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481“…Estimated blood loss (EBL), ranged from less than 5cc to 47cc for a bilateral nephrectomy. …”
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482“…Addition of amiloride (5 mg/day) to treatment resulted in resolution of edema, weight loss of 7 kg, reduction in blood pressure (150/100–125/81 mmHg), increased 24 h urinary sodium excretion (127–165 mmol/day), decreased eGFR (41–29 mL/min), and increased plasma potassium concentration (4.6–7.8 mmol/L). …”
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483por De Rosa, Gianluca, Andolfo, Immacolata, Marra, Roberta, Manna, Francesco, Rosato, Barbara Eleni, Iolascon, Achille, Russo, Roberta“…CDA II is an autosomal recessive disorder due to loss-of-function mutations in SEC23B. Currently, management of patients with CDA II is based on transfusions, splenectomy, or hematopoietic stem-cell transplantation. …”
Publicado 2020
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484por Wei, Jin, Alfajaro, Mia Madel, Hanna, Ruth E., DeWeirdt, Peter C., Strine, Madison S., Lu-Culligan, William J., Zhang, Shang-Min, Graziano, Vincent R., Schmitz, Cameron O., Chen, Jennifer S., Mankowski, Madeleine C., Filler, Renata B., Gasque, Victor, de Miguel, Fernando, Chen, Huacui, Oguntuyo, Kasopefoluwa, Abriola, Laura, Surovtseva, Yulia V., Orchard, Robert C., Lee, Benhur, Lindenbach, Brett, Politi, Katerina, van Dijk, David, Simon, Matthew D., Yan, Qin, Doench, John G., Wilen, Craig B.“…We also revealed that the alarmin HMGB1 is critical for SARS-CoV-2 replication. In contrast, loss of the histone H3.3 chaperone complex sensitized cells to virus-induced death. …”
Publicado 2020
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485“…Although COVID-19 is predominantly a respiratory illness, other systems including gastrointestinal (GI) system and liver may be involved because of the ubiquitous nature of ACE-2 receptors in various cell lines that SARS-CoV-2 utilizes to enter host cells. …”
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486por Divani, Afshin A., Andalib, Sasan, Biller, José, Di Napoli, Mario, Moghimi, Narges, Rubinos, Clio A., Nobleza, Christa O’Hana, Sylaja, P. N, Toledano, Michel, Lattanzi, Simona, McCullough, Louise D, Cruz-Flores, Salvador, Torbey, Michel, Azarpazhooh, M. Reza“…The disease arises from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that binds to angiotensin-converting enzyme 2 (ACE2) receptors on host cells for its internalization. …”
Publicado 2020
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487por Esparza, Thomas J., Chen, Yaozong, Martin, Negin P., Bielefeldt-Ohmann, Helle, Bowen, Richard A., Tolbert, William D., Pazgier, Marzena, Brody, David L.“…In an in vivo pilot study, we demonstrate effective reductions in weight loss, viral burden, and lung pathology in a Syrian hamster model of COVID-19 following nebulized delivery of NIH-CoVnb-112. …”
Publicado 2021
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488por Pierros, Vasileios, Kontopodis, Evangelos, Stravopodis, Dimitrios J., Tsangaris, George Th.“…Extensive analysis has indicated that the critical P681R mutation produces new C/H-CrUPs around the R685 cleavage site, while the L452R mutation causes loss of antigenicity of the NF9 peptide and strong(er) binding of the virus to its ACE2 receptor protein. …”
Publicado 2022
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489por Six, Isabelle, Guillaume, Nicolas, Jacob, Valentine, Mentaverri, Romuald, Kamel, Said, Boullier, Agnès, Slama, Michel“…The virus binds to the angiotensin-converting enzyme 2 (ACE-2) receptor (present on type 2 alveolar cells, bronchial epithelial cells, and endothelial cells), and induces a cytokine storm. …”
Publicado 2022
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490por Li, Delong, Wang, Chong, Wei, Wei, Li, Bo, Liu, Huan, Cheng, Aoming, Niu, Qifang, Han, Zhengxue, Feng, Zhien“…The occurrence of POCs directly led to worse short-term outcomes and poorer long-term overall survival (P=0.0056). Weight loss before the operation (P=0.097), Tumor site (P=0.002), stage T4b (P=0.016), an ACE-27 index of 2-3 (P=0.040), operation time≥8h (P=0.001) and Clindamycin as antibiotic prophylaxis (P=0.001) were significantly associated with POCs. …”
Publicado 2022
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491por Shahbaz, Muhammad Ali, De Bernardi, Francesca, Alatalo, Arto, Sachana, Magdalini, Clerbaux, Laure-Alix, Muñoz, Amalia, Parvatam, Surat, Landesmann, Brigitte, Kanninen, Katja M., Coecke, Sandra“…Loss of the sense of smell (anosmia) has been included as a COVID-19 symptom by the World Health Organization. …”
Publicado 2022
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492por Copcu, Hasim Eray“…The whole world is fighting with the COVID-19 pandemic, which traps people home, causing high business and economic losses, and above all, leads to very serious deaths. …”
Publicado 2020
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493por Ione, Adrienne“…This paper proposes trauma-informed dementia practices consider: 1) intake and assessment to include a screening of ACE score; 2) evaluation of (re)integrating current losses into current developmental and lifespan phase; and 3) offering therapeutic support of current traumatic event (COVID-19) to metabolize past traumatic events in the context of current developmental and lifespan phase.…”
Publicado 2021
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494por Mariam, Solomon H.“…In general, there are few studies on the epidemiology and pathogenesis of the disease in African contexts, and the overall costs and human life losses due to the pandemic in Africa will be determined by all factors and conditions interacting in complex ways.…”
Publicado 2022
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495por Perico, Luca, Morigi, Marina, Pezzotta, Anna, Locatelli, Monica, Imberti, Barbara, Corna, Daniela, Cerullo, Domenico, Benigni, Ariela, Remuzzi, Giuseppe“…Here, we found that S1 injection in mice transgenic for human angiotensin converting enzyme 2 (ACE2) induced early loss of lung endothelial thromboresistance at 3 days, as revealed by thrombomodulin loss and von Willebrand factor (vWF) increase. …”
Publicado 2023
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496“…In individuals with DMD, these processes inevitably cause loss of ambulation shortly after the first decade and an abbreviated life with death in the third or fourth decade due to cardio-respiratory anomalies. …”
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497por Santos, Carlos F., Morandini, Ana C., Dionísio, Thiago J., Faria, Flávio A., Lima, Marta C., Figueiredo, Caio M., Colombini-Ishikiriama, Bella L., Sipert, Carla R., Maciel, Rubens P., Akashi, Ana P., Souza, Gabriela P., Garlet, Gustavo P., Rodini, Camila O., Amaral, Sandra L., Becari, Christiane, Salgado, Maria C., Oliveira, Eduardo B., Matus, Isaac, Didier, Daniela N., Greene, Andrew S.“…When compared to healthy tissue, ACE activity was increased in human gingiva from volunteers with gingivitis. …”
Publicado 2015
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498“…Infection of specific cells which contain the Angiotensin-Converting Enzyme 2 (ACE2) receptor results in a loss of protection of the Mineralocorticoid Receptor (MR). …”
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499“…The relative abundances of Lactobacillus, Terrisporobacter, and Megasphaera in G1 was significantly higher than in the CG (p < 0.05). In the cecum, the ACE index (900.93), Chao1 index (879.10), Simpson index (0.94), and Shannon (5.70) index were higher in G1 than in the remaining groups. …”
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500por Shi, Juan, Zheng, Jian, Tai, Wanbo, Verma, Abhishek K., Zhang, Xiujuan, Geng, Qibin, Wang, Gang, Guan, Xiaoqing, Malisheni, Moffat M., Odle, Abby E., Zhang, Wei, Li, Fang, Perlman, Stanley, Du, Lanying“…In contrast to the prototypic RBD, the mutant RBD completely protected human ACE2 (hACE2)-transgenic mice from lethal challenge with a prototype SARS-CoV-2 strain and a Delta variant without weight loss. …”
Publicado 2022
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