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81por Osl, Theresa, Schmidt, Alexander, Schwaiger, Markus, Schottelius, Margret, Wester, Hans-Jürgen“…To this aim, a series of DOTA-conjugated CPCR4- and iodoCPCR4-based ligands with new linker structures, replacing the AMBA-linker in PentixaFor and PentixaTher, were synthesized and evaluated. …”
Publicado 2020
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82por Chung, Eunsook, Cho, Chang-Woo, So, Hyun-Ah, Kang, Jee-Sook, Chung, Young Soo, Lee, Jai-Heon“…Yeast two-hybrid and bimolecular fluorescence complementation demonstrated that VrUBC1 interacts with AtVBP1 (A. thaliana VrUBC1 Binding Partner 1), a C3HC4-type RING E3 ligase. Overall, these results demonstrate that VrUBC1 plays a positive role in osmotic stress tolerance through transcriptional regulation of ABA-related genes and possibly through interaction with a novel RING E3 ligase.…”
Publicado 2013
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83por Yang, Jing-Fang, Yin, Chun-Yan, Wang, Di, Jia, Chen-Yang, Hao, Ge-Fei, Yang, Guang-Fu“…As an important ABA-mimicking ligand, Pyrabactin shows the activation function to parts of members of PYLs, such as PYR1 and PYL1. …”
Publicado 2020
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84“…ABF2 is also an in vitro ubiquitination substrate of the E3 ligase KEG and recombinant ABF2 is stable in keg lysates. …”
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85por Kim, Min-Ha, Cho, Jin-Seong, Park, Eung-Jun, Lee, Hyoshin, Choi, Young-Im, Bae, Eun-Kyung, Han, Kyung-Hwan, Ko, Jae-Heung“…XERICO, a RING (Really Interesting New Gene) zinc-finger E3 ubiquitin ligase, has been shown to be a positive regulator of drought tolerance in plants through the control of abscisic acid (ABA) homeostasis. …”
Publicado 2020
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86por Sun, Jin, Chen, Jiaqi, Si, Xinyu, Liu, Weikang, Yuan, Mingzhu, Guo, Shirong, Wang, Yu“…Furthermore, overexpression of cucumber miR396b-5p in Arabidopsis improved cold tolerance. 5’ RNA ligase-mediated rapid amplification of cDNA ends (5’ RLM-RACE) and transient transformation experiments demonstrated that TPR was the target gene of miR396b-5p, while TPR overexpression plants were hypersensitive to cold stress. …”
Publicado 2022
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87por Albertos, Pablo, Romero-Puertas, María C., Tatematsu, Kiyoshi, Mateos, Isabel, Sánchez-Vicente, Inmaculada, Nambara, Eiji, Lorenzo, Oscar“…S-nitrosylation of ABI5 at cysteine-153 facilitates its degradation through CULLIN4-based and KEEP ON GOING E3 ligases, and promotes seed germination. Conversely, mutation of ABI5 at cysteine-153 deregulates protein stability and inhibition of seed germination by NO depletion. …”
Publicado 2015
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88por Bechard, Matthew E., Farahani, Payam, Greene, Dina, Pham, Anna, Orry, Andrew, Rasche, Madeline E.“…In the static model, D19 is located close to the active site, yet appears too far away to influence ligand binding directly. This may be indicative of the protein conformational change predicted previously in the Bi-Ter kinetic mechanism and/or formation of the active site at the interface of two subunits. …”
Publicado 2019
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89por Ngo, Thi Tuyen, Masi, Sofia, Mendez, Perla F., Kazes, Miri, Oron, Dan, Seró, Iván Mora“…We test PSCs fabricated with PbS QD additives with different capping ligands including methylammonium lead iodide (MAPI), cesium lead iodide (CsPI) and 4-aminobenzoic acid (ABA). …”
Publicado 2019
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90por Kim, Joo Yong, Lee, Seung Ju, Min, Wang Ki, Cha, Seoyeon, Song, Jong Tae, Seo, Hak Soo“…Constitutive photomorphogenic 1 (COP1) is an E3 ubiquitin ligase that is involved in plant growth and development and multiple abiotic stress responses by regulating the stability of various target proteins. …”
Publicado 2022
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91por Lee, Sang-Uk, Mun, Bong-Gyu, Bae, Eun-Kyung, Kim, Jae-Young, Kim, Hyun-Ho, Shahid, Muhammad, Choi, Young-Im, Hussain, Adil, Yun, Byung-Wook“…Furthermore, we identified several key differences in the amino acid sequence, predicted structure, and co-factor/ligand binding activity of NCED3 between drought-tolerant and susceptible P. davidiana cultivars. …”
Publicado 2021
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92por Chen, Jing, Nguyen, Huong T. X., Yang, Ming, Zeng, Fangxun, Xu, Hang, Liang, Fu-Sen, Wang, Wei“…We have also engineered a new version of ABA-CIP with an enhanced ligand-responding sensitivity. …”
Publicado 2023
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93por Zhang, Zhiwei, Liu, Yang, Zhao, Jing, Li, Wenqiang, Hu, Ruiwen, Li, Xia, Li, Aitao, Wang, Yaping, Ma, Lixin“…RESULTS: Based on the docking model using α-ketobutyric acid as the ligand, 6 amino acid residues, consisting of Y20, L57, W58, G229, A230 and M419, were chosen for saturation mutagenesis. …”
Publicado 2021
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94por Koops, Petra, Pelser, Stephan, Ignatz, Michael, Klose, Cornelia, Marrocco-Selden, Katia, Kretsch, Thomas“…Thus, the protein is presumed to act as a component of a ubiquitin ligase complex that specifically directs negatively acting factors in ABA signalling to degradation via the proteasome.…”
Publicado 2011
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95por Cao, Min-Jie, Zhang, Yu-Lu, Liu, Xue, Huang, Huan, Zhou, X. Edward, Wang, Wen-Long, Zeng, Ai, Zhao, Chun-Zhao, Si, Tong, Du, Jiamu, Wu, Wen-Wu, Wang, Fu-Xing, Xu, H. Eric, Zhu, Jian-Kang“…Here, we report that adding fluorine atoms in the benzyl ring of the abscisic acid (ABA) receptor agonist AM1 optimizes its binding to ABA receptors by increasing the number of hydrogen bonds between the compound and the surrounding amino acid residues in the receptor ligand-binding pocket. …”
Publicado 2017
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96por Harith-Fadzilah, Nazmi, Lam, Su Datt, Haris-Hussain, Mohammad, Ghani, Idris Abd, Zainal, Zamri, Jalinas, Johari, Hassan, Maizom“…Interspecies molecular docking analysis between RPW ligands and OP receptor proteins provided putative interactions that result in ABA signalling activation. …”
Publicado 2021
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97“…According to the molecular docking analysis of the protein-ligand complex, Hyp with a high affinity for AbaI showed a binding affinity of − 9.41 kcal/mol. …”
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98The COP9 Signalosome regulates seed germination by facilitating protein degradation of RGL2 and ABI5por Jin, Dan, Wu, Ming, Li, Bosheng, Bücker, Birte, Keil, Philipp, Zhang, Shaoman, Li, Jigang, Kang, Dingming, Liu, Jie, Dong, Jie, Deng, Xing Wang, Irish, Vivian, Wei, Ning“…The COP9 Signalosome (CSN) is a conserved multi-subunit protein complex that is best known as a regulator of the Cullin-RING family of ubiquitin E3 ligases (CRLs). Multiple viable mutants of the CSN showed poor germination, except for csn5b-1. …”
Publicado 2018
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99por Venkatesan, Meenakshi, Fruci, Michael, Verellen, Lou Ann, Skarina, Tatiana, Mesa, Nathalie, Flick, Robert, Pham, Chester, Mahadevan, Radhakrishnan, Stogios, Peter J., Savchenko, Alexei“…Here, we determine crystal structures of the most common Sul enzyme types (Sul1, Sul2 and Sul3) in multiple ligand-bound states, revealing a substantial reorganization of their pABA-interaction region relative to the corresponding region of DHPS. …”
Publicado 2023
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100“…Therefore; TF interaction partners such as E3 ubiquitin ligases and TF regions with ID represent future targets for engineering improved abiotic stress tolerance in crops.…”
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