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241por Giallini, Ilaria, Nicastri, Maria, Inguscio, Bianca M. S., Portanova, Ginevra, Magliulo, Giuseppe, Greco, Antonio, Mancini, Patrizia“…INTRODUCTION: The present study aimed to evaluate the effects of the Active Communication Education (ACE) program on the social/emotional impacts of hearing loss (HL) in a group of older adults with a cochlear implant (CI). …”
Publicado 2022
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242por Lopes-Pacheco, Miquéias, Silva, Pedro Leme, Cruz, Fernanda Ferreira, Battaglini, Denise, Robba, Chiara, Pelosi, Paolo, Morales, Marcelo Marcos, Caruso Neves, Celso, Rocco, Patricia Rieken Macedo“…Virion binding to ACE2 for host cell entry leads to internalization of both via endocytosis, as well as activation of ADAM17/TACE, resulting in downregulation of ACE2 and loss of its protective actions in the lungs and other organs. …”
Publicado 2021
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243“…Loss of this activity constitutes the potential basis for the renal damage that occurs in COVID-19 patients. …”
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244por Boguszewicz, Ł., Bieleń, A., Mrochem-Kwarciak, J., Skorupa, A., Ciszek, M., Heyda, A., Wygoda, A., Kotylak, A., Składowski, K., Sokół, M.“…RESULTS: PCA has detected a group of distinct outliers corresponding to ketone bodies (3HB, Ace, AceAce). These outliers were found to identify the individuals at high risk of weight loss, mainly by the 3HB changes, which was confirmed by the patients’ medical data. …”
Publicado 2019
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245por Stewart, C. Allison, Gay, Carl M., Ramkumar, Kavya, Cargill, Kasey R., Cardnell, Robert J., Nilsson, Monique B., Heeke, Simon, Park, Elizabeth M., Kundu, Samrat T., Diao, Lixia, Wang, Qi, Shen, Li, Xi, Yuanxin, Zhang, Bingnan, Della Corte, Carminia Maria, Fan, Youhong, Kundu, Kiran, Gao, Boning, Avila, Kimberley, Pickering, Curtis R., Johnson, Faye M., Zhang, Jianjun, Kadara, Humam, Minna, John D., Gibbons, Don L., Wang, Jing, Heymach, John V., Byers, Lauren Averett“…COVID-19 is an infectious disease caused by SARS-CoV-2, which enters host cells via the cell surface proteins ACE2 and TMPRSS2. Using a variety of normal and malignant models and tissues from the aerodigestive and respiratory tracts, we investigated the expression and regulation of ACE2 and TMPRSS2. …”
Publicado 2021
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246por Oliveira, Sandra Helena Penha, Brito, Victor Gustavo Balera, Frasnelli, Sabrina Cruz Tfaile, Ribeiro, Bianca da Silva, Ferreira, Milena Nunes, Queiroz, Dayane Priscilla, Beltan, Carluci Taís, Lara, Vanessa Soares, Santos, Carlos Ferreira“…PD inhibited ACE2 in N but not in D. MasR expression was unaffected in both N and D with PD. …”
Publicado 2019
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247por Fakhouri, Eddie W., Peterson, Stephen J., Kothari, Janish, Alex, Ragin, Shapiro, Joseph I., Abraham, Nader G.“…This is further complicated by genetic polymorphisms of CYP2D6, HO-1, ACE, and ACE-2. There is a potential role for HO-1 upregulation to treat/prevent cytokine storm. …”
Publicado 2020
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248por Gowda, Pruthvi, Patrick, Shruti, Joshi, Shanker Datt, Kumawat, Rajesh Kumar, Sen, Ellora“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19) is associated with uncontrolled inflammatory responses. Loss of pulmonary angiotensin-converting enzyme 2 (ACE2) function has been associated with SARS-CoV-2 infection. …”
Publicado 2021
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249“…Similarly, prophylactic intranasal treatment with nafamostat reduced weight loss, viral burden, and mortality in K18-hACE2 transgenic mice. …”
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250“…Neurological symptoms and the neurological effects induced by SARS-CoV-2, such as the loss of various sensory perceptions, indicate direct viral invasion into sensory neurons. …”
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251por Liu, Lin, Chopra, Pradeep, Li, Xiuru, Bouwman, Kim M., Tompkins, S. Mark, Wolfert, Margreet A., de Vries, Robert P., Boons, Geert-Jan“…Furthermore, an enzymatic removal of HS proteoglycan from physiological relevant tissue resulted in a loss of RBD binding. The data support a model in which HS functions as the point of initial attachment allowing the virus to travel through the glycocalyx by low-affinity high-avidity interactions to reach the cell membrane, where it can engage with ACE2 for cell entry. …”
Publicado 2021
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252por Chen, Jian, Fan, Jun, Chen, Zhilu, Zhang, Miaomiao, Peng, Haoran, Liu, Jian, Ding, Longfei, Liu, Mingbin, Zhao, Chen, Zhao, Ping, Zhang, Shuye, Zhang, Xiaoyan, Xu, Jianqing“…Finally, we demonstrated that loss of MYH9 reduces authentic SARS-CoV-2 infection in Calu-3, ACE2-A549, and ACE2-H1299 cells. …”
Publicado 2021
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253por Momotomi, Fuzuki, Raju, Aedla, Wang, Dongxing, Alsaadi, Doaa H. M., Watanabe, Takashi“…Cardiocrinum cordatum, known as ubayuri in Japan, has antihypertensive properties and has been shown to inhibit angiotensin-converting enzyme (ACE), which contributes to the production of angiotensin II, a hypotensive substance in the renin–angiotensin system. …”
Publicado 2022
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254por Hassan, Ahmed O., Case, James Brett, Winkler, Emma S., Thackray, Larissa B., Kafai, Natasha M., Bailey, Adam L., McCune, Broc T., Fox, Julie M., Chen, Rita E., Alsoussi, Wafaa B., Turner, Jackson S., Schmitz, Aaron J., Lei, Tingting, Shrihari, Swathi, Keeler, Shamus P., Fremont, Daved H., Greco, Suellen, McCray, Paul B., Perlman, Stanley, Holtzman, Michael J., Ellebedy, Ali H., Diamond, Michael S.“…Commercially available laboratory strains of mice are not readily infected by SARS-CoV-2 because of species-specific differences in their angiotensin-converting enzyme 2 (ACE2) receptors. Here, we transduced replication-defective adenoviruses encoding human ACE2 via intranasal administration into BALB/c mice and established receptor expression in lung tissues. hACE2-transduced mice were productively infected with SARS-CoV-2, and this resulted in high viral titers in the lung, lung pathology, and weight loss. …”
Publicado 2020
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255por Stewart, C. Allison, Gay, Carl M., Ramkumar, Kavya, Cargill, Kasey R., Cardnell, Robert J., Nilsson, Monique B., Heeke, Simon, Park, Elizabeth M., Kundu, Samrat T., Diao, Lixia, Wang, Qi, Shen, Li, Xi, Yuanxin, Zhang, Bingnan, Della Corte, Carminia Maria, Fan, Youhong, Kundu, Kiran, Gao, Boning, Avila, Kimberley, Pickering, Curtis R., Johnson, Faye M., Zhang, Jianjun, Kadara, Humam, Minna, John D., Gibbons, Don L., Wang, Jing, Heymach, John V., Byers, Lauren Averett“…INTRODUCTION: Coronavirus disease 2019 is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which enters host cells through the cell surface proteins ACE2 and TMPRSS2. METHODS: Using a variety of normal and malignant models and tissues from the aerodigestive and respiratory tracts, we investigated the expression and regulation of ACE2 and TMPRSS2. …”
Publicado 2021
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256por Daniloski, Zharko, Jordan, Tristan X., Wessels, Hans-Hermann, Hoagland, Daisy A., Kasela, Silva, Legut, Mateusz, Maniatis, Silas, Mimitou, Eleni P., Lu, Lu, Geller, Evan, Danziger, Oded, Rosenberg, Brad R., Phatnani, Hemali, Smibert, Peter, Lappalainen, Tuuli, tenOever, Benjamin R., Sanjana, Neville E.“…Using single-cell RNA-sequencing, we identify shared transcriptional changes in cholesterol biosynthesis upon loss of top-ranked genes. In addition, given the key role of the ACE2 receptor in the early stages of viral entry, we show that loss of RAB7A reduces viral entry by sequestering the ACE2 receptor inside cells. …”
Publicado 2021
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257por Bharucha, Nike, Chabrier-Roselló, Yeissa, Xu, Tao, Johnson, Cole, Sobczynski, Sarah, Song, Qingxuan, Dobry, Craig J., Eckwahl, Matthew J., Anderson, Christopher P., Benjamin, Andrew J., Kumar, Anuj, Krysan, Damian J.“…Further analysis indicates that the RAM and PKA pathways co-regulate a common set of genes during morphogenesis and that hyper-activation of the PKA pathway may compensate for loss of RAM pathway function. Our data also indicate that the PKA–regulated transcription factor Efg1 primarily localizes to yeast phase cells while the RAM–pathway regulated transcription factor Ace2 localizes to daughter nuclei of filamentous cells, suggesting that Efg1 and Ace2 regulate a common set of genes at separate stages of morphogenesis. …”
Publicado 2011
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258por Agrawal, Deepashri, Timm, Lydia, Viola, Filipa Campos, Debener, Stefan, Büchner, Andreas, Dengler, Reinhard, Wittfoth, Matthias“…In sensori-neural hearing loss, impaired speech perception can be improved by cochlear implants (CIs). …”
Publicado 2012
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259por Spratt, Austin N., Kannan, Saathvik R., Woods, Lucas T., Weisman, Gary A., Quinn, Thomas P., Lorson, Christian L., Sönnerborg, Anders, Byrareddy, Siddappa N., Singh, Kamal“…However, reported greater binding affinity of N501Y Spike with ACE2 does not seem to be entirely due to increased hydrophobic interactions, given that Spike mutation R417T in P.1 or K417N in B.1.351 results in the loss of a salt-bridge interaction between ACE2 and S-RBD. …”
Publicado 2021
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260“…Complex self-sufficiency problems, measured by the number of people who had self-sufficiency problems in 4+ domains and the number of people who had similar self-sufficiency problems as homeless people in Amsterdam, were found in 35.3 and 32.4% of the client sample. The most prevalent ACE were emotional neglect (47.1%), household mental illness (44.1%), and loss of a parent (38.2%), 35.3% had been exposed to 4+ ACE. …”
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