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41“…AtSKL1 mutants yield albino and novel variegated phenotypes, which indicate SKL1 is required for chloroplast biogenesis. …”
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42por Nagai, Keisuke, Kurokawa, Yusuke, Mori, Yoshinao, Minami, Anzu, Reuscher, Stefan, Wu, Jianzhong, Matsumoto, Takashi, Ashikari, Motoyuki“…A yeast one-hybrid assay showed that the C-end of SKL1 has transcription activity, as do the C-ends of SK1 and SK2. …”
Publicado 2022
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43“…The klotho gene encodes a type I single-pass transmembrane protein that contains a large extracellular domain, a membrane spanning segment, and a short intracellular domain. …”
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44por Tan, Sven-Jean, Chu, Melissa M, Toussaint, Nigel D, Cai, Michael MX, Hewitson, Tim D, Holt, Stephen G“…A standard Bruce protocol treadmill exercise was undertaken by 10 fasting healthy volunteers. sKl, sPi, and blood glucose levels were measured in samples collected 1-week prior, immediately pre (T (pre)), 0 (T (post)), 30 (T (30)), 240 (T (240)) min, and 1-week after exercise. …”
Publicado 2018
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45por Neidert, Marian Christoph, Zeitlberger, Anna Maria, Leske, Henning, Tschopp, Oliver, Sze, Lisa, Zwimpfer, Cornelia, Wiesli, Peter, Bellut, David, Bernays, René-Ludwig, Rushing, Elisabeth Jane, Schmid, Christoph“…Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) have been assessed as biomarker for disease activity, however the value of sKl as a predictive biomarker of surgical success has not been evaluated yet. …”
Publicado 2022
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46por Kakareko, Katarzyna, Rydzewska-Rosolowska, Alicja, Brzosko, Szymon, Gozdzikiewicz-Lapinska, Joanna, Koc-Zorawska, Ewa, Samocik, Pawel, Kozlowski, Robert, Mysliwiec, Michal, Naumnik, Beata, Hryszko, Tomasz“…Nephrectomy significantly decreased sKL level [709.8 (599.9–831.2) vs. 583.0 (411.7–752.6) pg/ml, p < 0.001] and did not change c-FGF-23 concentration [70.5 (49.8–103.3) vs. 77.1 (60.5–109.1) RU/ml, p = 0.9]. …”
Publicado 2017
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47por Baccam, Gabriel C., Xie, Jian, Jin, Xin, Park, Hyejung, Wang, Bing, Husson, Hervé, Ibraghimov-Beskrovnaya, Oxana, Huang, Chou-Long“…We have shown that sKL protects the heart by regulating the formation and function of lipid rafts by targeting the sialic acid moiety of gangliosides, GM1/GM3. …”
Publicado 2022
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48por Sakan, Hirokazu, Nakatani, Kimihiko, Asai, Osamu, Imura, Akihiro, Tanaka, Tomohiro, Yoshimoto, Shuhei, Iwamoto, Noriyuki, Kurumatani, Norio, Iwano, Masayuki, Nabeshima, Yo-ichi, Konishi, Noboru, Saito, Yoshihiko“…Renal α-Klotho (α-KL) plays a fundamental role as a co-receptor for fibroblast growth factor 23 (FGF23), a phosphaturic hormone and regulator of 1,25(OH)(2) vitamin D(3) (1,25VitD(3)). …”
Publicado 2014
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49por Münz, Sina, Wolf, Lisa, Hoelzle, Ludwig E., Chernyakov, Dmitry, Edemir, Bayram, Föller, Michael“…Gene expression was determined by qRT-PCR, sKL by ELISA, apoptosis and necrosis by annexin V binding and a fluorescent DNA dye, and cell viability by MTT assay. …”
Publicado 2022
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50por Pongpiachan, Siwatt, Tipmanee, Danai, Choochuay, Chomsri, Deelaman, Woranuch, Iadtem, Natthapong, Wang, Qiyuan, Xing, Li, Li, Guohui, Han, Yongming, Hashmi, Muhammad Zaffar, Cao, Junji, Leckngam, Apichart, Poshyachinda, Saran“…The ΣPAH concentrations observed in SKL and NHL sediments (n = 135) were in the range of 19.4–1,218 ng g(−1) and 94.5–1,112 ng g(−1), respectively. …”
Publicado 2022
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51“…In conclusion, compound H attenuates aging‐associated arterial stiffness and hypertension by activation of DNA demethylase which increases renal SKL expression and consequently circulating SKL levels leading to activation of the Sirt1‐AMPK‐eNOS pathway in aortas of aged mice.…”
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52por da Silva, Maria Fernanda Laranjeira, Zampieri, Ricardo Andrade, Muxel, Sandra M., Beverley, Stephen M., Floeter-Winter, Lucile M.“…In contrast, restoration of a cytosol-targeted ARG lacking the glycosomal SKL targeting sequence (argΔSKL) restored growth but failed to restore infectivity. …”
Publicado 2012
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53por Ruff, Eugen, Widmann, Sebastian, Lunkenheimer, Peter, Tsurkan, Vladimir, Bordács, Sandor, Kézsmárki, Istvan, Loidl, Alois“…These include the SkL phase, where we predict a strong spatial modulation of FE polarization close to the skyrmion cores. …”
Publicado 2015
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54Publicado 1995“…Pay mutants of the yeast Yarrowia lipolytica fail to assemble functional peroxisomes. One mutant strain, pay32-1, has abnormally small peroxisomes that are often found in clusters surrounded by membraneous material. …”
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55por Arimura, Gen-ichiro, Garms, Stefan, Maffei, Massimo, Bossi, Simone, Schulze, Birgit, Leitner, Margit, Mithöfer, Axel, Boland, Wilhelm“…The addition of jasmonic acid (JA) induced expression of the TPS genes, but terpenoid emission was higher from plants treated with JA and the ethylene precursor 1-amino-cyclopropyl-1-carboxylic acid. Compared to infested wild-type M. truncatula plants, lower amounts of various sesquiterpenes and a C(11)–homoterpene were released from an ethylene-insensitive mutant skl. …”
Publicado 2007
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56por Crespo-Herrera, Leonardo, Singh, Ravi P., Reynolds, Matthew, Huerta-Espino, Julio“…Other minor QTL on chromosomes 2B, 3A, and 7B were also identified. The QTL on 2B and 3A originated from Weebill1. …”
Publicado 2019
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57Progression of arterial stiffness is associated with changes in bone mineral markers in advanced CKDpor Krishnasamy, Rathika, Tan, Sven-Jean, Hawley, Carmel M., Johnson, David W., Stanton, Tony, Lee, Kevin, Mudge, David W., Campbell, Scott, Elder, Grahame J., Toussaint, Nigel D., Isbel, Nicole M.“…There were no differences in age, gender and body mass index between groups. A significant increase in FGF23 [240.6 (141.9–1129.8) to 396.8 (160.3–997.7) pg/mL, p = 0.001] was observed in the CKD group but serum phosphate, corrected calcium, parathyroid hormone and sKl did not change significantly over 12 m. …”
Publicado 2017
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58“…Gall and egg formation were significantly reduced in the ethylene insensitive, hypernodulating mutant skl (sickle), and to a lesser extent, in the low nodulation, abscisic acid insensitive mutant latd/nip (lateral root-organ defective/numerous infections and polyphenolics). …”
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59por Lee, Gyunghee, Sehgal, Ritika, Wang, Zixing, Nair, Sudershana, Kikuno, Keiko, Chen, Chun-Hong, Hay, Bruce, Park, Jae H.“…To reveal death genes responsible for the PCD of vCrz neurons, we examined extant and recently available mutations as well as RNA interference that disrupt functions of single or multiple death genes. We found grim as a chief proapoptotic gene and skl and rpr as minor ones. …”
Publicado 2013
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60“…Specifically, HNPCs were treated with SKL2001 (an agonist in the Wnt/β-catenin pathway) or XAV-939 (an inhibitor of the Wnt/β-catenin pathway), and pressurized under the hydrostatic pressure of 1, 3 and 30 atm. …”
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