiron, Stéphane, Le Gall, Maude, Mayeux, Patrick, Shmulevitz, Maya
Publicado 2019

Structure of the Respiratory Syncytial Virus Polymerase Complex

por Gilman, Morgan S.A., Liu, Cheng, Fung, Amy, Behera, Ishani, Jordan, Paul, Rigaux, Peter, Ysebaert, Nina, Tcherniuk, Sergey, Sourimant, Julien, Eléouët, Jean-François, Sutto-Ortiz, Priscila, Decroly, Etienne, Roymans, Dirk, Jin, Zhinan, McLellan, Jason S.
Publicado 2019

Viral evolution sustains a dengue outbreak of enhanced severity

por Inizan, Catherine, Minier, Marine, Prot, Matthieu, O’Connor, Olivia, Forfait, Carole, Laumond, Sylvie, Marois, Ingrid, Biron, Antoine, Gourinat, Ann-Claire, Goujart, Marie-Amélie, Descloux, Elodie, Sakuntabhai, Anavaj, Tarantola, Arnaud, Simon-Lorière, Etienne, Dupont-Rouzeyrol, Myrielle
Publicado 2021

System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2

por Vicenti, Ilaria, Martina, Maria Grazia, Boccuto, Adele, De Angelis, Marta, Giavarini, Giorgia, Dragoni, Filippo, Marchi, Serena, Trombetta, Claudia Maria, Crespan, Emmanuele, Maga, Giovanni, Eydoux, Cecilia, Decroly, Etienne, Montomoli, Emanuele, Nencioni, Lucia, Zazzi, Maurizio, Radi, Marco
Publicado 2021

An appeal for an objective, open, and transparent scientific debate about the origin of SARS-CoV-2

por van Helden, Jacques, Butler, Colin D, Achaz, Guillaume, Canard, Bruno, Casane, Didier, Claverie, Jean-Michel, Colombo, Fabien, Courtier, Virginie, Ebright, Richard H, Graner, François, Leitenberg, Milton, Morand, Serge, Petrovsky, Nikolai, Segreto, Rossana, Decroly, Etienne, Halloy, José
Publicado 2021

ERS International Congress 2021: highlights from the Pulmonary Vascular Diseases Assembly

por Lichtblau, Mona, Piccari, Lucilla, Ramjug, Sheila, Bokan, Aleksandar, Lechartier, Benoit, Jutant, Etienne-Marie, Barata, Margarida, Garcia, Agustin Roberto, Howard, Luke S., Adir, Yochai, Delcroix, Marion, Jara-Palomares, Luis, Bertoletti, Laurent, Sitbon, Olivier, Ulrich, Silvia, Vonk Noordegraaf, Anton
Publicado 2022

Identification of potent inhibitors of arenavirus and SARS-CoV-2 exoribonucleases by fluorescence polarization assay

por Hernández, Sergio, Feracci, Mikael, De Jesus, Carolina Trajano, El Kazzi, Priscila, Kaci, Rafik, Garlatti, Laura, Mondielli, Clemence, Bailly, Fabrice, Cotelle, Philippe, Touret, Franck, de Lamballerie, Xavier, Coutard, Bruno, Decroly, Etienne, Canard, Bruno, Ferron, François, Alvarez, Karine
Publicado 2022

Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity

por Essalmani, Rachid, Jain, Jaspreet, Susan-Resiga, Delia, Andréo, Ursula, Evagelidis, Alexandra, Derbali, Rabeb Mouna, Huynh, David N., Dallaire, Frédéric, Laporte, Mélanie, Delpal, Adrien, Sutto-Ortiz, Priscila, Coutard, Bruno, Mapa, Claudine, Wilcoxen, Keith, Decroly, Etienne, NQ Pham, Tram, Cohen, Éric A., Seidah, Nabil G.
Publicado 2022

Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex

por Hurdiss, Daniel L., El Kazzi, Priscila, Bauer, Lisa, Papageorgiou, Nicolas, Ferron, François P., Donselaar, Tim, van Vliet, Arno L.W., Shamorkina, Tatiana M., Snijder, Joost, Canard, Bruno, Decroly, Etienne, Brancale, Andrea, Zeev-Ben-Mordehai, Tzviya, Förster, Friedrich, van Kuppeveld, Frank J.M., Coutard, Bruno
Publicado 2022

A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

por Shannon, Ashleigh, Fattorini, Véronique, Sama, Bhawna, Selisko, Barbara, Feracci, Mikael, Falcou, Camille, Gauffre, Pierre, El Kazzi, Priscila, Delpal, Adrien, Decroly, Etienne, Alvarez, Karine, Eydoux, Cécilia, Guillemot, Jean-Claude, Moussa, Adel, Good, Steven S., La Colla, Paolo, Lin, Kai, Sommadossi, Jean-Pierre, Zhu, Yingxiao, Yan, Xiaodong, Shi, Hui, Ferron, François, Canard, Bruno
Publicado 2022

Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor

por Yu, Xiaodi, Abeywickrema, Pravien, Bonneux, Brecht, Behera, Ishani, Anson, Brandon, Jacoby, Edgar, Fung, Amy, Adhikary, Suraj, Bhaumik, Anusarka, Carbajo, Rodrigo J., De Bruyn, Suzanne, Miller, Robyn, Patrick, Aaron, Pham, Quyen, Piassek, Madison, Verheyen, Nick, Shareef, Afzaal, Sutto-Ortiz, Priscila, Ysebaert, Nina, Van Vlijmen, Herman, Jonckers, Tim H. M., Herschke, Florence, McLellan, Jason S., Decroly, Etienne, Fearns, Rachel, Grosse, Sandrine, Roymans, Dirk, Sharma, Sujata, Rigaux, Peter, Jin, Zhinan
Publicado 2023

Structure and functionality in flavivirus NS-proteins: Perspectives for drug design

por Bollati, Michela, Alvarez, Karin, Assenberg, René, Baronti, Cécile, Canard, Bruno, Cook, Shelley, Coutard, Bruno, Decroly, Etienne, de Lamballerie, Xavier, Gould, Ernest A., Grard, Gilda, Grimes, Jonathan M., Hilgenfeld, Rolf, Jansson, Anna M., Malet, Hélène, Mancini, Erika J., Mastrangelo, Eloise, Mattevi, Andrea, Milani, Mario, Moureau, Grégory, Neyts, Johan, Owens, Raymond J., Ren, Jingshan, Selisko, Barbara, Speroni, Silvia, Steuber, Holger, Stuart, David I., Unge, Torsten, Bolognesi, Martino
Publicado 2010

Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication

por Bardiot, Dorothée, Vangeel, Laura, Koukni, Mohamed, Arzel, Philippe, Zwaagstra, Marleen, Lyoo, Heyrhyoung, Wanningen, Patrick, Ahmad, Shamshad, Zhang, Linlin, Sun, Xinyuanyuan, Delpal, Adrien, Eydoux, Cecilia, Guillemot, Jean-Claude, Lescrinier, Eveline, Klaassen, Hugo, Leyssen, Pieter, Jochmans, Dirk, Castermans, Karolien, Hilgenfeld, Rolf, Robinson, Colin, Decroly, Etienne, Canard, Bruno, Snijder, Eric J., van Hemert, Martijn J., van Kuppeveld, Frank, Chaltin, Patrick, Neyts, Johan, De Jonghe, Steven, Marchand, Arnaud
Publicado 2022