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341por Takahashi, Tomoko, Akagawa, Mao, Kimura, Ryusuke, Sada, Mitsuru, Shirai, Tatsuya, Okayama, Kaori, Hayashi, Yuriko, Kondo, Mayumi, Takeda, Makoto, Ryo, Akihide, Kimura, Hirokazu“…Almost all conformational epitopes of the F protein, except one in each monomer, did not correspond to the neutralising antibody (NT-Ab) binding sites. These results suggest that the HRV1 F gene has constantly evolved over many years, infecting humans, while the gene may be relatively conserved. …”
Publicado 2023
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342“…The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus is continuously evolving, and this poses a major threat to antibody therapies and currently authorized Coronavirus Disease 2019 (COVID-19) vaccines. …”
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343por Waters, Patrick, Reindl, Markus, Saiz, Albert, Schanda, Kathrin, Tuller, Friederike, Kral, Vlastimil, Nytrova, Petra, Sobek, Ondrej, Nielsen, Helle Hvilsted, Barington, Torben, Lillevang, Søren T, Illes, Zsolt, Rentzsch, Kristin, Berthele, Achim, Berki, Tímea, Granieri, Letizia, Bertolotto, Antonio, Giometto, Bruno, Zuliani, Luigi, Hamann, Dörte, van Pelt, E Daniëlle, Hintzen, Rogier, Höftberger, Romana, Costa, Carme, Comabella, Manuel, Montalban, Xavier, Tintoré, Mar, Siva, Aksel, Altintas, Ayse, Deniz, Günnur, Woodhall, Mark, Palace, Jacqueline, Paul, Friedemann, Hartung, Hans-Peter, Aktas, Orhan, Jarius, Sven, Wildemann, Brigitte, Vedeler, Christian, Ruiz, Anne, Leite, M Isabel, Trillenberg, Peter, Probst, Monika, Saschenbrecker, Sandra, Vincent, Angela, Marignier, Romain“…We report the results of a multicentre study of aquaporin (AQP) 4 antibody (AQP4-Ab) assays in neuromyelitis optica spectrum disorders (NMOSD). …”
Publicado 2016
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344“…A strain of the Asian corn borer (ACB), Ostrinia furnacalis (Guenée), has evolved >800-fold resistance to Cry1Ie (ACB-IeR) after 49 generations of selection. …”
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345“…Unlike plants, cyanobacteria evolved a carbon-concentrating organelle called the carboxysome—a proteinaceous compartment that encapsulates and concentrates Rubisco along with its CO(2) substrate. …”
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346por Pal, Archana, Dobhal, Shefali, Dey, Kishore Kumar, Sharma, Anish Kumar, Savani, Vivek, Negi, Vishal Singh“…We also find some evidence of localized positive selections ORF1ab, spike glycoprotein, and nucleocapsid. The CDSs for ORF3a, ORF8, nucleocapsid phosphoprotein, and spike glycoprotein were found to evolve at rapid rate. …”
Publicado 2021
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347por Carvalho, Sofia B., Gomes, Ricardo A., Pfenninger, Anja, Fischer, Martina, Strotbek, Michaela, Isidro, Inês A., Tugçu, Nihal, Gomes-Alves, Patrícia“…Quality control of biopharmaceuticals such as monoclonal antibodies (mAbs) has been evolving and becoming more challenging as the requirements of the regulatory agencies increase due to the demanding complexity of products under evaluation. …”
Publicado 2022
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348“…Towards this goal, we have analyzed two cooperating antibodies, DH475 and DH272, which exerted pressure on the HIV population in an infected donor, called CH848, to evolve in such a way that it became sensitive to the V3-glycan supersite DH270 bnAb lineage. …”
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349“…However, in fungi, the development of resistance against these drugs quickly evolved. Candida is a dimorphic fungus that can switch between yeast to hyphae form, requires an active biosynthesis of membrane constituents. …”
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350por Varchetta, Stefania, Brunetta, Enrico, Roberto, Alessandra, Mikulak, Joanna, Hudspeth, Kelly L., Mondelli, Mario U., Mavilio, Domenico“…This inhibitory function can be also targeted by several pathogens that have evolved to express sialic acids on their surface to escape host immune responses. …”
Publicado 2012
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351por Trouillon, Julian, Sentausa, Erwin, Ragno, Michel, Robert-Genthon, Mylène, Lory, Stephen, Attrée, Ina, Elsen, Sylvie“…To gain insights into this functional dichotomy, we defined the pan-regulon of ErfA in several Pseudomonas species and found ergAB as the sole conserved target of ErfA. The analysis of 446 exlBA promoter sequences from all exlBA(+) genomes revealed a wide variety of regulatory sequences, as ErfA- and Vfr-binding sites were found to have evolved specifically in P. aeruginosa and nearly each species carries different regulatory sequences for this operon. …”
Publicado 2020
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352por Taylor, Katherine L., Hamby, Kelly A., DeYonke, Alexandra M., Gould, Fred, Fritz, Megan L.“…Genomic scans of wild H. zea were paired with quantitative trait locus (QTL) analyses and showed the genomic architecture of field-evolved Cry1Ab resistance was polygenic, likely arising from standing genetic variation. …”
Publicado 2021
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353por Pisanic, Nora, Antar, Annukka A. R., Kruczynski, Kate, Rivera, Magdielis Gregory, Dhakal, Santosh, Spicer, Kristoffer, Randad, Pranay R., Pekosz, Andrew, Klein, Sabra L., Betenbaugh, Michael J., Detrick, Barbara, Clarke, William, Thomas, David L., Manabe, Yukari C., Heaney, Christopher D.“…A salivary SARS-CoV-2 IgG MIA produced consistently high Se (>98.8%) and Sp (>99.1%) across two bead coupling scales and correlations with nAb responses that were similar to blood-based SARS-CoV-2 IgG ELISA data. …”
Publicado 2022
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354por Pisanic, Nora, Antar, Annukka A.R., Kruczynski, Kate L., Gregory Rivera, Magdielis, Dhakal, Santosh, Spicer, Kristoffer, Randad, Pranay R., Pekosz, Andrew, Klein, Sabra L., Betenbaugh, Michael J., Detrick, Barbara, Clarke, William, Thomas, David L., Manabe, Yukari C., Heaney, Christopher D.“…CONCLUSIONS: A salivary SARS-CoV-2 IgG MIA produced consistently high Se (> 98.8%) and Sp (> 99.1%) across two bead coupling scales and correlations with nAb responses that were similar to blood-based SARS-CoV-2 IgG ELISA data. …”
Publicado 2023
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355por Addetia, Amin, Park, Young-Jun, Starr, Tyler, Greaney, Allison J., Sprouse, Kaitlin R., Bowen, John E., Tiles, Sasha W., Van Voorhis, Wesley C., Bloom, Jesse D., Corti, Davide, Walls, Alexandra C., Veesler, David“…The SARS-CoV-2 receptor-binding domain (RBD) E406W mutation abrogates neutralization mediated by the REGEN-COV therapeutic monoclonal antibody (mAb) COVID-19 cocktail and the AZD1061 (COV2-2130) mAb. …”
Publicado 2023
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356por Bose Nandy, Sushmita, Subramani, Ramadevi, Rajamanickam, Venkatesh, Lopez-Valdez, Rebecca, Arumugam, Arunkumar, Boopalan, Thiyagarajan, Lakshmanaswamy, Rajkumar“…Among the important genes were Lifr, Acvr1c, and Pparγ which were found to be targeted by microRNAs in our dataset like miR-143, miR-30, miR-140, miR-27b, miR-125a, miR-128ab, miR-342, miR-26ab, miR-181, miR-150, miR-23ab and miR-425. …”
Publicado 2014
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357“…The electron-bifurcating flavoprotein complexes known to date fall into four groups that have evolved independently, namely those containing EtfAB (CarED, LctCB, FixBA) with bound FAD, a NuoF homolog (HydB, HytB, or HylB) harboring FMN, NfnB with bound FAD, or HdrA harboring FAD. …”
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358por Simonich, Cassandra A., Doepker, Laura, Ralph, Duncan, Williams, James A., Dhar, Amrit, Yaffe, Zak, Gentles, Lauren, Small, Christopher T., Oliver, Brian, Vigdorovich, Vladimir, Mangala Prasad, Vidya, Nduati, Ruth, Sather, D. Noah, Lee, Kelly K., Matsen IV, Frederick A., Overbaugh, Julie“…Here we reconstruct the developmental lineage of BF520.1, an infant-derived HIV-specific broadly neutralizing antibody (bnAb), using computational methods developed specifically for this purpose. …”
Publicado 2019
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359por Huang, Deli, Tran, Jenny Tuyet, Olson, Alex, Vollbrecht, Thomas, Tenuta, Mary, Guryleva, Mariia V., Fuller, Roberta P., Schiffner, Torben, Abadejos, Justin R., Couvrette, Lauren, Blane, Tanya R., Saye, Karen, Li, Wenjuan, Landais, Elise, Gonzalez-Martin, Alicia, Schief, William, Murrell, Ben, Burton, Dennis R., Nemazee, David, Voss, James E.“…Somatic hypermutation after immunization indicates that engineered cells have the capacity to respond to an evolving pathogen. These results encourage further exploration of engineered B cell vaccines as a strategy for durable elicitation of HIV bnAbs to protect against infection and as a contributor to a functional HIV cure.…”
Publicado 2020
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360“…The Ebro Valley (Spain) is the only hotspot area in Europe where resistance evolution of target pests to Cry1Ab protein is most likely, owing to the high and regular adoption of Bt maize (>60%). …”
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