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281por Schnichels, Sven, Rohrbach, Jens Martin, Bayyoud, Tarek, Thaler, Sebastian, Ziemssen, Focke, Hurst, José“…In the eye both ACE2 and TMPRSS2 are expressed, although sometimes very weakly and with varying degrees in different tissues. …”
Publicado 2020
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282“…Additionally, by inducing an imbalance in the renin-angiotensin-aldosterone system (RAAS) and the loss of ACE2 would favour the progression of inflammatory and thrombotic processes in the lungs. …”
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283“…The Acute Care for Elders (ACE) is a model of care addressed to reduce the incidence of loss of self-care abilities of older adults occurring during hospitalization for acute illness. …”
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284por Golden, Joseph W., Cline, Curtis R., Zeng, Xiankun, Garrison, Aura R., Carey, Brian D., Mucker, Eric M., White, Lauren E., Shamblin, Joshua D., Brocato, Rebecca L., Liu, Jun, Babka, April M., Rauch, Hypaitia B., Smith, Jeffrey M., Hollidge, Bradley S., Fitzpatrick, Collin, Badger, Catherine V., Hooper, Jay W.“…In contrast to nontransgenic mice, intranasal exposure of K18-hACE2 animals to 2 different doses of SARS-CoV-2 resulted in acute disease, including weight loss, lung injury, brain infection, and lethality. …”
Publicado 2020
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285por Schnichels, Sven, Rohrbach, Jens Martin, Bayyoud, Tarek, Thaler, Sebastian, Ziemssen, Focke, Hurst, José“…In the eye both ACE2 and TMPRSS2 are expressed, although sometimes very weakly and with varying degrees in different tissues. …”
Publicado 2020
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286“…Clinical and experimental evidence shows that loss of function of ACE2 aggravates pulmonary hypertension and gain of function of ACE2 exerts protection on cardiopulmonary circulation. …”
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287por Neta, Francisca Idalina, Fernandes, Amélia Carolina Lopes, Vale, Adson José Martins, Pinheiro, Francisco Irochima, Cobucci, Ricardo Ney, Azevedo, Eduardo Pereira de, Guzen, Fausto Pierdoná“…SARS-CoV-2 infects host cells mainly through the interaction between the virus's Spike protein and the viral receptors namely Angiotensin-Converting Enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). …”
Publicado 2021
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288por Coden, Mackenzie E., Loffredo, Lucas F., Abdala-Valencia, Hiam, Berdnikovs, Sergejs“…Overall, changes in SARS-CoV-2-related gene expression were specific to the Th2 high molecular endotype of asthma and different by asthma severity and airway location. The downregulation of ACE2 (COVID-19, SARS) and ANPEP (HCoV-229E) viral receptors wascorrelated with loss of club and ciliated cells in Th2 high asthma. …”
Publicado 2021
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289por Henin, Dolaji, Pellegrini, Gaia, Carmagnola, Daniela, Lanza Attisano, Giuseppe Carlo, Lopez, Gianluca, Ferrero, Stefano, Amendola, Antonella, De Angelis, Danilo, Tanzi, Elisabetta, Dellavia, Claudia“…The oral manifestations of COVID-19 often involve the tongue, with loss of taste being one of the most common symptoms of the disease. …”
Publicado 2022
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290por Currey, Joshua M., Rabito, Felix, Maness, Nicholas J., Blair, Robert V., Rappaport, Jay, Qin, Xuebin, Kolls, Jay K., Srivastava, Akhilesh K.“…Prior reports have shown that VOC infection without expression of human angiotensin converting enzyme-2 receptor (hACE2) in mice is possible. We sought to understand if the increased transmissibility of VOCs can infect C57BL/6 mice without expression of hACE2 receptor required for entry of SARS-CoV-2 normally. …”
Publicado 2022
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291por Chadwick, Benjamin J, Pham, Tuyetnhu, Xie, Xiaofeng, Ristow, Laura C, Krysan, Damian J, Lin, Xiaorong“…However, no Ace2 homolog or any downstream component of the RAM pathway has been identified in basidiomycetes. …”
Publicado 2022
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292por Diamond, Michael, Halfmann, Peter, Maemura, Tadashi, Iwatsuki-Horimoto, Kiyoko, Iida, Shun, Kiso, Maki, Scheaffer, Suzanne, Darling, Tamarand, Joshi, Astha, Loeber, Samantha, Foster, Stephanie, Ying, Baoling, Whitener, Bradley, Floyd, Katharine, Ujie, Michiko, Nakajima, Noriko, Ito, Mutsumi, Wright, Ryan, Uraki, Ryuta, Li, Rong, Sakai, Yuko, Liu, Yanan, Larson, Deanna, Osorio, Jorge, Hernandez-Ortiz, Juan, Čiuoderis, Karl, Florek, Kelsey, Patel, Mit, Bateman, Allen, Odle, Abby, Wong, Lok-Yin, Wang, Zhongde, Edara, Venkata Viswanadh, Chong, Zhenlu, Thackray, Larissa, Ueki, Hiroshi, Yamayoshi, Seiya, Imai, Masaki, Perlman, Stanley, Webby, Richard, Seder, Robert, Suthar, Mehul, Garcia-Sastre, Adolfo, Schotsaert, Michael, Suzuki, Tadaki, Boon, Adrianus, Kawaoka, Yoshihiro, Douek, Daniel, Moliva, Juan, Sullivan, Nancy, Gagne, Matthew, Ransier, Amy, Case, James, Jeevan, Trushar, Franks, John, Fabrizio, Thomas, DeBeauchamp, Jennifer, Kercher, Lisa, Seiler, Patrick, Singh, Gagandeep, Warang, Prajakta, Gonzalez-Reiche, Ana S., Sordillo, Emilia, van Bakel, Harm, Simon, Viviana“…Although K18-hACE2 transgenic mice sustained infection in the lungs, these animals did not lose weight. …”
Publicado 2021
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293“…Severe acute respiratory syndrome coronavirus (SARS-CoV-2) infections result in the temporary loss of smell and taste (anosmia and dysgeusia) in about one third of confirmed cases. …”
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294por Törmänen, Suvi, Pörsti, Ilkka, Lakkisto, Päivi, Tikkanen, Ilkka, Niemelä, Onni, Paavonen, Timo, Mustonen, Jukka, Eräranta, Arttu“…Sitaxentan and cinacalcet reduced kidney renin mRNA by 40%, while their combination alleviated tubulointerstitial damage and urinary calcium loss, and increased kidney tissue ACE2 mRNA. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12882-017-0742-z) contains supplementary material, which is available to authorized users.…”
Publicado 2017
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295por Bagasra, Omar, Pandey, Pratima, Sanamandra, Jessica R., Houston, Jarrett M., McLean, Ewen, Albrecht, Helmut“…ACE2 expression slightly increased in CRL-127 post RA-treatment. …”
Publicado 2021
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296por Batta, Yashvardhan, King, Cody, Johnson, John, Haddad, Natasha, Boueri, Myriam, Haddad, Georges“…However, studies suggest several links to high angiotensin-converting enzyme 2 (ACE2) expression in myocardial and endothelial cells, systemic hyper-inflammation, an imbalance between myocardial oxygen supply and demand, and loss of ACE2-mediated cardio-protection. …”
Publicado 2022
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297por Houben, Philipp, Khajeh, Elias, Hinz, Ulf, Knebel, Phillip, Diener, Markus K., Mehrabi, Arianeb“…Intraoperative total blood loss is the primary endpoint of the trial. Secondary endpoints include blood loss during hepatectomy, the duration of both the hepatectomy and the entire surgical procedure, and blood transfusion requirements of the procedure. …”
Publicado 2018
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298por Vitale-Cross, Lynn, Szalayova, Ildiko, Scoggins, Aiden, Palkovits, Miklos, Mezey, Eva“…BACKGROUND: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections result in the temporary loss of smell and taste in about one third of confirmed cases. …”
Publicado 2022
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299por Chung, Esther O., Scherer, Elissa, LeMasters, Katherine, Bates, Lisa, Hagaman, Ashley, Staley, Brooke S., Zalla, Lauren C., Sikander, Siham, Maselko, Joanna“…To estimate the associations between maternal ACEs and child outcomes, we used multivariable generalized linear models with inverse probability weights to account for sampling and loss to follow-up. …”
Publicado 2023
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300“…BACKGROUND: The longitudinal outcomes of patients admitted to acute care for elders units (ACE) are mixed. We studied the associations between socio-demographic and functional measures with hospital length of stay (LOS), and which variables predicted adverse events (non-independent living, readmission, death) 3 and 6 months later. …”
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