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521“…Voltage-sensor domains couple membrane potential to conformational changes in voltage-gated ion channels and phosphatases. Highly co-evolved acidic and aromatic side-chains assist the transfer of cationic side-chains across the transmembrane electric field during voltage-sensing. …”
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522“…These ab initio-level force-fields could eventually evolve toward universal organic/polymeric/biomolecular systems.…”
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523“…The resulting layers evolve along the c axis perpendicular to the ab plane. …”
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524por Doores, Katie J.“…The high density of glycans creates a shield that impedes antibody recognition but, critically, some of the most potent and broadly active bnAbs have evolved to recognize epitopes formed by these glycans. …”
Publicado 2015
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525por Ratnapriya, Sneha, Pothula, Karunakar Reddy, Dam, Kim-Marie A., Parthasarathy, Durgadevi, Benet, Héctor Cervera, Parsons, Ruth, Huang, Xiao, Sammour, Salam, Janowska, Katarzyna, Harris, Miranda, Ahmed, Shamim, Sacco, Samuel, Sodroski, Joseph, Bridges, Michael D., Hubbell, Wayne L., Acharya, Priyamvada, Herschhorn, Alon“…To follow the fate of incompletely closed Env in patients, we reconstructed de novo the post-transmission evolutionary pathway of a second T/F Env (CH040), which is sensitive to the V3-targeting antibody 19b and highly resistant to most bnAbs. …”
Publicado 2023
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526por Navarro-Vázquez, Armando“…The base-catalyzed isomerization of N-propargylamides or carbamates may furnish N-allenyl compounds (allenamides/allencarbamates) or further evolve to N-alkynyl compounds (ynamides or yncarbamates). …”
Publicado 2015
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527por Barik, Sailen“…It appears that the AAR genes have evolved by orchestrating a balance between codon usage and mRNA secondary structure. …”
Publicado 2017
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528por Brazevic, Sabina, Nizinski, Stanisław, Sliwa, Michel, Abe, Jiro, Rode, Michał F., Burdzinski, Gotard“…In terms of optimized photo-switchable materials, synthetic efforts are nowadays evolving toward developing 3H-naphthopyran derivatives that would not be able to photoproduce the long-living transoid-trans, TT, photoproduct. …”
Publicado 2020
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529por Morè, Sonia, Petrucci, Maria Teresa, Corvatta, Laura, Fazio, Francesca, Offidani, Massimo, Olivieri, Attilio“…However, therapeutic options for this disease are constantly evolving and immunotherapy is becoming the mainstay of the therapeutic armamentarium of Multiple Myeloma (MM), starting with monoclonal antibodies (MoAbs) as elotuzumab, daratumumab and isatuximab. …”
Publicado 2020
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530“…Mismatches were detected in seven, two, two, and six assays targeting the ORF1ab, spike, envelope, and nucleocapsid genes, respectively. …”
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531por Angoletta, M-E, Belochitskii, P, Borburgh, J, Breuker, H, Buzio, M, Capatina, O, Chiggiato, P, Ducimetière, L, Eriksson, T, Fowler, T, Hori, M, Lacroix, J-M, LeGodec, G, Lelong, P, Maury, S, Möhl, D, Newborough, A, Nisbet, D, Oelert, W, Pasinelli, S, Puccio, B, Sermeus, L, Soby, L, Tommasini, D, Tranquille, G, Vorozhtsov, A“…Since the initial estimate, published in 2007 (CERN-AB-2007-079), the ELENA design has evolved considerably. …”
Publicado 2010
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532“…As the field of MIGS continues to evolve, it is crucial to prioritize high-quality, long-term studies to better understand the safety and effectiveness of these innovative interventions in glaucoma management.…”
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533“…With earlier use of CPI and brentuximab vedotin, the optimal sequencing of therapy is evolving. In this review, we will summarize clinical investigation of anti-PD-1 mAb in earlier line settings to provide insights on utilizing these agents as chemotherapy- and radiation-sparing approaches, increasing depth of response, and as part of combination regimens.…”
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534“…In this paper, we present a novel ab-initio approach to solve the many-body problem for bosonic systems by evolving a system of one-particle wavefunctions representing pilot waves that guide the Bohmian trajectories of the quantum particles. …”
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535“…We have only a vague idea of precisely how protein sequences evolve in the context of protein structure and function. …”
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536por Werner, Felix, Schwardmann, Lynn S., Siebert, Daniel, Rückert-Reed, Christian, Kalinowski, Jörn, Wirth, Marie-Theres, Hofer, Katharina, Takors, Ralf, Wendisch, Volker F., Blombach, Bastian“…FAL biosynthesis was further optimized by overexpression of the pntAB genes encoding the membrane-bound transhydrogenase of E. coli. …”
Publicado 2023
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537“…More recently, a targeted approach to MM treatment has emerged, using monoclonal antibodies (mAbs) to target antigens expressed on the surface of MM cells. …”
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538por Lázár, Viktória, Pal Singh, Gajinder, Spohn, Réka, Nagy, István, Horváth, Balázs, Hrtyan, Mónika, Busa-Fekete, Róbert, Bogos, Balázs, Méhi, Orsolya, Csörgő, Bálint, Pósfai, György, Fekete, Gergely, Szappanos, Balázs, Kégl, Balázs, Papp, Balázs, Pál, Csaba“…Whole-genome sequencing of laboratory-evolved strains revealed multiple mechanisms underlying aminoglycoside resistance, including a reduction in the proton-motive force (PMF) across the inner membrane. …”
Publicado 2013
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539por Lee, Jeong Hyun, Andrabi, Raiees, Su, Ching-Yao, Yasmeen, Anila, Julien, Jean-Philippe, Kong, Leopold, Wu, Nicholas C., McBride, Ryan, Sok, Devin, Pauthner, Matthias, Cottrell, Christopher A., Nieusma, Travis, Blattner, Claudia, Paulson, James C., Klasse, Per Johan, Wilson, Ian A., Burton, Dennis R., Ward, Andrew B.“…Using cryo-electron microscopy, we solved the atomic structure of an apex bnAb, PGT145, in complex with Env. …”
Publicado 2017
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540por Wu, Nicholas C., Grande, Geramie, Turner, Hannah L., Ward, Andrew B., Xie, Jia, Lerner, Richard A., Wilson, Ian A.“…The relatively recent discovery and characterization of human broadly neutralizing antibodies (bnAbs) against influenza virus provide valuable insights into antiviral and vaccine development. …”
Publicado 2017
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