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581por Lee, Ivan T, Cosgrove, Catherine A, Moore, Patrick, Bula, Marcin, Kalra, Philip, Dargan, Paul, Clark, Rebecca, Boffito, Marta, Sheridan, Ray, Bethune, Claire, Burns, Fiona, Saralaya, Dinesh, Nally, Rhiannon, Duncan, Christopher J A, Chadwick, David, Palfreeman, Adrian, Ramos, Alberto San Francisco, Heath, Paul T, Girard, Bethany, Sellers, Kristen, de Windt, Elizabeth, Sutherland, Andrea, Tracy, LaRee, Zhou, Honghong, Miller, Jacqueline, Priddy, Frances, Chalkias, Spyros, Das, Rituparna“…These results support variant-updated vaccines to protect against evolving SARS-CoV-2. DISCLOSURES: Ivan T. Lee, MD, PhD, Moderna, Inc.: Salary|Moderna, Inc.: Stocks/Bonds Catherine A. …”
Publicado 2023
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582por Phillips, Angela M, Maurer, Daniel P, Brooks, Caelan, Dupic, Thomas, Schmidt, Aaron G, Desai, Michael M“…Recent advances have enabled us to isolate and engineer these antibodies as therapeutics, but eliciting them through vaccination remains challenging, in part due to our limited understanding of how antibodies evolve breadth. Here, we analyze the landscape by which an anti-influenza receptor binding site (RBS) bnAb, CH65, evolved broad affinity to diverse H1 influenza strains. …”
Publicado 2023
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583por Schwickert, David, Ruberti, Marco, Kolorenč, Přemysl, Usenko, Sergey, Przystawik, Andreas, Baev, Karolin, Baev, Ivan, Braune, Markus, Bocklage, Lars, Czwalinna, Marie Kristin, Deinert, Sascha, Düsterer, Stefan, Hans, Andreas, Hartmann, Gregor, Haunhorst, Christian, Kuhlmann, Marion, Palutke, Steffen, Röhlsberger, Ralf, Rönsch-Schulenburg, Juliane, Schmidt, Philipp, Toleikis, Sven, Viefhaus, Jens, Martins, Michael, Knie, André, Kip, Detlef, Averbukh, Vitali, Marangos, Jon P., Laarmann, Tim“…In the kinematically complete x-ray absorption measurement, we monitor its dynamics for a period of 175 fs and observe an evolving modulation that may implicate the coupling of electronic to vibronic coherence at longer time scales. …”
Publicado 2022
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584“…The ability to use the Dsr pathway for sulfur oxidation evolved at least twice, with Chlorobi and Proteobacteria being extant descendants of these two independent adaptations.…”
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585por Weil-Olivier, Catherine, Salisbury, David, Navarro-Alonso, José Antonio, Tzialla, Chryssoula, Zhang, Yan, Esposito, Susanna, Midulla, Fabio, Tenenbaum, Tobias“…The lack of precedent for mAbs for broad population protection creates challenges in the assessment of upcoming prophylactic long-acting mAbs for RSV, with associated consequences in legislative and registration categorization, as well as in recommendation, funding, and implementation pathways. …”
Publicado 2023
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586por Qiu, Hongjie, Sun, Shihui, Xiao, He, Feng, Jiannan, Guo, Yan, Tai, Wanbo, Wang, Yufei, Du, Lanying, Zhao, Guangyu, Zhou, Yusen“…Here, we generated a humanized monoclonal antibody (mAb), designated hMS-1, which targeted the MERS-CoV receptor-binding domain (RBD) with high affinity. hMS-1 significantly blocked MERS-CoV RBD binding to its viral receptor, human dipeptidyl peptidase 4 (hDPP4), potently neutralized infection by a prototype MERS-CoV, and effectively cross-neutralized evolved MERS-CoV isolates through recognizing highly conserved RBD epitopes. …”
Publicado 2016
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587por Rockne, Russell C, Hawkins-Daarud, Andrea, Swanson, Kristin R, Sluka, James P, Glazier, James A, Macklin, Paul, Hormuth, David A, Jarrett, Angela M, Lima, Ernesto A B F, Oden, J Tinsley, Biros, George, Yankeelov, Thomas E, Curtius, Kit, Bakir, Ibrahim Al, Wodarz, Dominik, Komarova, Natalia, Aparicio, Luis, Bordyuh, Mykola, Rabadan, Raul, Finley, Stacey D, Enderling, Heiko, Caudell, Jimmy, Moros, Eduardo G, Anderson, Alexander R A, Gatenby, Robert A, Kaznatcheev, Artem, Jeavons, Peter, Krishnan, Nikhil, Pelesko, Julia, Wadhwa, Raoul R, Yoon, Nara, Nichol, Daniel, Marusyk, Andriy, Hinczewski, Michael, Scott, Jacob GEnlace del recurso
Publicado 2019
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588“…The results of the epidemiological model show that while the COVID-19 evolved in multiple waves, government restrictions and vaccinations are keys to control the spread of the virus. …”
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589por Kabylda, Adil, Vassilev-Galindo, Valentin, Chmiela, Stefan, Poltavsky, Igor, Tkatchenko, Alexandre“…Machine learning force fields (MLFFs) are gradually evolving towards enabling molecular dynamics simulations of molecules and materials with ab initio accuracy but at a small fraction of the computational cost. …”
Publicado 2023
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590“…As an application, interference patterns of the magnetic type-I Aharonov-Bohm (AB) effect are obtained by evolving atoms along a circle over several tens of lattice cells. …”
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591por Xiao, Yutao, Zhang, Tao, Liu, Chenxi, Heckel, David G., Li, Xianchun, Tabashnik, Bruce E., Wu, Kongming“…Toxins from the bacterium Bacillus thuringiensis (Bt) are used widely for insect control in sprays and transgenic plants, but their efficacy is reduced when pests evolve resistance. Previous work showed that mutations in a gene encoding the transporter protein ABCC2 are linked with resistance to Bt toxins Cry1Ab, Cry1Ac or both in four species of Lepidoptera. …”
Publicado 2014
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592“…A down-regulatory mechanism, thus, has been evolved (non-photochemical quenching, NPQ). The mechanistic details of its major component (qE) are missing at the atomic scale. …”
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593por Wang, Pengfei, Casner, Ryan G., Nair, Manoj S., Yu, Jian, Guo, Yicheng, Wang, Maple, Chan, Jasper F.-W., Cerutti, Gabriele, Iketani, Sho, Liu, Lihong, Sheng, Zizhang, Chen, Zhiwei, Yuen, Kwok-Yung, Kwong, Peter D., Huang, Yaoxing, Shapiro, Lawrence, Ho, David D.“…By screening monoclonal antibodies (mAbs) isolated from COVID-19-convalescent patients, we found one mAb, 2–36, with cross-neutralizing activity against SARS-CoV. …”
Publicado 2021
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594por Wang, Pengfei, Casner, Ryan G., Nair, Manoj S., Yu, Jian, Guo, Yicheng, Wang, Maple, Chan, Jasper F.-W., Cerutti, Gabriele, Iketani, Sho, Liu, Lihong, Sheng, Zizhang, Chen, Zhiwei, Yuen, Kwok-Yung, Kwong, Peter D., Huang, Yaoxing, Shapiro, Lawrence, Ho, David D.“…By screening monoclonal antibodies (mAbs) isolated from COVID-19-convalescent patients, we found one mAb, 2-36, with cross-neutralizing activity against SARS-CoV. …”
Publicado 2021
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595por Aureli, Alessia, Bocchini, Sarah, Mariani, Michela, Crinò, Antonino, Cappa, Marco, Fintini, Danilo“…During endocrinological follow up she developed impaired glucose tolerance with positive markers of β-cell autoimmunity (anti-glutamic acid decarboxylase antibodies, GAD Ab), which evolved over time into type 1 diabetes mellitus and insulin therapy with a basal-bolus scheme and an appropriate diet were needed.…”
Publicado 2023
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596por Meganck, Rita M., Zhu, Deanna, Dong, Stephanie, Snoderly-Foster, Lisa J., Dalben, Yago R., Thiono, Devina, White, Laura J., DeSilva, Aravinda M., Baric, Ralph S., Tse, Longping V.“…The FL mutations were combined with our previously evolved prM cleavage site to create a mature version of D2-FL (D2-FLM), which evades both prM- and FL-Abs but retains sensitivity to other type-specific and quaternary cross-reactive (CR) Abs. …”
Publicado 2023
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597por Leyn, Semen A., Kent, James E., Zlamal, Jaime E., Elane, Marinela L., Vercruysse, Maarten, Osterman, Andrei L.“…To gain this knowledge, we combine experimental evolution in a continuous culturing device, the morbidostat, with whole genome sequencing of evolving cultures followed by characterization of drug-resistant isolates. …”
Publicado 2023
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598por Meganck, Rita M, Zhu, Deanna, Dong, Stephanie, Snoderly-Foster, Lisa J, Dalben, Yago R, Thiono, Devina, White, Laura J, DeSilva, Arivianda M, Baric, Ralph S, Tse, Longping V“…The FL mutations were combined with our previously evolved prM cleavage site to create a mature version of D2-FL (D2-FLM), which evades both prM- and FL-Abs but retains sensitivity to other type-specific and quaternary cross-reactive (CR) Abs. …”
Publicado 2023
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599por Ridlon, Jason M., Ikegawa, Shigeo, Alves, João M. P., Zhou, Biao, Kobayashi, Akiko, Iida, Takashi, Mitamura, Kuniko, Tanabe, Genzoh, Serrano, Myrna, De Guzman, Ainee, Cooper, Patsy, Buck, Gregory A., Hylemon, Phillip B.“…Phylogenetic analysis suggests this operon is rare in nature and the desC gene evolved from a gene encoding threonine dehydrogenase. …”
Publicado 2013
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600por Zhang, Hui, Hall, Nathan, Goertzen, Leslie R., Chen, Charles Y., Peatman, Eric, Patel, Jinesh, McElroy, J. Scott“…Domesticated E. coracana evolved from wild E. africana (E. coracana ssp. africana) with the maternal genome donor largely supported to be E. indica; however, the paternal genome donor remains elusive. …”
Publicado 2019
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